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• Croton Lechleri Extract
• Dermis regenerator agent
• Anti Stretch-Mark
CROTON LECHLERI EXTRACT
• Latex resin extract,
typical of Peru and Amazzonia
• Obtained through cortex incision
of the Croton Lechleri tree
• Rich in Taspine, Pro-anthocyanidins, Lignams
• Documented cicatrizing,
anti-inflammatory,
anti-bacterial action
..also known as Sangre de Grado
or Sangre de drago
CROTON
LECHLERI
EXTRACT
ACTIVE COMPONENTS
TASPINE
PROANTHOCYANIDINS
CIKADERM
LIGNAMS
CROTON
LECHLERI
EXTRACT
1 - TASPINE
Alkaloid molecule
responsible
of cicatrizing action
Determines a Chemiotaxis call of fibroblasts in
damaged skin tissue
(..with increase of 56% fibroblast methabolism)
Fibroblasts called in ‘’in loco’’ provide elastic
and mechanical resistance to the dermis, by the
production of new Elastic and Collagen fibers
(Increased level of Collagen I, III, IV, Fibronectin,
Integrin β-4)
CROTON
LECHLERI
EXTRACT
2 - LIGNAMS
Phytoestrogen structure
3', 4-0-dimethyl-cedrusine is able to
preserve the integrity of the
originary tissue subjected to the
damage
Concomitant anti-bacterial action
• ,
CROTON
LECHLERI
EXTRACT
3 – PROANTHOCYANIDINS
Able to reduce inflammatory events on
the skin
Prevention of damage to dermis
component structures
Anti-oxidant activity
Responsable of the speed of the scar
tissue formation, through the induction of
seric protein physical precipitation
• ,
CROTON
LECHLERI
EXTRACT
BIOCHEMICAL INDUCED effects (recap)
• IMPROVEMENT OF STRATIFICATION OF NEW
EPIDERMIS
• INCREASE OF COLLAGEN IV EXPRESSION
• INCREASE OF β4 INTEGRINS EXPRESSION
• INCREASE FIBRONECTINE
• INCREASE COLLAGEN I and COLLAGEN III
EXPRESSION
• ANTI-OXIDANT ACTIVITY
• INCREASE OF 56 % FIBROBLASTS ACTIVITY
.. SIGNIFICANT CICATRIZING
AND SKIN REJUVENATING
ACTION!
CROTON
LECHLERI
EXTRACT
VERY WELL KNOWN COMPONENTS
•
Taspine is the Cicatrizant Principle in Sangre de Grado Extracted from Croton
lechleri. Planta Medica 55 (1989)
•
Isolation of a dihydrobenzofuran lignan from South American dragon’s blood
(Croton SPP.) As an inhibitor of cell proliferation. Journal of Natural Products
Vol.56, No.6, pp. 899-906, June 1993
•
In vivo wound healing activity of Dragon’s Blood (Croton SPP.), a traditional South
American drug, and its constituents. Phytomedicine vol.2 (1), pp. 17-22, 1995
•
Studies on the Anti-Tumour, Anti-Bacterial, and Wound-Healing Properties of
Dragon’s Blood. Planta Medica 60 (1994)
•
Review of Sangre de Drago (Croton lechleri)-A South American Tree Sap in the
Treatment of Diarrhoea,
•
Inflammation, Insect Bites, Viral Infections, and Wounds: Traditional Uses to
Clinical Research. The Journal of Alternative and Complementary Medicine Vol.9,
No. 6, 2003, pp. 877-896
•
Inhibition of Neurogenic Inflammation by the Amazonian Herbal Medicine
Sangre de Grado. The Journal of Investigative Dermatology ( 2001)51-56
PROANTHOCY
ANIDINS
• Alkaloid molecule responsible of cicatrizing action
• Determines a Chemiotaxis call of fibroblasts in
damaged skin tissue
• Fibroblasts called in ‘’in loco’’ provide elastic and
mechanical resistance to the dermis, by the
production of new Elastic and Collagen fibers
CROTON
LECHLERI
EXTRACT
TEXTURE of scar and strecth marks
10 subjects: male and female
(with scars or stretch marks)
between 18-70 years
Cream with Cikaderm @3%
Significant DECREASE of stretch-marks TEXTURE
CROTON
LECHLERI
EXTRACT
APPEARANCE of scar and strecth marks
10 subjects: male and female
(with scars or stretch marks)
between 18-70 years
Cream with Cikaderm @3%
Significant DECREASE of stretch-marks
COLORATION
CROTON
LECHLERI
EXTRACT
ITCHING (subjective evaluation)
10 subjects: male and female
(with scars or stretch marks)
between 18-70 years
Cream with Cikaderm @3%
Significant DECREASE of the ITCHING perception
CROTON
LECHLERI
EXTRACT
CLINICAL CASE
CROTON
LECHLERI
EXTRACT
PHOTO EVALUATION
Skin stratification
Control
Croton Lechleri extract
Beta-4 Integrin
levels
Control
Croton Lechleri extract
Collagen I
levels
Control
Croton Lechleri extract
CROTON
LECHLERI
EXTRACT
PHOTO EVALUATION
Collagen IV levels
Control
Croton Lechleri extract
Fibronectine
levels
Control
Croton Lechleri extract
Collagen III
levels
Control
Croton Lechleri extract
CROTON
LECHLERI
EXTRACT
CIKADERM
normalizes the
aesthetic appearance
of
scars and stretch marks
by enhancing the
functional parameters
of the skin
CROTON
LECHLERI
EXTRACT
CIKADERM
• Has a eutrophic and regenerative effect
• Increases skin tone and elasticity
• Stimulates faster regeneration of damaged
tissue
• Improves scars appearance
• Has a normalizing effect on scars both
aesthetically and physiologically
• Reduces the sensation of tight skin typical of
recently formed scars
CROTON
LECHLERI
EXTRACT
APPLICATIONS & PLUS
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STRETCH-MARK FORMATION PREVENTION
Healing ‘’PINK-RED’’ STRETCH-MARKS
PHYTOTERAPEUTIC CICATRIZING products
NO SIDE EFFECTS known in literature
SEVERAL TARGETS (Pregnancy, Body Building ,
fast loss of weight based stretch-mark healing)
..GREEN PRODUCT
Thank you
Via Pastore 1 - 25082 Botticino Sera (Brescia) Italy
Tel. +39 0302693532 - Fax. +39 0302193581
www.kalichem.it [email protected]