Transcript 第五章 细胞因子

Section 6
cytokines
Chapter 1
introduction
CYTOKINE (CK)
 Many
critical interactions among
cells of IS are controlled by
soluble mediators (CK)
A
diverse group of intercellular
signaling peptide and
glycoproteins with small MW
 Several
hundred have been identified
to date
 The
source of CK
– Immune cells
– Other non-immune cells
– some tumor cells

Be secreted by particular cell
types in response to a variety of
stimuli
 Produces
characteristic effects on
the growth , mobility,
differentiation, or function of
target cells
 Multiple
functions
 regulate immune and inflammatory
responses
 healing, hematopoiesis,
angiogenesis, et al
 Potent
compounds with low
concentration
 By
binding to specific surface
receptors on target cells
 Produced
locally by a variety of
tissues and cells
 Most
CK act in paracrine or
autocrine manner
 Only
a few CK act in endocrine
manner
Classification

lymphokines: the CK produced
by lymphocytes

monokines: the CK produced by
monocytes or macrophages
Complexity of effects
may be secreted individually or
coordinated response along with
other, unrelated cytokines
 Overlap extensively
 Antagonistic

Overlap
coordinated
Antagonistic
Chapter 2
classification and
biological activities of
CK
classification

interleukins
 tumor necrosis factor
 interferon
 hematopoietic colony stimulationg
factors
 transforming growth factor
 chemokines
Interleukins (IL)
 Been
assigned a number
 Mainly produced by leukocyte
 Some are produced by other cell
populations
IL-2

An autocrine and paracrine
growth factor secreted by
activated T cell

has very short half-life in the
circulation , mainly autocrine
and paracrine
IL-2

critical for activating all types of
acquired immune responses
 Be
essential for clonal T cell
proliferation
IL-2
 apoptosis
of T cell after
prolonged or repeated activation
 Two-edged
sword that initiates
IR but also limits their intensity
and duration
tumor necrosis factor, TNF
• TNF-αand TNF-β
• Induce hemorrhagic necrosis of
certain tumors
• Wasting syndrome (cachexia)
• Take part in IR
interferon, IFN

IFN-/ (typeⅠ)
and IFN- (typeⅡ )
antivirus
typeⅠ
anti-tumor
immune regulation---- typeⅡ
colony stimulating factor, CSF

support the production of particular mature
blood cell types from pluripotent stem cells
or committed progenitors in the bone
marrow

Granulocyte-CSF, G-CSF
monocyte-CSF, m-CSF
erythropoietin, EPO
Transforming growth factor, (GF）
 As
a growth factor for fibroblasts
that promoted wound healing
 As
a negative regulator of immunity
and hematopoiesis
chemokines
 Chemoattractant
activity for
monocytes and neutrophiles
 Multifunctional
 Have little or no effect on cell
proliferation
chemotaxis