abstracts - how to assess
Download
Report
Transcript abstracts - how to assess
How to assess an
abstract
Objectives
Understand the principle differences
between qualitative and quantitative
research
Understand the basic statistics
employed in research
Be able to assess a piece a research
with confidence!
Qualitative research
Which type of questions does it
answer?
What methodologies are employed?
Improving their validity
Assessing a qualitative paper
Is the qualitative approach
appropriate?
Methodology
Data analysis
Results and conclusion
Quantitative
Types of quantitative research
RCT – design features, advantages &
disadvantages
Cohort Studies
Case control studies
Cross section surveys
BIAS
Selection bias
Observer bias
Participant bias
Withdrawal or drop out bias
Recall bias
Measurement bias
Publication bias
Assessing quantitive research
Commonly used statistics
P values
Relative Risk Reduction
Absolute Risk Reduction
Numbers Need to Treat
Sensitivity
Specificity
Positive Predictive Value
Negative Predictive Value
P values & CI
p value = the probability of the
outcome being due to chance
p = 1 in 20 (0.05).
> 1 in 20 (0.051) = not significant
< 1 in 20 (0.049) = statistically significant
CONFIDENCE INTERVALS
This defines the range of values between which we
could be 95% certain that this result would lie if
this intervention was applied to the general
population
RR, AR, ARR & RRR
What are they?
How do you calculate them?
Warfarin & AF study
The annual rate of stroke was 4.5% for the
control group
Absolute Risk (Control group) = 0.045
1.4% for the warfarin group
Absolute Risk (experimental group) = 0.014
Absolute Risk Reduction = 0.045 – 0.014 =
0.031
NNT = 32
Relative Risk = 0.014/0.045 = 0.31 = 31%
Relative Risk Reduction = 0.045 –
0.014/0.045 = 0.68 = 68%
NNT
How many people you need to treat
with the study intervention to stop
the study event from happening
once.
1/ARR = Number Needed to Treat.
NNT EXAMPLES
Streptokinase + aspririn v.
placebo (ISIS 2)
tPA v. streptokinase
(GUSTO trial)
Simvastatin v. placebo in IHD
(4S study)
Treating hypertension in the
over-60s
Aspirin v. placebo in healthy
adults
prevent 1 death
at 5 weeks
save 1 life with
tPA usage
prevent 1
event in 5y
prevent 1 event
in 5y
prevent MI or
death in 1 year
20
100
15
18
500
Screening tests – assessing
their performance
Sensitivity
The test’s ability to correctly identify those
people with disease.
If Sensitivity is <100% Disease is missed.
So =
True Positives
True Positives + False negatives
i.e. all those who truly Have the disease
Specificity
The test’s ability to correctly exclude those
people without disease
If Specificity <100% then healthy people
are told they may have disease
=
True Negatives
True Negatives + False Positives
i.e. all those who truly don’t have the
disease
Positive predictive value
If the test is positive, what is the
chance of the person having the
disease = positive predictive value.
True Positives
True positives + False Positives
Negative Predictive Value
If the test is negative, what chance
is there that the person doesn’t have
the disease = negative predictive
value.
True negative
True negative + False negative
Accuracy
True positive + True negative
True negative +true positive+ false negative + false positive
Urine dipstick to screen for
Diabetes
Example- urine dip test vs GTT (the gold
standard)
Diabetes +ve
(n=27)
Diabetes –ve
Result of urine test
(n=973)
Glucose present (13)
True +ve 6
False +ve 7
Glucose absent (987)
False –ve 21
True -ve 966