Transcript Celularni imunski odgovor Aktivacija T limfocita

Cell-mediated
immune response
Activation of T lymphocytes by
intracellular microorganisms
Phases of T cell response
Biochemical pathways of T cell activation
Functional responses of T lymphocytes to antigens and
costimulation
Molecules involved in T cell activation
TCR
TCR complex
Costimulators
Requirement for two signals in T
cell activation
Molecules involved in T cell activation
Coreceptor
Adhesion
molecule
Molecules involved in T cell activation
Accessory molecules
Molecules involved in T cell activation
Immunological synapse
Biochemical pathways of
T cell activation
Clustering of
two or more
TCRs
Functional responses of
T lymphocytes to antigens
and costimulation
Clonal expansion of T-limphocytes
Diferentiation od CD4+ T-limphocytes
IFN-g
IL-12+IL-18
IL-4
Th1
Th2
Naivna
Naïve
CD4++T
TGF-b+IL-6
IL-23…
TGF-b
Th17
Treg
Diferentiation od CD4+ T-limphocytes
IFN-g
IL-12+IL-18
IL-4
Th1
T-bet
Th2
GATA-3
Naivna
Naïve
CD4++T
TGF-b+IL-6
IL-23…
TGF-b
Th17
RORgt
Treg
FoxP3
Diferentiation of naive
CD4+ T-cells
Diferentiation od CD8+ T-limphocytes
1. Recognition of antigen by T cells is mediated by
a. IL-2
2. Signal transduction in T cells is mediated by
b. stabilize binding of T-cells
to APC
c. a and b chains of TCR
3. Accesory molecules involved in T cell activation
are
d. two signals
4. Costimulatory signals for T cell activation are
provided by
e. NFAT, NF-kB and AP1
5. T cell growth factor is
f.
CD28 and B7 molecules
6. If APC does not express costimulatory
molecules
7. Adhesion molecules
g. CD3, CD4, CD8, CD28 and
adhesion molecules
8. Activation of naive T-cells requires
h. IL-12
9. Cytokine that is crucial for TH1 differentiation is
i.
T cell is not activated
10. Main transcription factors in T cell activation are
j.
CD3 complex and z chains
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c
2.____
j
3.____
g
4.____
f
5.____
a
6.____
i
7.____
b
8.____
d
9.____
h
10.____
e