Transcript Unit 4 Seminar Cellular immunity Immunology Dr. Furr A quick

Unit 4 Seminar
Cellular immunity
Immunology
Dr. Furr
A quick review……
• How is cellular immunity (T cell) different than
humoral (B cell) immunity?
• B cells- produce antibodies
• Killer T cells (CTLs)- release chemicals to destroy
infected cells, cancer cells
T cell activation
• CTLs and T helper cells are activated in a similar
way:
• 2 signals needed to activate naïve cells:
1. Antigen recognition on MHC II of antigen
presenting cell
2. Co-stimulatory signal from same cell
Differentiate between: killer T cells, Th1 cells, Th2
cells, Th17 cells, and T0 cells.
• Killer T cells-CD8+
-Recognize antigen on MHC I
• Th1 cells- Bacterial or viral infection in the tissues
- Release cytokines to charge macrophages and NK
• Th2 cells-Parasites and bacterial infections
Differentiate between: killer T cells, Th1 cells, Th2
cells, Th17 cells, and T0 cells.
• Th17 cells-fungal infections, some bacteria
- Triggers neutrophil activation
• T0 cells-uncommitted until they reach the site of infection
- Differentiate into Th1 cells, Th2 cells, or Th17 cells
* Why are these cells important??
Consider the following case studies and
interpret the results. What kind of infection
does the patient most likely have? How
can you tell?
Case A- Elevated killer T
cell levels, elevated Th1 cell
levels
• Case A- Elevated killer T cell levels, elevated Th1 cell
levels
• Viral or bacterial infection in the tissues
What does the high CTL count mean??
Case B- Elevated B cell
levels, elevated Th2 cell
levels
• Case B- Elevated B cell levels, elevated Th2 cell
levels
-parasites or intestinal bacterial infection
- Th2 cells secrete cytokines that charge NK and MO
cells
Case C- Elevated Th17 cell
levels, elevated
macrophage and neutrophil
levels
• Case C- Elevated Th17 cell levels, elevated
macrophage and neutrophil levels
• Most likely a fungal infection
• Release of IL-17 triggers MO and neutrophil
activation
Unit 4 assignment
• Researching the Immune System
• In this research writing assignment you will be
composing an essay in which you provide a 7001,000 word response to the specific questions
below. You should include a well developed
introduction and conclusion. Be sure to answer all
parts of each question in full and complete
sentences and support your answers with research.
You should consult at least three references
including your textbook.
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Assignment questions:
Compare and contrast the major roles of the innate immune system and
the acquired immune system.
How do the innate immune system and the acquired immune system
work together to fight infectious agents?
Basic Writing Expectations
Your report should be at least 700-1,000 words, not counting the title or
reference pp.
Include a separate title page and reference page.
Double space, font size 10 to 12 pt.
Include a highly developed viewpoint/thesis, purpose and exceptional
content.
Demonstrate superior organization: use logic.
Make certain that your paper is free of grammatical and spelling errors.
Avoid plagiarism.
Use APA style for all in-text citations and references.
Always include an introduction and conclusion.