Transcript TREATMENT OF THE DISEASE Master layout or diagram

ERYTHROBLASTOSIS FETALIS
TREATMENT OF THE DISEASE
A potentially life threatening blood disorder in a foetus
or a newborn, arising due to incompatibility with
mother’s blood.
SUPRIYA SARASWATI
INSTRUCTIONS SLIDE
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Master layout or diagram
• Make a schematic diagram of the concept
• Explain the animator about the beginning and ending of
the process.
• Draw image big enough for explaining.
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• In above image, identify and label different components
of the process/phenomenon. (These are like characters
in a film)
• Illustrate the basic flow of action by using arrows. Use
BOLD lines in the diagram, (minimum 2pts.)
• In the slide after that, provide the definitions of ALL the
labels used in the diagram
MASTER LAYOUT
Part Five: TREATMENT OF EF
1. PHOTOTHERAPY
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3.INTRAUTERINE BLOOD TRANSFUSION
2. PLASMAPHERESIS
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Definitions of the components:
1. Phototherapy: Infant is exposed to low levels of UV light to facilitate
breakdown of bilirubin and prevent cerebral damage.
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2. Plasmapheresis: A procedure wherein a machine is used to
separate mother’s blood into two different
fractions- cells and plasma. The plasma containing
the anti Rh antibody is discarded and the cells are
reinfused into the mother using fresh plasma
solution.
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3. Intrauterine blood exchange transfusion: A procedure adopted in
severe cases, to replace fetal Rh+ red blood
cells with Rh- cells, while the fetus is still in
the uterus. In less severe cases, blood
exchange transfusion can wait until after birth.
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Explain the process
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In this step, use an example to explain the concept. It
can be an analogy, a scenario, or an action which
explains this concept/process/topic
Try to use examples from day-to-day life to make it
more clear
You have to describe what steps the animator should
take to make your concept come alive as a series of
moving images.
Keep the examples simple to understand, and also to
illustrate/animate.
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Analogy / Scenario / Action
The immune system of the body is well developed to fight infections and
keep the body healthy. Any foreign substance (antigen) entering the
body makes the immune system produce molecules called antibodies
that destroy the antigen.
Blood transfusions are procedures of transferring blood or blood based
products from one circulatory system into another. For this the blood of
the donor should be compatible with that of the recipient’s blood, which
means the blood types should match. Or else any component not
matching the recipient’s blood type will lead to production of antibodies
in his body against the donor’s blood cells. These antibodies will attack
the newly received blood and kill the blood cells.
Erythroblastosis fetalis is a diseased condition arising from
incompatibility of fetal blood with that of the maternal blood. It usually
happens in Rh- women carrying Rh+ fetus. Maternal antibodies attack
the fetal blood cells and destroy them.
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Stepwise description of process
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The goal of the IDD is to provide instructions to an animator who is
not a expert.
You have to describe what steps the animator should take to make
your concept come alive as a moving visualization.
Use one slide per step. This will ensure clarity of the explanation.
Add a image of the step in the box, and the details in the table
below the box.
You can use any images for reference, but mention about it's
copyright status
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The animator will have to re-draw / re-create the drawings
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Add more slides as per the requirement of the animation
Step 26:
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Action
Description of the action
Audio Narration
Show
•Show baby kept inside a chamber. Breakdown of bilirubin under low
phototherapy
levels of UV light prevents its
•Show UV light falling on baby.
of baby
accumulation and thus cerebral
•Show breakdown of bilirubin
damage. This technique of treatment
molecules.
is called phototherapy.
Step 27:
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Rh- blood
being
transfused to
the fetus
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Action
Description of the action
Audio Narration
Intrauterine blood exchange transfusion
•Show blood being injected into the
Show
is done only severe cases. Is employed
intrauterine fetus to replace Rh+ blood by Rhto replace fetal Rh+ blood with Rhblood.
blood
blood. In less severe cases, blood
transfusion •Show Rh- blood entering fetus.
exchange transfusion can wait until
of baby
after birth.
Step 28:
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Action
Show
plasmapheresis
Description of the action
•Show Rh- woman.
•Show blood being drawn from her
from an injection and emptied into a
test tube.
•Show another tube with different
components of blood separated by a
separating machine.
Audio Narration
Plasmapheresis is employed as a
treatment method and is performed
on the mother.
Step 29:
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mixed
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Fresh Plasma
Action
Show
plasmapheresis
Description of the action
Audio Narration
•Show some antibodies in the plasma Plasma containing the antibodies
against Rh antigen is discarded and
fraction.
the cells are mixed with fresh
•Show that plasma is discarded. The
plasma solution and reinfused into
cell fraction is mixed with fresh
the mother.
plasma from another tube.
•Show this is reinfused into the
mother.
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Animation design
• Please see the design template provided in
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the next slide.
• This is a sample template, and you are free
3 to change as per your design
requirements.
• Try and recreate the sections/subsections
as shown in the template.
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Interactivity and Boundary limits
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In this section, you will add the ‘Interactivity’ options to the
animation.
Use the template in the next slide to give the details.
Insert the image of the step/s (explained earlier in the
Section 3) in the box, and provide the details in the table
below.
The details of Interactivity could be:
 Types: Drop down, Slider bar, Data inputs etc.
 Options: Select one, Multiple selections etc
 Boundary Limits: Values of the parameters, which won’t
show results after a particular point
 Results: Explain the effect of the interaction in this column
Add more slides if necessary
Interactivity option 1:Step No:
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Which is the correct sequence of events occurring in erythroblastosis
fetalis?
A. Rh+ fetal RBCs enter maternal circulation
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B. Production of antibodies against fetal RBCs
in the mother’s body
C. Release of immature erythrocytes from the fetal
bone marrow
D. Differentiation of B cells into plasma cells and
memory B cells
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Interacativity Type
Constructing
the correct
sequence
Options
Select and drag event
boxes in the correct
manner in the empty
boxes given below.
Incorrect sequence
should make the box turn
red. Correct sequence
boxes should turn green.
Boundary/limits
Results
Correct sequence
is: A D B C
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Interactivity option 2:Step No:
A cell separating machine is used to separate mother’s blood into cell and
plasma fraction, after which antibody containing plasma fraction is discarded
and cells are reinfused into the mother on mixing with a fresh plasma
solution. Which technique is this?
A. Phototherapy
B. Intrauterine blood transfusion
C. Plasmapheresis
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Interacativity Type
Matching the
correct option
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Options
Boundary/limits
Select and drag the correct
technique that describes it
the best. Technique box
should be selected and
dragged into the empty boxes
shown. Correct box should
turn green and incorrect
boxes should turn red.
Results
The correct
option is C
Links for further reading
Reference websites:
www.nlm.nih.gov
http://en.wikipedia.org
www.marchofdimes.com
www.mercksource.com
Books:
Textbook of Immunology, Kuby
Textbook of Medical Physiology, Guyton
Research papers: