Transcript Clinical manifestation

Viral Diseases
Clinical classification
Vesicle form：vesicles dominated,such as
Herpes Simplex ,Herpes Zoster
and Varicella.
Erythema form：Erythema dominated ，such as
Measles、Rubella and
Erythema Infectioum.
Neoplasm form：Verruca vulgaris,Verruca planae
and Molluscum Contagiosum.
STD form：Lymphogranuloma venereum.
Herpes simplex
Vericella
Herpes zoster
Verruca vulgaris
Verruca
plana
Herpes zoster
Zoster is a kind of acute skin infection caused
by the varicella-zoster virus.
Manifestation: unilaterlly ;
within the distribution of sensory nerve;
little blisters in population;
with neuralgia and lymphadenectasis;
less recurrence after recovery
Etiology and Mechanism
varicella-zoster virus.
varicella
infect
human
Latent
infection
Virus in
Indu
the
ganglia cing Herpes
facto zoster
of
cranial rs
or spinal
sensory
nerve
Clinical manifestation
Predilection human beings：adult
Early symptoms ： moderate fever,malaise,local
lymphadenectasis and neuralgia.
Eruption characteristic：
（1）erythema
papule
blister
（2）distribute unilaterally in band
within peripheral nerve
（3）blisters in population
（4）neuralgia and local lymphadenectasis
Predilection sites ： chest,waist,neck and the
distribution regions of trigeminal nerve.
course：
2－4 weeks
Special form Zoster (Ⅰ)
Herpes zoster without eruptions
Abortive type Herpes Zoster
Bullous,hemorrhagic or necrotic
Herpes Zoster
Disseminated Herpes Zoster
Herpes Zoster（hemorrhagic)
）
Special Herpes Zoster（Ⅱ）
virus
Motor neurons
Myasthenia，skin paralysis
virus geniculate ganglion(involvment of the
facial and auditory nerves)
Ramsey－Hunt syndrome :
Zoster of the external ear, ear pain,
facial paralysis, vertigo.
Diagnosis
Lesions:erythema,papule and
blisters;
Blisters in population;
distribute unilaterally in band
within peripheral nerve;
with neuralgia.
Treatment principles
The prevention of neuralgia
antivirus：ACV 0.2 q4h X 5－10d
Valaciclovir 0.3bid X 5－10d
antiinflammation
Topical treatment
Prevent secondary infection
Molluscum contagiosa
papule dermatosis,caused by MCV
characteristics:
smooth
surfaced
and
shaped pearly papules;
central umbilication;
molluscum body.
dome
Etiology and Mechanism
Molluscum Contaguosum Virus
transmitted by
direct skin to skin contact;
or auto-inoculation
Clinical manifestation
Predilection human beings：children and
youth. Latent time: 2-3 weeks.
Feature of lesions：
3 to 5mm in diameter
semisphere-like , pearly papules
central umbilication
squeeze out white cheese-like substance
number: several to many
no confluence
Clinical manifestation
Predilection sites：
trunk, extremities,scrotum and eyelid
sometimes lip, tone and
buccal mucosa are involved.
course：6－9months，
individually:4－5years or longer.
Symptoms: NO or moderate itching.
Treatment
Isolation
Nicking with
acid(33％)
trichloracetic
10％ potassium hydroxide
Scabies
Definition
scabies is one kind of parasitosis
caused by Sarcoptes scabies which invade
the skin of the finger webs,antecubital
fossae, the lower abdomen,genitals and
scrotum ect, and characterized by
pruritic papular, bullous lesions and
also burrows.
transimitted by skin to skin contact
Etiology
Life of Sarcoptes scabies
adult
female
male
3-4
Female ovulate
mating
days
ovum
Male died
larva
2-3
days
Twice ecdysis
nymphae
adult
7-14days
Infection style：mostly direct skin to skin contact，
a few infected by indirect contact
Clinical manifestation：
Predilection human beings：anyone
Feature of eruption：
1 papulovesicles with no confluence
2 burrows
3 scabies nodule
Predilection sites: the finger web,medial wrist,
antecubital fossae,areas around the waist,
the lower abdomen, genitals and groins ect.
Intense itch: especially in night
The finger web
Diagnosis
eruption：burrows
papulovesicles and blisters
scrotum nodules
predilection sites: especially the
finger web and external genitals.
intense itch: especially in night
infect collectively:the same patients
in one family.
most convinced evidence: Sarcoptes
scabies or its eggs.
Differential diagnosis
Pruritus
Papular urticaria
Pediculosis
Treatment
10% Oint. Sulfur
Solution of killing Sarcoptes scabies
Cream. 10％ Crotamiton