Transcript No Slide Title

IL-18 Production and Role in Immune Response
SIGMA-ALDRICH
IL-18 Production and Role in Immune Response
IL-18 mRNA has been detected in keratinocytes, small intestine epithelial cells, adrenal
cells, macrophages, pancrease, skeletal muscle, liver, lung and PBMC (peripheral blood
mononuclear cells). IL-18 receptors have been identified only on T, B and NK cells. The
primary immune actions of IL-18 appear to be through the induction of high levels of IFN-g
production.