Transcript Creating National and Regional Frameworks to Support HIV

Prevention Research and
National AIDS Plans
20-21 June 2005
Geneva, Switzerland
Prof. Roy Mugerwa
Department of Medicine
Makerere University Medical School
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Aids Plans Geneva
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Synopsis
 Overview
of National AIDS Plans
 Advocacy for Prevention Trials
 Mobilisation/communication
 Co-ordination/Networking/Harmonisation
 Challenges of Prevention Trials
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Why a National AIDS Plan
• A national AIDS plan provides “clear
rules” - Attract partners.
• A well conceived plan could be
presented to development partners
and other international agencies for
collaboration and support.
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National AIDS Plan should:
• Integrate prevention research plans
within the overall National AIDS
Strategy and response.
• Address prevention research within
the context of poverty alleviation
efforts.
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National Plans should outline:
 Legal
framework for the conduct of
biomedical research.
 Regulatory bodies and ethical
approval mechanisms.
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Aids Plans Geneva
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National Plans should emphasize
Advocacy for prevention research
Solicit Political Commitment and Involvement
 Social Mobilization


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Community support and participation
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Information dissem. to the Media and the Public
Involve Policy Makers. Define:
-
Role of National Government Bodies
The role of WHO and UNAIDS
Role of the various partners/stakeholders.
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Advocacy strategies include:Building alliances
 Mobilization of the community
 Communication with policy makers,
scientists, and donors
 Involvement of the media
 Mobilization of resources
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Mobilization of the community
Participation in planning and
implementation of prevention trial
activities.
 Input in the design of the protocol.
 Input into appropriate informed
consent process.
 Information to the community at large
on the proposed research.
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Communication
Educate people about HIV prevention
trials (media, policymakers, civil society,
medical community).
 Engage governments, international
agencies, human and civil rights bodies
in dialogue on prevention trials.
 Encourage women and adolescents
participation but protect the vulnerable
and marginalised.

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Mobilisation of Resources
 Facilitate
communication and
accountability between funders/
stakeholders and scientists.
 Facilitate communication/discussion
between regional and country
HIV/AIDS leaders and WHO/UNAIDS,
AAVP
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Aids Plans Geneva
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Involve the Media
 Advocate
for HIV prevention
research but manage expectations.
 Focus on HIV prevention trials but
not ignore other prevention (TB,
ABC).
 Prevention trials are designed for
and tested in the regions of the
world where they are most needed.
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Co-ordination/Networking
 Create
National and Regional
frameworks to support Prevention
Trials
 Harmonise guidelines across regions.
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Harmonisation of guidelines
across regions:
Promote development of regional
networks to discuss/co-ordinate capacity
building.
 Harmonise training for NRA and ethics
committees: to simplify the review
process.
 Establish Regional Task Forces to develop
guidelines for regulatory review of
vaccines.

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Harmonisation (Cont’d)
• Incorporate general principles and
policies for treatment and care for
intercurrent infections.
• Outline national policies on
treatment of study volunteers who
seroconvert during trials.
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Challenges in Conducting HIV Prevention
Trials in Developing Countries

Inadequate health care outside the
context of research.

Excellent services for trial volunteers with
poor health services in communities.
Improve infrastructures as part of
research agenda.
 Build long term sustainable capacity –
financial, human

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Challenges (Cont’d)
 Less
developed decision making
systems
–
Legal framework; regulatory bodies; IRBs
 Ethical
concerns (consent, vulnerable
populations)
 Cultural and language barriers.
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Challenges (Cont’d)
 Political
suspicions
 Public mistrust/misconceptions
 Media-uninformed/misinformation
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THE ROAD IS RUGGED!
BUT THERE IS A WAY
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Aids Plans Geneva
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