Dermatology Board Review
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Transcript Dermatology Board Review
Infantile Hemangiomas
Most common vascular tumor of
infancy
10%
More common in
Caucasians
Females
Premature infants
Placental abnormalities
Location
>50% head and neck
25% trunk
Rest on extremities
Timing
Several days to weeks after
delivery
Infantile Hemangiomas
Description
Reddening or bluish
discoloration of skin
Bright red nodule or plaque with
elevation
Types
Superficial (epidermal)
“Strawberry” or bright red
Well demarcated
Elevated
Soft compressible
Few mm to 5cm
Deep (dermis or subq fat)
Bluish hue
Indistinct borders
Doughy consistency
Enlarge when dependent
Mixed
Most hemangiomas
Infantile Hemangiomas
Course
Grow and peak by 6-9
months
Stabilization
Involution
10% per year
Graying out of surface
40% with residual skin
changes
Telangiectasias
Fibro-fatty tissue
Hemangiomatosis
Multiple hemangiomas
Benign
Limited to the skin
Not benign
Numerous small (<2cm), widely
dispersed cutaneous lesions
Internal or visceral lesions
Liver
May have AV shunts and precipitate highoutput CHF
6-12 weeks of age
GI tract
Bleeding
CNS
Mass effect
Lungs
When to worry?
Lower face
Lower lip, chin,
preauricular, neck
“beard” distribution
Airway involvement
Midline lumbosacral
Spinal dysraphism
PHACES syndrome
Posterior fossa malformations
Hemangiomas
Plaque-like segmental
hemangioma of the face
May initially be confused with
port-wine stain
Often ulcerate and proliferate
rapidly
Arterial anomalies
Carotid
Cardiac defects
Eye anomalies
Sternal clefting
Complications
Periorbital and lid lesions
Occlusion of the visual axis
Corneal compression
Must be treated
aggressively
Amblyopia, strabismus,
astigmatism
Lips, nose or ears
High potential for
disfigurement
High friction areas
Ulceration
Secondary infection
Scarring
Treatment
Conservative management for most
Lesions involving the airway or the eye
Steroids
Interferon
Surgical intervention
Common benign vascular tumors
Overgrowth of granulation tissue
Following minor trauma
Foreign body
Timing
Well after the newborn period
Location
Usually face or extremity
Description
Solitary bright red, soft nodules
Pedunculated
5-6mm
Friable surface
Treatment
Excision
Electrodessication of the “feeder” vessels
May recur
Nevus Simplex
AKA Salmon Patch or “Stork Bite”
Capillary malformation
Seen in majority of infants at birth
Location
Nape of neck
Glabella
Forehead
Upper eyelids
Lower back
Course
Fade with time
More apparent when crying or straining
Nevus Flammeus
AKA Port-Wine stain
Congenital capillary/venous
malformation
Description
Purple-red
Location
Unilaterally on face
Course
Do not enlarge or involute
Sturge-Weber Syndrome
Port wine stain
Distribution of the trigeminal nerve
Vascular malformations of the
ipsilateral leptomeninges and
cerebral cortex
Glaucoma
Other
Seizures, MR, hemiplegia
Klippel-Trenaunay Syndrome
Port wine stain
Over an extremity
Hemihypertrophy
Soft tissue and bony overgrowth
A new adolescent patient is seen in your office for a sports
physical. He points out a hairless, well-circumscribed,
yellowish waxy plaque located on his scalp. He says its
been there since birth but has recently become more
raised. He wants to know what it is?
A. Epidermal nevi
B. Congenital
nevomelanocytic nevi
C. Halo nevus
D. Nevus sebaceous
E. Ash-leaf spot
Congenital Nevomelanocytic
Nevi
Description
Pigmented plaques often
associated with dense hair
growth
Course
Birth
Tan or light pink with soft vellus
hairs
Infancy and childhood
Darkening with small dark
macules or nodules within the
plaque and prominent hair
Congenital Nevomelanocytic
Nevi
Size
Small <1.5cm
Medium 1.5-20cm
Large or Giant >20cm
Prognosis
All have potential for malignant
transformation
New, darker and/or bleeding
nodules
Sudden growth
1-4% small to medium
10-30% Giant
Congenital Nevomelanocytic Nevi
Management
Small to medium
Yearly follow-up with derm
Excision if atypical or difficult to monitor
Giant
Early, full thickness excision followed by grafting
OR
Close observation every 6 months
Acquired Nevomelanocytic Nevi
Timing
Early childhood
Description
Small, flat, pigmented macules
1-2mm
Location
Sun-exposed areas
Course
Junctional nevi
Limited to epidermal-dermal junction
Compound nevi
Papular or pedunculated
Proliferation into the dermis
Change slowly over months and only
warrant observation
Acquired Nevomelanocytic
Nevi
Halo nevus
Hypopigmented or
depigmented ring associated
with mild local pruritus around
a benign nevus
Caused by cytotoxic Tlymphocyte reaction
Course
Eventual resolution and nevus
disappears
Childhood
De novo
Within giant congenital nevus or
other nevus
Transplacental transfer
Red Flags
Change in size, shape or outline
Scalloped, irregular borders
Change in surface characteristics
Small, dark, elevated papule or
nodule within a flat plaque
Flaking, scaling, ulceration or
bleeding
Change in color
Different shade or to a mixture of red,
white or blue
Development of burning, itching or
tenderness
Blue nevus
Small, firm, blue papule
Deep nevus cells
Traumatic hemorrhage
Under the nails or in mucous
membranes
Vascular lesions
Pyogenic granuloma or
angiokeratoma
Spitz nevus
Red and rapidly growing nevus
Composed of spindle and
epithelial cells
Confused histologically with
melanoma
Epidermal Nevi
Epidermal structures only
Timing
Birth or childhood
Description
Slightly hyperpigmented
papillomatous or verrucous growth
Increases in verrucous changes are
common at puberty
Small and localized, linear,
dermatomal or generalized
Other associations if extensive
Seizures, MR, ocular and skeletal
defects, hypophosphatemic
vitamin D-resistant rickets
Nevus sebaceous of Jadassohn
Epidermal proliferation, abortive hair
follicles, sebaceous glands and apocrine
structures
Timing
Present at birth
More verrucous, raised and nodular at
puberty
Description
Hairless, well-circumscribed, skin-colored
or yellowish waxy plaque
Linear or round
Location
Scalp, face or neck
Course
Routine excision not recommended in
childhood
Malignancy risk is low
May excise in adolescence or adulthood