Transcript Allergies, Inflammation, and Fibromyalgia - Meta

ALLERGY:
is a disorder of the immune system.
It is characterized by excessive activation of certain
white blood cells called mast cells and basophils by a
type of antibody known as IgE, resulting in an
extreme
INFLAMMATORY response.
Immune System Health and Low Cortisol
Just as a high cortisol suppresses the immune system, a low
cortisol can result in unbridled immune system action. The
immune defenses become overly aggressive and not only attack
invading organisms, but mount allergic reactions against many
environmental agents. "Allergic reactions" can also be directed
against endogenous antigens, the components of our own bodies.
Autoimmune conditions such as lupus, Rheumatoid arthritis and
Sjogrens syndrome can activate during periods when cortisol
levels are low.
Pauline N. Harding, MD
GLUTEN GRAIN INTOLERANCE AND STRESS
In many individuals, the gut becomes inflamed within 30 minutes
after consuming gluten-containing grains such as wheat, oats, rye,
barley, and spelt. This inflammatory response in the
intestinal tract is tantamount to having a "30-footlong sore throat." In infants we call it colic. We
assume the child "outgrows" the food allergy. In fact, the body
merely learns to respond to this inflammation by secreting cortisol
and, in many cases, an endogenous morphine-like substance to
"cover up" the pain and suppress the inflammation. This narcotic
substance absorbs into the bloodstream and travels to the brain
where it stimulates morphine receptors, and the individual becomes
physiologically addicted to the grain or dairy product that induced
the inflammation. Observe the symptoms and behavior patterns of
individuals consuming grain and dairy products, and note the
striking similarities with the "upper" and "downer" phases of drug
intake and withdrawal. The similarities with drug addiction become
even more striking when the individuals attempt to stop eating dairy
and grain products.
Pauline N. Harding, MD
THE ASSOCIATION OF…
IRRITABLE BOWEL SYNDROME AND FIBROMYALGIA
Irritable bowel syndrome (IBS) is a very common gastrointestinal condition, which
is present in 8-20% of the general population. Several population-based studies
have demonstrated IBS symptoms to be more common in women, with
prevalence ratios ranging from 2 to 3:1. It has been estimated to affect 14-24% of
women and 5-19% of men. The classic gastrointestinal symptoms of IBS are
chronic or recurrent abdominal pain and/or discomfort and associated alterations
in bowel habits. However, many individuals with IBS also suffer from
nongastrointestinal symptoms. Rheumatologic symptoms, such as skin rashes,
muscle contraction headache and myalgias, have been reported in two-thirds of
IBS patients. Previous studies have found that IBS typically overlaps with
fibromyalgia syndrome (FM) in the same patient, suggesting a common cause.
FM occurs in up to 60% of patients with irritable bowel
FM occurs in up to 60% of
patients with IRRITABLE
BOWEL
Lin Chang, MD
Associate Professor of Medicine,
Co-Director of the UCLA/CURE Neuroenteric Disease Program,
Director of the UCLA Motility Unit
FIBROMYALGIA SYMPTOM COMPLEX
• Tenderness of specific anatomical sites (at least 11 of
18 points)
• Chronic aching
• Stiffness
• Sleep disturbances
• Pain
• Headaches
• Anxiety
• Depression
• Chronic fatigue
• Intestinal disturbances
• Subjective soft tissue swelling
• Cardiovascular problems (dizziness, palpitations)
• Type II muscle fiber atropy
• Mitochondrial abnormalities
• Low Levels of ATP
Because FM is a multifactorial condition of questionable etiology,
treatment that addresses the various bodily systems or processes
known to be defective may be of benefit. While medications
prescribed for FM complaints may provide temporary relief,
they
may not address the underlying factors involved and can
cause
undesirable side effects such as headache, nausea,
drowsiness, or
constipation.
ON
THE OTHER HAND, NUTRITION AND DIETARY SUPPLEMENTS
THAT SUPPORT THE NERVOUS, ENDOCRINE, AND DIGESTIVE
National Institute
of Arthritis and Musculoskeletal Skin Diseases. National Institutes of Health. Fibromyalgia.
SYSTEMS
AND
FACILITATE THE REMOVAL OF TOXINS MAY
Retreived July 2, 2002 from, http://www.niams.nih.gov/hi/topics/fibromyalgia/fibrofs.htm
2. Arthritis Foundation
Disease Center.
Fibromyalgia.
RetrievedPROCESS.
July 22, 2002 from,
ASSIST
THE BODY
IN THE
HEALING
http://www.arthritis.org/conditions/DiseaseCenter/fibromyalgia.asp
3. Rooks DS, Silverman CB, Kantrowitz FG. The effects of progressive strength training and aerobic exercise on
muscle strength and cardiovascular fitness in women with fibromyalgia: a pilot study. Arthritis Rheum
2002;47(1):22-28.
4. Jones KD, Burckhardt CS, Clark SR, et al. A randomized controlled trial of muscle strengthening versus
flexibility
training in fibromyalgia. J Rheumatol 2002;29:1041-48.
5. Thorson K. Fibromyalgia syndrome (FMS) political case statement. Retrieved March 6, 2002 from,
http://www.fmnetnews.com/pages/case.html
6. Smythe HA. “Fibrositis” and Other Diffuse Musculoskeletal Syndromes. In: Kelley WN, et al., eds. Textbook
of Rheumatology. 1st ed. Philadelphia: WB Saunders; 1985:481-89.
CYTOKINE (INFLAMMATION like signaling hormone) A CAUSE OF:
FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME
“cytokines regulate the immune system responses and can drive the
inflammatory process.” Dr. Lionel Ivashkiv
It is thought that highly elevated cytokine levels found in the brains of
Alzheimer's patients contribute to their symptoms. Abnormal cytokine
activity in rheumatoid arthritis leads to damaged joints. Cytokine
disturbances have been implicated, but not always well understood, in
other autoimmune disorders as well.
According to the latest statistics, new cases of diabetes have
increased by 90 percent in the last 10 years, and diabetes or prediabetes now strikes one in four Americans. Those are absolutely
astounding statistics to say the least.
There’s no doubt in my mind that one of the primary fuels for this
epidemic is the excess consumption of high fructose corn syrup
(HFCS). Several studies over the past few years have also come to
this conclusion, including this latest study in Cell Metabolism, in
which the researchers note:
“Insulin resistance is a common feature of the metabolic syndrome
and type 2 diabetes mellitus (T2DM). Both have reached epidemic
proportions worldwide with the global adoption of the westernized
diet along with increased consumption of fructose, stemming from
the wide and increasing use of high-fructose corn syrup
sweeteners.
IT IS
WELL ESTABLISHED
THAT
FRUCTOSE
IS MORE LIPOGENIC
Nonalcoholic
Fatty
Liver
- Nonalcoholic
Steatohepatitis
THAN GLUCOSE, AND HIGH-FRUCTOSE DIETS HAVE BEEN LINKED
Adiponectin hormone plays a role in the suppression of the metabolic derangements that may result in type 2 diabetes,[4] obesity,
[3] non-alcoholic fatty liver disease
TO
HYPERTRIGLYCERIDEMIA,
NONALCOHOLIC
FATTYrisk
LIVER
atherosclerosis,
(NAFLD) and an independant
factor for metabolic syndrome.[5]
DISEASE (NAFLD), AND INSULIN RESISTANCE.”
Balancing
Essential Fats in
Foods
3
6
Promotes Health
and
Prevents Disease
A Balanced Response is Needed
Vitamin-like
essential fats
===========>>>
metabolized to
FOOD > short 3
===>> long 3 =======>>
FOOD > metabolized to
metabolized to
FOOD > short 6
===>> long 6 =======>>
Hormone-like
eicosanoids
3-eicos ===>>
moderate responses
6-eicos ===>> vigorous responses
3-eicos make responses
long 3 makes 3-eicos
Short 3
makes long 3
.
A Balanced Response is Needed
Vitamin-like
essential fats
===========>>>
metabolized to
FOOD > short 3
===>> long 3 =======>>
FOOD > metabolized to
metabolized to
FOOD > short 6
===>> long 6 =======>>
Hormone-like
eicosanoids
3-eicos ===>>
moderate responses
6-eicos ===>> vigorous responses
6-eicos make responses
long 6 makes 6-eicos
Short 6
makes long 6
Eicosanoids Differ
Anything 3 can do
I can do better!
3
6
Good grief!
Sometimes
6
is just too much!
Eicosanoids Differ
Anything 3 can do
I can do better!
3
6
Good grief!
Sometimes
6
is just too much!
A Balanced Response is Needed
Vitamin-like
essential fats
===========>>>
metabolized to
FOOD > short 3
===>> long 3 =======>>
FOOD > metabolized to
metabolized to
FOOD > short 6
===>> long 6 =======>>
Hormone-like
eicosanoids
3-eicos ===>>
6-eicos ===>> vigorous responses
Make balanced food choices !
Excessive 6-eicos occur in:
Conditions for which you take
aspirin, ibuprofen(Motrin),
acetominophen(Tylenol),
COX-2 blockers, & NSAID’s
all have excessive 6-eicosanoids
moderate responses
Heart attacks
Strokes
Thrombosis
Arrhythmia
Arthritis
Asthma
Menstrual cramps
Headaches
Tumor metastases
NUTRITION helps in
PREVENTION of
what gets TREATMENT
with DRUGS
A Balanced Response is Needed
Vitamin-like
essential fats
===========>>>
metabolized to
Hormone-like
eicosanoids
FOOD > short 3
===>> long 3 =======>> 3-eicos
FOOD > metabolized to
metabolized to
FOOD > short 6
===>> long 6
=======>> 6-eicos
===>>
moderate responses
===>> vigorous responses
Make balanced food choices !
Excessive 6-eicos occur in:
Balance the 6's and the 3's
in your body
% long 6 in long total ==>>>
Heart attack deaths/100,000 ===>>>
Heart attacks
Strokes
Thrombosis
Arrhythmia
Arthritis
Asthma
Menstrual cramps
Headaches
Tumor metastases
47%
58%
78%
Japan
Medit.
USA
50
90
200
.
Your food choices make
the % long 6 in your body
% long 6 in long total ==>>>
Heart attack deaths/100,000 ===>>>
47%
58%
78%
Japan
Medit.
USA
50
90
200
Linoleic and linolenic acids (en%)
Based on foods available for consumption in the U.S.(1909-1999)
Energy % /d/person
8
7
6
linoleic, 18:2n-6
5
4
3
2
linolenic, 18:3n-3
1
0
1900
1920
1940
Year
1960
1980
2000
One interesting question is whether the change in linoleic acid over the last 100 years
correlates with changes in the prevalence rates of major depression in the same time period
The next slide describes the correlations between changing cumulative rates of major depression
at each age estimated from the ECA data and the linolenic acid (en%) available for consumption
in the food supply.
Increases in cumulative rates of major depression during the 20 th century
and increased linoleic acid (en%) in the U.S. food supply.
Cumulative rates of depression
0.10
Age 35
r = 0.999
F= 268
p<0.00001
Age 45
r = 0.994
F= 286
p<0.0007
0.08
0.06
1985
0.04
Age 25
r = 0.978
F= 89
p<0.0007
1975
0.02
1965
1945 1955
1925 1935
0.00
-0.02
2
3
4
5
6
7
8
Linoleic acid, energy % of all foods available for consumption
Hibbeln et al 2002, unpublished
A great approach to address a
number of patient concerns
Fully-reacted magnesium glycinate enables therapeutic levels
of oral magnesium supplementation without gastrointestinal
upset or diarrhea7
• Dosage levels 300 - 600 mg
– Fibromyalgia1
- Chronic fatigue2
– Migraine3
- Muscle spasm4
– Tension headache5
- Persistent muscle pain6
1. Abraham GE, Flechas JD. Nutr Med1992;3:4959
2. Durlach J. Magnes Res1992;5(1):68
3. Peikert A, Wilimzig C, Kohne-Volland R.. Cephalalgia. 1996 Jun;16(4):257-63
4. Webb WL, Gehi M. Psychosomatics 1981;22:1991-1203
5. Altura BM, Altura BT. Med Hypotheses. 2001 Dec;57(6):705-13
6. Bilbey DL, Prabhakaran VM. Can Fam Physician. 1996 Jul;42:1348-51
7. Schuette SA, et al. JPEN J Parenter Enteral Nutr 1994 Sep-Oct;18(5):430-5
CONSIDERATIONS:
Calm systemic inflammatory status
Support antioxidant pathways
Address fatty acid profile
Assess status of hsCRP and other inflammatory
markers
Assess general physical symptoms with MSQ
NUTRITIONAL SUPPORT:
Medical food for inflammation
Anti-inflammatory diet program
RIAA and vitamin D nutraceutical
Omega-3 (high EPA) supplement