Transcript 천연물 약리 및 독성학

천연물 약리 및 독성학
Pharmacology and Toxicology of
Natural Products
장일무
서울대학교 천연물과학연구소
Development of Life Science
from 19th C to 20th C
• Anatomy(Body Structure)
– Histology (tissue)
– cytology(cell)
– Developmental
Anat.(Prenatal devl.)
– Gross, Surface Anat.
– Comparative
Anat.(humans vs
animals)
• Physiology(Function)
– systems phy.(renal, GI)
– Cell Phy.
– Immunology(Defense)
Integration and Development
• Anatomy
+
• Physiology
– Medical Phys. (phys.
Dysfunction and
diseases
Radiology(structure/function of organs within living body
Pathology (Diseased tissue)
Pharmacology(Drug Action in the body)
•biochemistry, molecular biology, microbiology natural
products chemistry & informatics, plant physiology
Classification of Organisms
• Kingdom (Plant and Animal)(animal-eucaryotic cells that
lack walls, plastids,and photosynthetic pigments
• Phylum (Chordata): Dorsal hollow of nerve cord
• Subphylum (Vertebrata) : Vertebral column
• Class (Mammalia) : mammary glands, and hair
• Order (Primates) : brain and prehensile hands
• Family (Hominidae) Large cerebrum, bipedal locomotion
• Genus (Homo) : Flattened face, prominent chin and nose
with inferiorly positioned nostrils
• Species (Sapiens) : Largest cerebrum
• Sub-species
Body Cavity
• Posterior Cavity
– Cranial Cavity
– Vertebral Cavity
• Anterior Cavity
– Thoracic Cavity
– Abdominopelvic Cavity
• Abdominal Cavity
• Pelvic Cavity
Normal Range of Blood
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Arterial PH
Bicarbonate
Sodium
Calcium
Oxygen
Urea
AA’
Protein
Total Lipids
Glucose
7.35-7.43
21.3-28.5 mEq/L
136-151 mEq/L
4.6-5.2 mEq/L
17.2-22.0 ml/100 ml
12-35 mg/100 ml
3.3-5.1 mg/100ml
6.5-8.0 g/100ml
350-850 mg/100 ml
75-110 mg/100 ml
Terminology derived Greek and Latin
• Vermis-worm, cochlea-snail shell, cancer-crab, uvula-grape (동식물 )
• thyroid-shield, xiphos-sword, thorax-breastplate, Sella-saddle, stapesstirrup (전쟁도구나 환경)
• Directional terms for the Human Body
– Superior(toward the top), inferior(toward to the bottom),
anterior(front), posterior (back), medial (midline), lateral(the side
of body), internal (deep), external(outside), Proximal(근접,
toward to the mail mass), Distal (away from main mass), visceral
(related to internal organs), parietal (related to the body wall)
• Singular and Plural
– axilla-axillae, Thorax-thoraces, lumen-lumenia,cortex-cortices,
diagnosis-diagnoses, epididymis, epididymides, appendixappendices, carcinoma-carcinomata, mitochondrionmitochondria, cilium-cillia, tarsus-tarsi, corpus-corpora, viscusvicera, pharynx-pharynges, ovary-ovaries