Transcript IOIS COTS presentation

Welcome
To the future of Ocular TB, To the future of collaboration
COTS: Brief
• International encrypted cloud-based registry for Ocular Tuberculosis
• 1st international registry for Ocular Tuberculosis
• 1st attempt to use an encrypted cloud-based platform for medical study
Why Ocular TB
• TB estimated prevalence of 1/3 of the Worlds population
• Reports of Ocular involvement in 1-2% of all patients with Systemic TB
• Presentations are diverse without accepted diagnostic criteria
• Lack of practical and reliable diagnostic tests
Aims
• Collect good quality data to support reproducible recommendations
• Clarify clinical evaluation and management of Ocular TB
Methods - Team
ID
Site Name
ID
Site Name
ID
Site Name
001
Advanced Eye Centre, PGIMER
010 Shroff Eye Centre, India
019 University of Istanbul, Turkey
002
Moorfields Eye Hospital, London
011 University of Manchester, UK
020 University of Thessaloniki, Greece
003
Tan Tock Seng Hospital, Singapore
012 University of Monstair, Turkey
021 Northwestern University, Chicago
004
Singapore National Eye Centre
013 La Source Eye Centre, Laussane
022 LVPEI Bhubaneswar, India
005
Aravind Eye Care, India
014 Save Sight Institute, Sydney
023 Marche-Ancona University , Italy
006
Narayana Nethrayala, India
015 King Khaled Eye Hospital, Riyadh
007
LV Prasad Eye Institute, India
016 Luigi Hospital Milan, Italy
024 Dr Shroff’s Charity Eye Hospital,
New Delhi
008
Sankara Nethrayala, India
017 Rio de Janeiro, Brazil
009
Prabha Eye Institute, India
018 Pierre and Marie Curie University,
Paris
025 Ramon y Cajal University
Hospital, Spain
027 UNMC, Nebraska, USA
Methods – Web-based Data collection
• Real-time updates of primary data set
• Interactive platform programmed as a smart form
• Compulsory data points
• Smart phone optimisation – data entry via convenience of smartphones
Methods – Data protection
• Patient confidentiality – no patient Identifiers
• One-way site traffic into the Data set, preventing file corruption by viruses
• Entire data set saved and stored securely at regular intervals
Methods - Recruitment
• Inclusion criteria
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Patient records from initial presentation to at least 1 year follow-up
Results of supporting ancillary investigations
Minimum of 1 year follow-up (for COTS-I, between Jan’05 – April’14)
Diagnosis of presumed ocular tuberculosis – satisfying this criteria:
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Clinical signs suggestive of ocular TB
Investigations documenting the mycobacterium/ its genome
Corroborative investigations
Exclusion of other Uveitis Entities
• Exclusion criteria: Ocular co-morbidities interfering with media clarity
Authorship policies
• Meeting presentations
• Primary Manuscripts
• Secondary Manuscripts
Thank you
Please feel free to ask any questions
We look forward to this meaningful collaboration with you.