Transcript postganglionic fibers

Chapter 15
Lecture Outline
15-1
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Autonomic Nervous System
and Visceral Reflexes
• Autonomic Nervous System (ANS)
– general properties
– anatomy
• Autonomic Effects on Target Organs
• Central Control of Autonomic
Function
15-2
Autonomic Nervous System
• portion of the nervous system that operates in
comparative secrecy
• it manages a multitude of unconscious processes
responsible for the body’s homeostasis
• Walter Cannon
– coined the expressions as homeostasis and fight or flight
– dedicated his career to studying the ANS
• homeostasis cannot be maintained without the
ANS
15-3
General Properties of ANS
• autonomic nervous system (ANS) – a motor
nervous system that controls glands, cardiac
muscle, and smooth muscle
– also called visceral motor system
– primary organs of the ANS
– carries out actions involuntarily – without our
conscious intent or awareness
15-4
Visceral Reflexes
•
visceral reflexes - unconscious, automatic,
stereotyped responses to stimulation involving
visceral receptors and effectors and
somewhat slower responses
•
visceral reflex arc
–
•
receptors – nerve endings that detect stretch,
tissue damage, blood chemicals, body
temperature, and other internal stimuli
ANS modifies effector activity
15-5
Visceral Reflex to High BP
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• high blood pressure
detected by arterial
stretch receptors (1),
afferent neuron (2)
carries signal to CNS,
efferent (3) signals
travel to the heart (4),
heart slows reducing
blood pressure
2 Glossopharyngeal
nerve transmits signals
to medulla oblongata
1 Baroreceptors
sense increased
blood pressure
3 Vagus nerve
transmits
inhibitory
signals
to cardiac
pacemaker
Common carotid
artery
Terminal
ganglion
4 Heart rate
decreases
Figure 15.1
15-6
Divisions of ANS
•
two divisions innervate same target organs
–
may have cooperative or contrasting effects
sympathetic division
–
prepares body for physical activity – exercise, trauma,
arousal, competition, anger, or fear
parasympathetic division
–
calms many body functions reducing energy
expenditure and assists in bodily maintenance
•
•
digestion and waste elimination
“resting and digesting” state
15-7
Divisions of ANS
•
autonomic tone - normal background rate
of activity that represents the balance of the
two systems according to the body’s
changing needs
–
parasympathetic tone
•
•
–
sympathetic tone
•
•
maintains smooth muscle tone in intestines
holds resting heart rate down to about 70 – 80 beats
per minute
keeps most blood vessels partially constricted and
maintains blood pressure
sympathetic division excites the hearts
but inhibits digestive and urinary function,
while parasympathetic has the opposite
effect
15-8
Neural Pathways
•
ANS has components in both the central and peripheral
nervous systems
–
–
•
control nucleus in the hypothalamus and other brainstem regions
motor neurons in the spinal cord and peripheral ganglia
somatic motor pathway
–
•
a motor neuron from the brainstem or spinal cord issues a myelinated
axon that reaches all the way to the skeletal muscle
autonomic pathway
–
–
signal must travel across two neurons to get to the target organ
must cross a synapse where these two neurons meet in an autonomic
ganglion
15-9
Somatic versus Autonomic Pathways
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Somatic efferent innervation
ACh
Myelinated
fiber
Somatic effectors
(skeletal muscles)
Autonomic efferent innervation
ACh
Myelinated
preganglionic fiber
ACh or NE
Unmyelinated
postganglionic fiber
Autonomic
ganglion
Visceral effectors
(cardiac muscle,
smooth muscle,
glands)
Figure 15.2
ANS – two neurons from CNS to effectors
• presynaptic neuron whose cell body is in CNS
• postsynaptic neuron cell body in peripheral ganglion 15-10
Sympathetic Nervous System
•
also called the thoracolumbar division because it arises
from the thoracic and lumbar regions of the spinal cord
•
relatively short preganglionic and long postganglionic
fibers
–
lead to nearby sympathetic chain of ganglia (paravertebral
ganglia)
•
•
•
series of longitudinal ganglia adjacent to both sides of the vertebral
column from cervical to coccygeal levels
usually 3 cervical, 11 thoracic, 4 lumbar, 4 sacral, and 1 coccygeal
ganglion
sympathetic nerve fibers are distributed to every level of the body
15-11
Sympathetic Nervous System
–
each paravertebral ganglion is connected to a spinal nerve by
two branches – communicating rami
–
preganglionic fibers are small myelinated fibers that travel
form spinal nerve to the ganglion by way of the white
communicating ramus (myelinated)
–
postganglionic fibers leave the ganglion by way of the gray
communicating ramus (unmyelinated)
•
–
forms a bridge back to the spinal nerve
postganglionic fibers
15-12
Sympathetic Chain Ganglia
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Cardiac n.
Thoracic
ganglion
Communicating
ramus
Bronchi
Superior
vena cava
Sympathetic
chain
Rib
Splanchnic n.
Heart
Phrenic n.
Vagus n.
Diaphragm
© From A Stereoscopic Atlas of Anatomy by David L. Basett. Courtesy of Dr. Robert A. Chase, MD
Figure 15.3
15-13
Sympathetic Nervous System
•
after entering the sympathetic chain, the postganglionic
fibers may follow any of three courses
–
some end in ganglia which they enter and synapse
immediately with a postganglionic neuron
–
some travel up or down the chain and synapse in ganglia at
other levels
–
some pass through the chain without synapsing and
continue as splanchnic nerves
15-14
Sympathetic Nervous System
•
nerve fibers leave the sympathetic chain by spinal, sympathetic, and
splanchnic nerves
–
spinal nerve route
•
•
–
some postganglionic fibers exit a ganglion by way of the gray ramus
returns to the spinal nerve and travels the rest of the way to the target organ
sympathetic nerve route
•
•
•
other nerves leave by way of sympathetic nerves that extend to the heart,
lungs, esophagus and thoracic blood vessels
these nerves form carotid plexus around each carotid artery of the neck
issue fibers from there to the effectors in the head
–
•
–
sweat, salivary, nasal glands, piloerector muscles, blood vessels, dilators of iris
some fibers of superior and middle cervical ganglia form cardiac nerves to
the heart
splanchnic nerve route
•
some fibers that arise from spinal nerves T5 to T12 pass through the
sympathetic ganglia without synapsing
–
–
continue on as the splanchnic nerves
lead to second set of ganglia – collateral (prevertebral) ganglia and
synapse there
15-15
Sympathetic Nervous System
•
collateral ganglia contribute to a network called the
abdominal aortic plexus
–
–
wraps around abdominal aorta
three major collateral ganglia in this plexus
•
•
–
solar plexus – collective name for the celiac and superior
mesenteric ganglia
•
•
celiac, superior mesenteric, and inferior mesenteric
postganglionic fibers accompany these arteries and their branches to
their target organs
nerves radiate from ganglia like rays of the sun
neuronal divergence predominates
– each preganglionic cell branches and synapses on 10 to 20
postganglionic cells
– one preganglionic neuron can excite multiple postganglionic fibers
leading to different target organs
– have relatively widespread effects
15-16
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Efferent
Pathways
Eye
Pons
Salivary glands
Preganglionic neurons
Postganglionic neurons
Heart
Cardiac and
pulmonary plexuses
Regions of spinal cord
Cervical
Thoracic
Lumbar
Sacral
Lung
Celiac
ganglion
Liver and
gallbladder
Stomach
Superior
mesenteric
ganglion
Spleen
Pancreas
Postganglionic fibers to
skin, blood vessels,
adipose tissue
Inferior
mesenteric
ganglion
Small intestine
Large intestine
Rectum
Sympathetic chain
ganglia
Adrenal medulla
Kidney
Figure 15.4
Ovary
Penis
Uterus
15-17
Scrotum
Bladder
Preganglionic Pathways
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Soma of
preganglionic
neuron
To iris, salivary glands,
lungs, heart, thoracic
blood vessels, esophagus
Sympathetic nerve
2
Somatic
motor fiber
Spinal nerve
Preganglionic
sympathetic fiber
Postganglionic
sympathetic fiber
To somatic effector
(skeletal muscle)
1
Soma of
somatic motor
neuron
3
White ramus
Splanchnic nerve
Gray ramus
Preganglionic neuron
Postganglionic neuron
Somatic neuron
Figure 15.5
To sweat glands,
piloerector muscles,
and blood vessels
of skin and
skeletal muscles
Communicating
rami
Collateral ganglion
Soma of
postganglionic
neuron
Postganglionic
sympathetic fibers
Sympathetic
trunk
To liver, spleen, adrenal glands,
stomach, intestines, kidneys,
urinary bladder, reproductive organs
Sympathetic
ganglion
2
15-18
Ganglia and Abdominal Aortic Plexus
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Diaphragm
Esophagus
Adrenal medulla
Adrenal cortex
Celiac ganglia
(b)
Adrenal gland
Celiac trunk
Renal plexus
Superior mesenteric
ganglion
First lumbar
sympathetic
ganglion
Superior mesenteric artery
Aortic plexus
Inferior mesenteric artery
Kidney
Inferior mesenteric
ganglion
Aorta
Pelvic
sympathetic
chain
(a)
Figure 15.6
15-19
Summary of Sympathetic Innervation
• effectors in body wall are innervated by
sympathetic fibers in spinal nerves
• effectors in head and thoracic cavity are
innervated by fibers in sympathetic
nerves
• effectors in abdominal cavity are
innervated by
15-20
Adrenal Glands
• paired adrenal (suprarenal) glands on superior poles of
the kidneys
• each is two glands with different functions
– adrenal cortex (outer layer)
• secretes steroid hormones
– adrenal medulla (inner core)
• essentially a sympathetic ganglion
• consists of modified postganglionic neurons without dendrites or axons
– stimulated by preganglionic sympathetic neurons that terminate on these
cells
• secretes a mixture of hormones into bloodstream
– catecholamines - 85% epinephrine (adrenaline) and 15% norepinephrine
(noradrenaline)
– also function as neurotransmitters
• sympathoadrenal system is the closely related functioning
15-21
adrenal medulla and sympathetic nervous system
Parasympathetic Division
• parasympathetic division is also called the
craniosacral division
– arises from the brain and sacral regions of the spinal cord
– fibers travel in certain cranial and sacral nerves
• origin of long preganglionic neurons
• pathways of long preganglionic fibers
• terminal ganglia in or near target organs
– long preganglionic, short postganglionic fibers
• neuronal divergence less than sympathetic division
– one preganglionic fiber reaches the target organ and then
stimulates fewer than 5 postganglionic cells
15-22
Parasympathetic Cranial Nerves
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Preganglionic neurons
Pterygopalatine
ganglion
Oculomotor n.
(CN III)
Facial n.
(CN VII)
Postganglionic neurons
Ciliary ganglion
Lacrimal gland
Eye
Submandibular
ganglion
Submandibular
salivary gland
Otic ganglion
Parotid
salivary gland
Glossopharynge
al n.
(CN IX)
Vagus n.
(CN X)
Regions of
spinal cord
Cervical
Thoracic
Lumbar
Sacral
– tear, nasal and salivary
glands
Pulmonary
plexus
Esophageal
plexus
Lung
Celiac
ganglion
– narrows pupil and focuses
lens
• Facial nerve (VII)
Heart
Cardiac plexus
• Oculomotor nerve (III)
Stomach
Liver and
gallbladder
Abdominal
aortic
plexus
Spleen
Pancreas
Pelvic
splanchnic
nerves
Kidney and
ureter
Transverse
colon
Descending
colon
Inferior
hypogastric
plexus
Small intestine
• Glossopharyngeal nerve
(IX)
– parotid salivary gland
Rectum
• Vagus nerve (X)
Pelvic
nerves
Penis
Ovary
Uterus
Bladder
Scrotum
Figure 15.7
15-23
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Efferent
Pathways
Preganglionic neurons
Pterygopalatine
ganglion
Postganglionic neurons
Ciliary ganglion
Oculomotor n.
(CN III)
Lacrimal gland
Eye
Facial n.
(CN VII)
Submandibular
ganglion
Submandibular
salivary gland
Otic ganglion
• remaining parasympathetic
fibers arise from levels S2
to S4 of the spinal cord
• form pelvic splanchnic
nerves that lead to the
inferior hypogastric
plexus
Parotid
salivary gland
Glossopharyngeal n.
(CN IX)
Vagus n.
(CN X)
Heart
Cardiac plexus
Regions of
spinal cord
Cervical
Pulmonary
plexus
Esophageal
plexus
Lung
Thoracic
Lumbar
Sacral
Celiac
ganglion
Stomach
Liver and
gallbladder
Abdominal
aortic
plexus
Spleen
Pancreas
Pelvic
splanchnic
nerves
Kidney and
ureter
Transverse
colon
Inferior
hypogastric
plexus
Descending
colon
Small intestine
Rectum
Figure 15.7
Pelvic
nerves
Penis
Ovary
Uterus
Bladder
Scrotum
15-24
Enteric Nervous System
• enteric nervous system –
• composed of 100 million neurons found in the walls of the
digestive tract
• no components in CNS
• has its own reflex arcs
• regulates motility of esophagus, stomach, and
intestines and secretion of digestive enzymes and acid
• normal digestive function also requires regulation by
sympathetic and parasympathetic systems
15-25
Megacolon
• Hirschsprung disease – hereditary defect
causing absence of enteric nervous system
– no innervation in sigmoid colon and rectum
– constricts permanently and will not allow passage of
feces
– feces becomes impacted above constriction
– megacolon – massive dilation of bowel accompanied
by abdominal distension and chronic constipation
15-26
Neurotransmitters and Receptors
• how can different autonomic neurons have different effects?
constricting some vessels but dilating others
– effects determined by types of neurotransmitters released and types
of receptors found on target cells
• 2 fundamental reasons:
– target cells respond to the same neurotransmitter differently
depending upon the type of receptor they have for it
• all autonomic fibers secrete either acetylcholine or norepinephrine
• there are 2 classes of receptors for each of these neurotransmitters
15-27
Acetylcholine (ACh)
• ACh is secreted by all preganglionic neurons in both
divisions and the postganglionic parasympathetic
neurons
– called cholinergic fibers
– any receptor that binds it is called cholinergic receptor
• 2 types of cholinergic receptors
• all cardiac muscle, smooth muscle, and gland cells have muscarinic
receptors
• excitatory or inhibitory due to subclasses of muscarinic receptors
–
• on all ANS postganglionic neurons, in the adrenal medulla, and at
neuromuscular junctions of skeletal muscle
• excitatory when ACh binding occurs
15-28
Norepinephrine (NE)
• NE is secreted by nearly all sympathetic
postganglionic neurons
– called adrenergic fibers
– receptors for it called adrenergic receptors
15-29
Overview
• autonomic effects on glandular secretion are often an indirect
result of their effect on blood vessels
– vasodilation – increased blood flow – increased secretion
– vasoconstriction – decreased blood flow – decreased secretion
• sympathetic effects tend to last longer than parasympathetic effects
– ACh released by parasympathetics is broken down quickly at synapse
– NE by sympathetics is reabsorbed by nerve, diffuses to adjacent tissues,
and much passes into bloodstream
• many substances released as neurotransmitters that modulate ACh
and NE function
– sympathetic fibers also secrete enkephalin, substance P, neuropeptide Y,
somatostatin, neurotensin, or gonadotropin-releasing hormone
– parasympathetic fibers stimulate endothelial cells to release the gas, nitric
oxide – causes vasodilation by inhibiting smooth muscle tone
• function is crucial to penile erection - means of action of Viagra
15-30
Neurotransmitters and Receptors
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(a) Parasympathetic fiber
Nicotinic
receptor
ACh
Target
cell
ACh
Preganglionic
neuron
Postganglionic
neuron
Muscarinic
receptor
(b) Sympathetic adrenergic fiber
Nicotinic
receptor
ACh
Target
cell
Preganglionic
neuron
Postganglionic
neuron
NE
Adrenergic receptor
(c) Sympathetic cholinergic fiber
Nicotinic
receptor
ACh
Target
cell
Preganglionic
neuron
Postganglionic
neuron
ACh
Muscarinic receptor
Figure 15.8
15-31
Dual Innervation
• dual innervation - most viscera receive
nerve fibers from both parasympathetic
and sympathetic divisions
– antagonistic effect – oppose each other
– cooperative effects – two divisions act on
different effectors to produce a unified overall
effect
15-32
Dual Innervation
• antagonistic effects - oppose each other
– exerted through dual innervation of same effector
cells
– exerted because each division innervates different
cells
• pupillary dilator muscle (sympathetic) dilates pupil
• constrictor pupillae (parasympathetic) constricts pupil
15-33
Dual Innervation
• cooperative effects - when two divisions
act on different effectors to produce a
unified effect
15-34
Dual Innervation of the Iris
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Brain
Parasympathetic fibers
of oculomotor nerve (III)
Superior
cervical
ganglion
Sympathetic
fibers
Ciliary
ganglion
Spinal cord
Cholinergic stimulation
of pupillary constrictor
Iris
Adrenergic
stimulation of
pupillary dilator
Sympathetic
(adrenergic) effect
Pupil
Parasympathetic
(cholinergic) effect
Figure 15.9
Pupil dilated
Pupil constricted
15-35
Without Dual Innervation
• some effectors receive only sympathetic fibers
– adrenal medulla, arrector pili muscles, sweat glands and many
blood vessels
• control of blood pressure and routes of blood flow
•
•
•
•
keeps vessels in state of partial constriction
increase in firing frequency - vasoconstriction
decrease in firing frequency - vasodilation
can shift blood flow from one organ to another as needed
• sympathetic division acting alone can exert opposite effects on the
target organ through control of blood vessels
– during stress
• blood vessels to muscles and heart dilate
• blood vessels to skin constrict
15-36
Sympathetic and Vasomotor Tone
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Artery
sympathetic division
prioritizes blood vessels to
skeletal muscles and heart
in times of emergency
1
Sympathetic
nerve fiber
1 Strong
sympathetic
tone
2
2 Smooth muscle
contraction
3
Vasomotor
tone
3 Vasoconstriction
(a) Vasoconstriction
blood vessels to skin
vasoconstrict to
minimize bleeding if
injury occurs during
stress or exercise
1
1 Weaker
sympathetic
tone
2
3
2 Smooth muscle
relaxation
3 Vasodilation
(b) Vasodilation
Figure 15.10
15-37
Control of Autonomic Function
• ANS regulated by several levels of CNS
– cerebral cortex has an influence – anger, fear, anxiety
• powerful emotions influence the ANS because of the connections
between our limbic system and the hypothalamus
– spinal cord reflexes
• defecation and micturition reflexes are integrated in spinal cord
• we control these functions because of our control over skeletal
muscle sphincters…if the spinal cord is damaged, the smooth
muscle of bowel and bladder is controlled by autonomic reflexes
built into the spinal cord
15-38
Drugs and the Nervous System
• neuropharmacology – study of effects of drugs on
the nervous system
• sympathomimetics enhance sympathetic activity
– stimulate receptors or increase norepinephrine release
• cold medicines that dilate the bronchioles or constrict nasal blood vessels
• sympatholytics suppress sympathetic activity
– block receptors or inhibit norepinephrine release
• beta blockers reduce high BP interfering with effects of
epinephrine/norepinephrine on heart and blood vessels
• parasympathomimetics enhance activity while
parasympatholytics suppress activity
15-39
Adenosine and Caffeine
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NH2
N
N
O
H3C
N
N
N
CH3
N
OH O
O
N
N
CH3
OH
Figure 15.11
OH
Adenosine
Caffeine
15-40