Transcript **** 1 - in-cosmetics Asia

Introduction of
PTD Technology
The Structure of Human Skin
1. Epidermis
Is the outermost layer of the skin and protective wrap over the body’s surface
2. Dermis
Is the layer of skin beneath the epidermis that consists of connective tissue and
cushions the body from stress and strain.
3. Subcutis
Due to the protective role of dermis and epidermis, absorption of skin care cosmetics is
not easy
Protein Transduction Technology
Intracellular
Plasma membrane
Extracellular
* PTD carrier makes efficient protein deliver into the cell
* Transdermal delivery of a biologically active protein: 2001 Nature Biotechnology (Morris Group) *
Macromolecules such as Protein, DNA and Peptide are very difficult to transfer into the
cells.
However, PTD (Protein Transduction Domain) technology enables effective transfer of
these macromolecules possible. We developed 1:1 conjugated PTD and Growth factors
such as PTD-EGF(Trade name : SP1-EGF) and PTD-FGF1(Trade name : SP1-FGF1). Our’s
PTD technology is superior in terms of using native protein and superior permeability.
Core Technology
Normal Growth factor
SP1-Growth Factor
PTD
PTD
PTD
PTD
PTD
PTD
1
PTD + Growth Factor
2
Penetration
3
Efficient Delivery
4
Skin Renewal
(EGF, FGF1)
Core technology of this product is PTD technology enabled macromolecules transfer
through the skin into the dermis which results in the increase of skin elasticity and
alleviation of skin winkles (SP1-EGF & SP1-FGF1), and maximize antioxidant effect (SP1SOD)
The Fusion Technology of PTD-Growth Factor
 The world 1st fused PTD - Growth Factor Expression Technology
 Recombinant fusion protein purification Technology
 Refolding Technology while keeping protein activity
 Advanced assay system for physiological activity