Transcript Slide 1

Development of an Animal Model for Robotic Stroke
Therapy
Nicole Bogdanovich, RET Fellow 2009
Foreman High School
RET Mentor: Dr. Patrick Rousche, PhD
NSF- RET Program
Behavior Training
Introduction
Motivation
cerebral artery
The overall goal of this project is to gain a better
understanding of brain tissue reorganization following
stroke using electrophysiological recordings to help in
developing stroke therapies and optimize recovery in
the future.
Background
Two sets of six are trained using the basic principles of
operant conditioning.
Step 1-The rats are first familiarized with the training box
and robot. When they recognize the robot they are
rewarded with food pellets.
Hypothesis
Step 2-Once the rats are familiarized the rats are trained
to touch their right paw to the robot handle. The rats are
food restricted in order for them to have motivation to be
trained.
•Stroke is the leading cause of severe disability in
the United States and often leads to permanent
neurological deficits.
•About 795,000 people suffer a a stroke annually. This
causes an approximate economic burden of $68.9
billion.
•87% of strokes are ischemic
Step 3 –The rats will be trained to move the robot handle
with their right paw.
Motor Function Assay
Results
Week 23-Right Paw Usage 1st 10 Mins
Week 22-W,Th,F Right Paw Usage 2nd 10 Mins
60
60
2
40
3
4
20
5
6
0
0
0.5
1
1.5
2
2.5
3
3.5
Number of Times
Used Right Paw
# of 3 Pellet
Rewards
80
50
Rat 2
40
Rat 3
30
Rat 4
20
Rat 5
10
Rat 6
0
-20
Day
Day
References
[1] American Heart Association 2008 Heart Disease and Stroke
Statistics—2008 Update
Teaching Module
Plan
[4] T.C. Chiganos,W. Jensen, P.J. Rousche: J. Neural Eng. 3, 2006, L15–L22.
[5] R.P. Allred, T.A. Jones: Experimental Neurology 210, 2008, 172–181.
[6] R. P. Allred, D.L. Adkins: J. Neuroscience Methods 170, 2008, 229–244.
[7] W. Jensen, P. J. Rousche, “Encoding of Self‐Paced, Repetitive Forelimb
Movements in Rat Primary Motor Cortex,” IEEE 2004.
 NSF EEC-0743068 Grant
 Prof. A. Linninger, RET Program Director
[2] www.stroke.org
[3] W. Jensen, P.J. Rousche, T.C. Chiganos, “A method for monitoring intracortical
motor cortex responses in an animal model of ischemic stroke,” IEEE EMBS Annual
International Conference New York City, USA, Aug 30‐ Sept 3, 2006.
Acknowledgements
Chicago Science Art Competition 2009
 Dr. Gerardo Ruiz, RET Program Managing Director
 Dr. Patrick Rousche, Research Mentor
 Everyone at the Neural Engineering and Applications
Laboratory
 University of Illinois- Chicago