Transcript Lymph Glands (lymphoglandulae)

Lymph Glands (lymphoglandulae)
After initial maturation in the primary immune organs, "virgin" B and T lymphocytes
are released into the peripheral blood and home to specific sites within the lymph
node (and the other secondary organs), controlled by incompletely understood
homing receptors.
The sites of B cell homing include:
1. The primary and secondary follicles of the lymph node cortex-the sites of antigen
presentation to B cells, and subsequent proliferation and differentiation in response to
same.
2. The medullary cords, where plasma cells aggregate, and release their
immunoglobulins into the efferent lymph.
Lymph Glands (lymphoglandulae)
The site of T cell homing is the paracortex.
Normal lymphocytes recirculate, passing from blood into and through the lymph
nodes, and then into efferent lymphatics, surveilling for the presence of the antigen
for which they have a unique and specific receptor on their surface
If this antigen is not present, the lymphocytes leave the node.
Virgin lymphocytes have a finite lifespan, numbered in weeks, unless they come in
contact with antigen.
Lymphatic circulation
Lymph circulates to the lymph node via afferent lymphatic vessels and drains into the
node just beneath the capsule in a space called the subcapsular sinus.
The subcapsular sinus drains into trabecular sinuses and finally into medullary
sinuses.
The sinus space is criss-crossed by the pseudopods of macrophages which act to trap
foreign particles and filter the lymph.
The medullary sinuses converge at the hilum and lymph then leaves the lymph node
via the efferent lymphatic vessel towards either a more central lymph node or
ultimately for drainage into a central venous subclavian blood vessel, most via
Virchow's node and Ductus Thoracicus.
The Lymph
Found only in the closed lymphatic vessels.
It’s transparent, colorless, or slightly yellow, watery fluid of specific gravity about 1.015; it
closely resembles the blood plasma, but is more dilute
Lymph should be distinguished from “tissue fluid” which is found outside the lymphatic
vessels in the tissue spaces.
Lymph nodes of the arm
These drain the whole of the arm, and are divided into two groups, superficial and
deep.
Deep lymph glands of the arm: These comprise the axillary glands, which are 20-30
individual glands and can be subdivided into:
◦
◦
◦
◦
◦
Lateral glands
Anterior or pectoral glands
Posterior or subscapular glands
Central or intermediate glands
Medial or subclavicular glands
Superficial lymph glands of the arm:
◦ Supratrochlear glands: Situated above the medial epicondyle of the humerus, medial
to the basilic vein, they drain the C7 and C8 dermatomes.
◦ Deltoideopectoral glands: Situated between the pectoralis major and deltoid muscles
inferior to the clavicle.
Lymph Nodes of The Leg
The superficial inguinal lymph nodes:They receive as afferents lymphatic vessels from the following:
• Integument of the penis
• Scrotum
• Perineum
• Buttock
• Abdominal wall below the level of the umbilicus
• Vulva
• Anus (below the pectinate line)
• The lower extremity (foot, leg and thigh)
They are divided into three groups:
• Supramedial or Superomedial
• Superolateral
• Inferior
1. Supromedial superficial inguinal
2. Superolateral superficial inguinal
3. Inferior superficial inguinal
4. Deep inguinal lymph nodes
Lymph Nodes of The Leg
The deep inguinal lymph nodes:-
The deep inguinal lymph nodes drain superiorly to the external iliac lymph
nodes, then to the pelvic lymph nodes and on to the para-aortic lymph nodes.
1. Supromedial superficial inguinal
2. Superolateral superficial inguinal
3. Inferior superficial inguinal
4. Deep inguinal lymph nodes
THANKS
Dr. Ryan AL.Ghanemi