Transcript Immunology Stack - U

Immunology Stack
Slackers Facts by Mike Ori
Disclaimer
The information represents my understanding only so errors and omissions are
probably rampant. It has not been vetted or reviewed by faculty. The source is our
class notes.
The document can mostly be used forward and backward. I tried to mark
questionable stuff with (?).
If you want it to look pretty, steal some crayons and go to town.
Finally…
If you’re a gunner, buck up and do your own work.
SLE antibodies
Anti-phospholipid
Anti-smith
Anti-dsDNA
SLE mortality factors
Short term: active disease (renal) and infection
Long term: chronic renal failure, heart failure,
malignancies, infection
SLE treatment
Immune suppression with cyclophosphamide
and corticosteroids
Rheumatoid arthritis antibodies
RF
What is Rheumatoid Factor?
IgM antibodies directed against an
immunoglobin such as IgG
RA description
Autoimmune attack on synovium leads to
synovial overgrowth (fronding) onto articular
cartilage causing irreversible joint destruction
and malformation.
Other RA affected areas
Nodules in soft tissue, inflammation of the eye,
vasculitis.
RA Immune cell involvement
CD4+ T and B cell infiltrates into joins with
lymphoid follicle formation
Sjogren syndrome antibodies
Anti-SS-A/Ro
Anti-SS-B/La
Sjogren description
Autoimmune destruction of exocrine gland
epithelium particularly that of the salivary and
lacrimal glands. Formation of germinal
centers is possible.
Sjogren cells
CD4+ cells.
NOTE: Although ab are present, they do not
appear to be the principle cause of the
damage. (Robbins)
Sjogren’s linked disease
40x increased risk of B cell lymphoma
Scleroderma Ab
Anti-scl 70
Anti-nucleolar
Systemic sclerosis (Sceroderma) description
Progressive fibrosis located throughout the body
particularly the skin and to a lesser extent the
GI tract, kidneys, heart, muscles, and lungs.
Scleroderma cells
CD4+ T cells activate fibroblasts through
unknown mechanisms.
Systemic Vasculitis Antibodies
Anti-neutrophil cytoplasmic antigen (ANCA)
Systemic vasculitis description
Immune response that results in either the
deposition of Ab/Ag complexes or the binding
of Ab in situ to elements of the endothelium.
This results in a range of diseases involving the
vasculature including wegener granulomatosis
and churg-strauss. The reaction may range
from mild to fatal.
Systemic vasculitis causes
Drugs and viruses