Transcript Bioidentical versus Synthetic Hormone Replacement.

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Conventional, orthodox, allopathic medicine is
expensive, aggressive, invasive and toxic yet
appropriate for people with end organ and
advanced disease. Most of our health care
resources go to fund this type of medicine
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This model or paradigm of medicine
is not appropriate for people who
are relatively healthy or with early
or mild to moderate medical
problems.
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We are genetically programmed on a
biochemical and cellular level to
maintain health and to heal
ourselves (within limits) if we have
the right conditions. Conditions
which allow us to recover some
measure of youthful physiology.
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Inflammation
Oxidation/production of free radicals
Endothelial cell dysfunction
Insulin resistance
Glycation (AGES)
Accumulation of toxins
Down-regulation of hormones
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Macro nutrition
axioms
Essential Micronutrition
Replacement of
individual micronutritional
deficiencies
Optimal sleep
Detoxification
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Aerobic exercise
Anaerobic (resistance)
exercise
Hormone
replacement (to
optimal, youthful
levels)
Telomere lengthening
(telomerase
activators)
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Stem cell transplant
Platelet rich plasma
(PRP)
Low dose naltrexone
GcMAF
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No junk food.
Avoid food toxins.
Never let yourself get severely hungry.
Eat every 3 hours.
Always eat a big breakfast
Intermittent fasting
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Eat most of the daily carbohydrate intake in the
first part of the day.
No GMO.
Avoid most grain especially wheat.
Best diet is probably the Paleolithic diet
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The genetic engineering process creates
massive collateral damage, causing mutations
in hundreds or thousands of locations
throughout the plant’s DNA. Natural genes
can be deleted or permanently turned on or off
and hundreds may change their behavior.
Even the inserted gene can be damaged or
rearranged. It may create proteins that can
trigger allergies are promote disease.
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Soy
Corn
Canola
cotton
Sugar beats
Wheat
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Can make you allergic to non GMO as well as
GMO foods
Causes liver atrophy in rats
Increases mortality in the rat model
Causes small-for-date offspring and a
decreased number of offspring
Rats fed GMO had altered testicles, ovaries and
germ cells
Third-generation offspring were infertile and
showed increased numbers of tumors
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High fructose corn syrup
High GI carbohydrates
Trans-fats
Fried foods
Foods high in Nacl
Soda/sugary sweets
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Herbicides
Pesticides
Insecticides
Fertilizers
Petrochemicals
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Halides
Heavy metals
BPAs
Phthalates
PVCs/PCBs/PBDE
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MSGs
Aspartame
Solvents
Antibiotics
Synthetic estrogens
Nitrates and nitrites
Glyphosate(Roundup)
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Disruption of mitochondrial function
Decreases ATP production
Causes insulin resistance and hyperglycemia
Chronic hyperglycemia results in AGES
Glyphosate itself breaks down into dioxalate
which also increases AGES
Enhances glycosylation of LDL cholesterol
Increases cerebral glutamate concentration
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Enhances aluminum movement into the brain
Interferes with vitamin D hydroxylation
Reduces the beneficial bacteria in the soil
Reduces pyrole production by intestinal flora
Causes dysbiosis
May increase serum ammonia level
Inhibits cytochrome P450 system
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30-40% Carbohydrates
40% Protein
20-30% Fat
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Organically grown fruits and vegetables
Eliminate most grains
No wheat
Trend toward low GI
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Whole grain wheat has a GI of 72
Cross bred with other wheat grasses
Extensively mutated
Spliced with genetic material from other
organisms.
Gluten/gliadin/wheat germ agglutinins
Causes: belly fat, colon leak, autoimmune
problems, neuropsychiatric problems
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Wild fish
Free range chicken
Free range turkey.
Grass fed beef.
Buffalo/elk
Whey isolate
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Up to 20-30% animal fat.
Omega-3 fat.
We get enough Omega 6 fat.
Supplement with Omega 9 fat (mono-saturated
fat)
No trans-fat
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Multiple vitamin
Vitamin C
Vitamin D3.
Omega 3 fatty acids.
Polyphenols
Iodine.
Replete individual deficiencies
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Needed because soils are depleted in vitamins,
minerals, coenzymes, cofactors and trace
elements
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Collagen A and C/bone matrix
Carnitine synthesis
Immune system
Adrenal hormone production
Parent antioxidant
5000 mg a day
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Not a vitamin
A secosteroid
Up regulates 1/10 of the entire human genome
Needed for vitamin D binding protein/
GcMAF
Produces CAMP
Usually low or suboptimal
Hard to overdose
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Increased incidence of cancer
Cardiovascular disease
Autoimmune disease
Type 2 diabetes mellitus
Metabolic syndrome
Neurocognitive disease
Osteoporosis
Osteoarthritis
Chronic fatigue/fibromyalgia
Influenza
Depression
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Optimal ratio of Omega 6: Omega-3 is 2:1 to 4:1
Ensures that a arachidonic acid is not excessive
and downstream series 2 eicosanoids are
limited
Series 1 and series 3 eicosanoids therefore
predominate suppressing inflammation,
vasoconstriction and platelet aggregation
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Catechins and cyanidins
Antioxidant/free radical scavenger’s
Decrease a large component of the bodies
inflammation
Slow telomere shortening
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Green tea extract
EGCG
Resveratrol
Quercetin
Pycnogenol
Red wine extract
Grapeseed extract
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Deficient in 96% of the American population.
Average intake in US is 175 ug/day
Average Japanese intake is 13,800 ug/day
Concentrates in the thyroid gland.
Also concentrates in the breast , ovaries, uterus
prostate, stomach, pancreas, etc.
Deficiency is thought to be a causative factor in
fibrocystic breast disease, PCOS, uterine
fibroids
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Inverse relationship of iodine level and LV
function, elevated CRP, dyslipidemia,
cardiovascular disease
Is a cofactor for insulin receptors and up
regulates insulin receptors
Needed to synthesized thyroid hormones and
conversion of T4-T3.
Needed for steroid hormone function
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Chelates heavy metals
Displaces and removes toxic halides.
Is a broad-spectrum antimicrobial.
Causes apoptosis of cancer cells and senescent
cells
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Bowel cleanse
Liver cleanse
Increased intake of purified water
Regular heavy exercise and sweating
Infrared sauna
Chelation therapy
Eat only organic food
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Usually mesenchymal stem cells(MSCs)
Are pluripotent and can differentiate into a
variety of cell lines
Work predominantly by secreting cytokines
which up regulate host MSCs
This results in the reduction of inflammation,
modulation of the immune system and
stimulation of regeneration
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Autism
Cerebral palsy
Congestive heart failure
COPD
Asthma
Degenerative joint disease
Spinal cord injury
MS, rheumatoid arthritis, SLE, type 1 diabetes
mellitus, Crohn’s disease, Sjogren’s syndrome,
primary biliary cirrhosis and other autoimmune
diseases
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Plasma is spun to yield the platelet rich
component
The platelet rich component is treated with
fibrin and calcium chloride to activate the
platelets and release growth factors
It is then injected (preferably with ultrasonic
guidance) into an area of injury
This results in tissue (cartilage, tendon, bone)
regeneration and repair
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Platelet derived growth factor
Transforming growth factor beta
Fibroblast growth factor
Insulin like growth factor 1(IGF-1)
Insulin like growth factor 2(IGF-2)
Vascular endothelial growth factor
Epidermal growth factor
Interleukin-8
Keratinocyte growth factor
Connective tissue growth factor
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Nerve injury
Tendinitis/tenosynovitis
Osteoarthritis
Recurrent ankle sprains
Sacroiliac joint dysfunction
Muscle injury
Cardiac muscle injury
Partially torn or strained knee ligaments
Partially torn tendons
Bone repair and regeneration
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Given at bedtime and at doses of 1.5-3 mg it
transiently blocks opioid receptors
This up regulates endorphins and enkephalins
by 200-300%
This up-regulates and simultaneously
modulates the immune system
Large number of anecdotal reports and small
clinical trials with LDN have shown stunning
efficacy in the treatment of various cancers and
auto-immune diseases
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Bladder cancer
Breast cancer
Carcinoid
Colorectal cancer
Glioblastoma
Liver cancer
Non-small cell lung cancer
Chronic lymphocytic leukemia
Lymphoma (Hodgkin’s and non-Hodgkin’s)
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Malignant melanoma
Multiple myeloma
Neuroblastoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cell carcinoma
Throat cancer
Uterine cancer
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ALS
Alzheimer’s dementia
Autism
Multiple sclerosis
Parkinson’s disease
Primary lateral sclerosis
Ankylosing spondylitis
Behcet’s disease
Breast syndrome
Crohn’s disease
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Number metal myositis
Fibromyalgia
Hashimoto’s thyroiditis
Chronic fatigue syndrome
Myasthenia gravis
Primary biliary cirrhosis
Psoriasis
Rheumatoid arthritis
Scleroderma
Sjogren’s syndrome
Systemic lupus erythematosus
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Occurs when vitamin D binding protein
becomes glycosylated with galactosamine at
amino acid position 420
GcMAF markedly up regulates macrophages
Macrophages are then able to identify cancer
cells and viruses and phagocytize them
Cancer cells and viruses produce an enzyme
alpha-N galactosaminidase (nagalase) which
deactivates GcMAF
Adding GcMAF in sufficient quantities can
overwhelm nagalase
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GcMAF has been found to have a number of
other actions against cancer
It causes apoptosis of cancer cells
It inhibits angiogenesis of tumors
It inhibits metastasis
It stimulates the transformation of cancer cells
back to its normal phenotype
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BIHRT makes more intuitive sense
Better results
Little or no side effects
People feel better and function better on them.
Physiologic aging is slowed (often
dramatically)
They are identical to the hormones which
already exists in the body
We don’t have receptors sites for synthetic
hormones
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Progesterone
Testosterone
Cortisol
DHEA
Free T4/T3
HGH/IGF-I
Estradiol
Estriol
Melatonin
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Vasopressin
Oxytocin
MSH
Pregnenolone
Calcitonin
Parathyroid hormone
Aldosterone
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E1–estrone
E2–estradiol
E3–estriol
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Promotes bone mineralization (inhibits
osteoclasts)
Thickens skin by promoting collagen buildup
Maintains integrity of teeth and gums
Increases basal metabolic rate
Improves insulin receptor response
Promotes T4 conversion to T3
Improves vascular elasticity
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Improves arteriolar vasodilation.
Improves blood flow
Inhibits platelet aggregation
Prevents atheroma formation.
Lowers LDL cholesterol.
Lowers Lipoprotein a
Lowers blood pressure
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Decreases homocysteine levels.
Increases ACH by increasing choline acyltransferase activity
Improves reasoning.
Improves mood.
Improves concentration
Improves fine motor skills.
Stimulates nerve growth factor
Enhances libido
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Increases body fat
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Increases triglycerides
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Causes insulin resistance and elevated blood sugar
Increases blood pressure
Increases inflammatory cytokines and CRP
Increases fibrinogen and a tendency to form
thrombosis
Increases risk of gallbladder stones
Interferes with growth hormone effect on the liver
to make IGF-I
Increases production of 4(OH)estrone
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Between the ages of 35 and 50 women
gradually make less estrogen (approximately
35% decrease) but make significantly less
progesterone and testosterone (approximately
75% decrease) resulting in a condition of
estrogen dominance
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Synthetic estrogens.
Xeno- estrogens.
Phytoestrogens
Low iodine levels.
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Come from pesticides, herbicides, plastic
byproducts etc.
May account for severe estrogen dominance in
women
May account for the pandemic of low
testosterone in men
May account for early menarche in girls
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PMS
Anxiety, agitation
Depression
Insomnia
Fluid retention
FBD, PCOS, uterine fibroids, endometriosis
Mood swings
Pain/fibromyalgia/chronic
fatigue/migraines
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Heavy periods
Diminished libido
Abdominal fat gain
Hypothyroidism
Gallbladder disease
Thrombus formation
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Night sweats
Hot flashes
Brain fog
Memory lapses
Fatigue
Urogenital symptoms
Palpitations
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Decreased libido
Vaginal dryness/dyspareunia
Weight gain
Acne
Hair loss
Depression
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Do not need estrone
No receptors to synthetic estrogens.
Problems with oral estrogen(see above)
Administer topically.
Premarin is desiccated pregnant mare’s
urine
Premarin is high in estrone, high in horse
estrogen, and given orally
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Estriol
Progesterone
Testosterone
DHEA
Melatonin
Oxytocin
Free T3
Human Growth Hormone
Vitamin D3
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Estradiol metabolizes to 2(OH) estrone which is
a cancer protective metabolite. It also
metabolizes to 16(OH) estrone and 4(0H)
estrone which or cancer promoter metabolites
A number of botanicals, vitamins and
supplements push estradiol toward the 2(OH)
estrone pathway and away from the 4(OH) and
16(OH)estrone pathways
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B6, B12, Folate
Sulfur containing amino acids/peptides
(methionine, acetylcysteine, trimethylglycine,
SAMe)
Cruciferous vegetables
DIM, 3IC
Omega-3 fatty acids
OPCs/other antioxidant free radical scavengers
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Increases HDL cholesterol
Decreases LDL cholesterol
Up regulates insulin receptors
Lowers blood pressure
Decreases inflammatory cytokines
Increases elasticity of arterial vessel walls
Causes diuresis by blocking aldosterone
receptors
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Protects against breast cancer
Vasodilates coronary artery
Promotes sleep
Increases parasympathetic tone.
Activates neuronal stem cells to increase
neurons.
Protects of brain against traumatic brain injury
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Mitigates DUB
Increases VO2 max
Increases conversion of T4-T3
Improves migraine headaches in estrogen
dominant women
Improves libido in estrogen dominant women
Raises pain threshold
Improves immune system function
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Both men and women need it.
Current worldwide pandemic of low testosterone.
Causes of low testosterone include:
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Traumatic brain injury
Xenoestrogens
Phytoestrogens
Synthetic estrogens
Heavy metals/other causes of inflammation
High stress (cortisol)
High or low thyroid hormone levels
Conditions which activate aromatase
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Decreased libido
Erectile dysfunction
Increase and visceral and belly fat
Gynecomastia
Decreased strength
Decreased endurance
Anxiety/depression
Cognitive dysfunction
Poor sleep
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Fatigue
Mood swings
Urogenital symptoms
Dry skin/sagging skin
Decreased facial and body hair
Joint and muscle pain
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Risk factor for Alzheimer’s dementia.
Risk factor for cardiovascular disease and death
secondary to cardiovascular disease
Osteoporosis and bone fractures
Sarcopenia
Decreased cardiac output/hypertension
Elevated CRP
Dyslipidemia
Insulin resistance
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Sarcopenia
Fat gain especially visceral fat
Likely risk factor for prostate cancer
Decreased libido
Erectile dysfunction
Decreased cardiac output
Increased inflammation
Mild anemia
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Muscle anabolism.
Lipolysis (fat loss)
Bone mineralization
Improved cognitive function
Improved mood
Better sleep
Improved libido
Improved erectile function
Improved cardio vascular function
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Increased differentiation of bone marrow
stem cells to form endothelial progenitor
cells (EPCs)
Up regulation of insulin receptors with
decrease in insulin levels
Marked reduction of inflammatory
cytokines
Lower fasting blood sugar, fasting blood
insulin and lipid levels
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Lose body fat
Decrease alcohol intake, especially beer
Paleolithic diet
Heavy resistance training
Stimulate luteinizing hormone release of the
pituitary by:
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Tribulis terrestris
Avena sativa
D-aspartic acid
SERM (clomiphene)
Bromocriptine/ Cabergoline /zinc
Human chorionic gonadotropin
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Optimal estrogen and progesterone levels
Optimal thyroid levels
Optimal cortisol levels
Increased (optimal) growth hormone levels
Inhibit aromatase
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Progesterone(slight effect).
Zinc
DIM
Chrysin
Anastrozole
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Inhibits testosterone conversion to DHT.
Inhibits testosterone conversion to estradiol
(slight).
Metabolizes to 5-allopregnenolone
Allopregnenolone promotes sleep and reduces
cortisol
Lower cortisol increases luteinizing hormone
and turns off aromatase.
Converts estradiol to estrone
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The active form of thyroid hormone.
Optimal levels stimulate production of
testosterone.
Optimal levels acts synergistically with
testosterone.
High or low levels will activate aromatase
High levels will inhibit testosterone conversion
to dihydrotestosterone
High levels increased sex hormone binding
globulin (SHBG)
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Optimal cortisol level has a positive affect on
the release of testosterone
High cortisol levels inhibit the release of
luteinizing hormone
High cortisol levels activate aromatase
Low cortisol levels increase the level of sex
hormone binding globulin
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Stimulates release of testosterone directly.
Increases, IGF-I, which augments increase of
luteinizing hormone
Inhibits aromatase
Reduces SHBG
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Don’t give testosterone if active cancer present
Digital rectal examination and PSA done on
first visit and periodically thereafter
Follow CBC/ testosterone can increase
hemoglobin levels
Check DHT levels
Check free and total testosterone levels
Check estradiol levels
Free testosterone: 18-24 pg/mL
Total testosterone: 800-1100 ng/mL
Dihydrotestosterone: 50-80 ng/mL
Estradiol: 20-35 pg/mL
Bioavailable testosterone: 300-500 ng/mL
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Total testosterone: 50-100 ng/ml
Free testosterone: 1-6 (2-8) pg/ml
Bioavailable testosterone: 10-30 ng/ml
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Use bio-identical hormones rather than synthetic or
animal hormones
Give estrogen and testosterone as a topical cream
Give progesterone as micronized capsules orally at
bedtime
Give estriol with estradiol
Mimic normal youthful physiologic levels
Pap, pelvic, mammogram prior to starting therapy
Supplement and balance other hormones into
youthful range
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Necessary as principal anti-inflammatory in
the body
Will die without it
Severe low levels referred to as adrenal
insufficiency (Addison’s disease)
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Profound fatigue/decreased level of
consciousness
Hypotension
Hypoglycemia
Hyponatremia
Type IV renal tubular acidosis
Positive diagnosis by ACTH stim test
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Chronic emotional or physiologic stress
Chronic disease
Chronic depression
Chronic pain
Poor nutrition
Excessive exercise
Inadequate rest
High intake of sugar
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Severe fatigue (worse in the morning )
Difficulty recovering from exercise
Agitation and irritability
Depression and anxiety
Orthostatic hypotension
Symptoms of hyperadrenergia
Salt and sugar cravings
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Narcotic intolerance
Decreased libido/sexual dysfunction
Diffuse bone and muscle pain
Food allergies
Seasonal rhinitis/asthma
GI disturbance (GERD and IBS)
Palpitations
Sleep disturbance
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Removed stressors if possible
Optimize diet (Paleolithic/Mediterranean diet)
Decrease or stop caffeine and alcohol
Exercise
Deep sleep(treat with progesterone/melatonin)
Up regulate testosterone to optimal levels
Up regulate DHEA, pregnenolone and
progesterone to optimal levels
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Eventually correct thyroid hormones if low
Multiple vitamin, high-dose vitamin C, highdose chromium, vitamin D3 at 5-10,000 units
per day, Omega 3 fatty acids, etc.
Botanicals/adaptogens
Glandular extracts (adrenal rebuilder)
Consider low-dose cortisol for 1-3 months
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May be due to chronic stress, but eventually
down regulates to suboptimal levels
referred to as adrenal fatigue
High cortisol can also be caused by
Cushing’s disease or Cushing’s syndrome
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Hypertension.
Insulin resistance/type 2 diabetes mellitus
Dyslipidemia/metabolic syndrome
Suppression of the immune system
Sarcopenia (muscle wasting)
Abdominal fat (visceral adiposity)
Osteoporosis (bone demineralization)
Direct neurotoxicity (especially to the
hippocampus)
Dysmorphic features (moon face, buffalo hump,
striae)
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In youth, when stressed, the pituitary
produces ACTH which stimulates the
adrenal gland to release cortisol and
concurrently to release abundant amounts of
DHEA which functions, among other things,
to oppose the many harmful effects of high
cortisol
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Decrease his blood pressure
Up-regulates insulin receptors and decreases
insulin as well as blood sugar
Inhibits the development of dyslipidemia and
metabolic syndrome
Up-regulates the immune system.
Prevents sarcopenia
Prevents visceral adiposity
Stimulates bone mineralization
Protects the brain and promotes cognitive function
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While cortisol may rise slightly or decline
slightly or stay the same with aging, DHEA
typically declines dramatically with aging.
By the age of 50, many people have less than
25% of their youthful levels
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Typically, patients with adrenal fatigue have
concurrent low levels of DHEA and often
low levels of other hormone such as
progesterone, testosterone, pregnenolone
and thyroid hormones
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Pregnenolone is the parent steroid hormone
synthesized in the adrenal gland from
cholesterol and gives rise to the entire
adrenal cascade of hormones
Pregnenolone is produced de novo in the
brain and significantly up regulates ACH
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The parent hormone of the adrenal cascade
Balances the inhibitory and stimulatory
neurotransmission in the brain
Up regulates the stress response
Improves fatigue
Improves memory/cognitive function
Down regulates pain sensation
Up regulates the immune system
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Decreased memory
Fatigue
Cold intolerance
Dry skin
Depression
Increased pain issues
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Arthritis
Depression
Fatigue/adrenal fatigue
Decreased energy states
Mood swings
Fibromyalgia
Postpartum depression
Spinal cord injuries
Impaired memory
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Diagnoses is usually presumed if the TSH >
3iu/ml.
TSH is the pituitary’s response to insufficient T4
and T3(in the pituitary and the brain)
Other typical criteria is a low freeT4
(however T4 is a pro-hormone)
A free T3 of between 3.5 and 4.4 pg/ml is the
best indicator of optimal thyroid function
Unfortunately a free T3 is rarely ordered
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It stimulates cellular DNA to make messenger
RNA which in turn makes ribosomal RNA
Ribosomal RNA codes for the production of
uncoupling proteins
These proteins uncouple oxidative
phosphorylation which is thermogenic
Optimal levels of free T3 are also anabolic for
protein, stimulate glycogenesis and lipolysis
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Fat gain.
Difficulty losing weight/fat
Cold intolerance
Fatigue and low energy
Decreased cognitive function
Dry skin
Constipation
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Fluid retention
Anxiety and depression
Muscle joint and tissue pain
Brittle, thinning hair
Inability to sweat with exercise
Loss of appetite
Heavy menses
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Palpitations/arrhythmias
Recurrent headaches
Dyslipidemia
Signs and symptoms of estrogen dominance
Hypotension/hypertension
Diminished hearing
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Decreased body temperature
Narrowing of the pulse pressure/bradycardia
Periorbital edema
Hertogue’s sign
Thick tongue
Hoarseness
Goiter/enlarged thyroid
Hyporeflexia
Cold hands and feet
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Age
Decreased nutrition
Inflammation
Acute illness
Chronic illnesses
Alcoholism
Heavy metals
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Fertilizers, pesticides and insecticides
Vitamins A,C and B vitamin deficiencies
Depletion of the following minerals:
Selenium
 Zinc
 Iodine
 Iron
 Chromium
 Copper
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Amiodarone
Beta blockers
Oral estrogens
Birth control pills
Lithium
Radioiodine
Aminophyllin
Dilantin
Corticosteroids
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Alpha lipoic acid
Type 2 diabetes mellitus
Obesity
Halide toxicity
Recent x-ray therapy
Recent surgery
Positive TPO antibody status
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Cigarette smoking.
Low level of hGH
Hemochromatosis
High cortisol levels
Chemotherapy
Elevated level of bioflavonoids/soy
products
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T4/T3 (thyroid Armour /Nature-thyroid vs.
conjugated T4/ T3)
Vitamin/mineral supplementation
Replete iodine (Iodoral at 12.5-50 mg a day)
If cortisol depleted, replete it first
Optimal nutrition/exercise
Replete other hormones if low with bioidentical hormones
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Thin skin
Sagging skin
Wrinkles
Hair loss
Graying hair
Decreased short-term memory
Difficulty learning new information
Worsening presbyopia
Anxiety/depression
Poor/nonrestorative sleep
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Decreased endurance
Increased belly fat
Increased visceral fat
Loss of muscle mass and strength
Osteoporosis/osteopenia
Decreased libido/erectile function
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Elevated CRP/elevated IL-6
Elevated lipoprotein a
Dyslipidemia
Increase beta amyloid
Elevated homocysteine level
Decreased NO production
Decrease conversion of T4-T3
Insulin resistance
Down-regulation of all other hormones
Decreased basal metabolic rate
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Somatostatin
Prolactin
Elevated hGH/ IGF-I
Increased fat intake
Increased carbohydrate intake
Elevated cortisol
Obesity/sedentary lifestyle
Oral estrogen
Tamoxifen
Tetracycline
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Growth hormone releasing hormone (GHRH)
Sermorelin/CJC 1295
Ghrelin/GHRP-1, 2, 6, Ipamorelin, Hexarelin
Heavy resistance training
High-protein/decrease carbohydrate and fat
Testosterone
Optimal E2, P4, DHEA, melatonin
Dopamine and serotonin
Amino acids stacks
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Improved hippocampal function (improved
memory learning)
Improved vision
Improved skin fold-thickness
Improved cardiac output/decreased systemic
vascular resistance
Improved vital capacity and VO2 max
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Increased muscle mass
Decreased visceral fat
Increase bone mineral density
Improved RBF and GFR
Improved cytochrome P-450 function
Marked up-regulation of the immune system
including regeneration of the thymus
Increases interferon gamma
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Needed for sleep
Facilitate cycling through the stages of sleep
Potent antioxidant/free radical scavenger
Potent anti-inflammatory agent
Protects the brain against beta amyloid
Is potent anti-carcinogen
Up regulates the immune system
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Increases lab rat age by 30% over controls
Up regulates insulin receptors
Lowers CRP
Increases cardiac output and lowers BP
Increase his HDL cholesterol
Lowers LDL cholesterol
Inhibits LDL cholesterol oxidation
May have an antidysrythmic effect
Stimulates bone mineralization
Enhances release of hGH/IGF-I
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Dosage: 1-10 mg by mouth at bedtime daily
Usually very effective for sleep at high enough
dosages
By age 50 most patients make very little
Often times works well in conjunction with an
appropriate dose of progesterone at bedtime
Consider use of melatonin for sleep in the
younger population
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Decreased with age
Decreased with stress
May be decreased with electromagnetic
radiation
Release augmented with darkness and
inhibited by light
Low levels currently seen in younger
population