Transcript intro

Primer on the Olfactory Bulb and Antennal Lobe
Brief comparative introduction of:
• Neurons
• Synaptic interactions
Olfaction: common evolutionary problems…
…common solutions
The AL and OB: Macroscopic Relations
Brain nerve I
OB projects to various brain centers
J. H. Martin, 1989
The Mammalian Sensory Epithelium
L. Buck and R. Axel (1991)
Cell 65, 175-187
Each olfactory receptor
neuron (ORN) expresses
only one gene coding an
odorant receptor protein.
Fascicles
G. M. Shepherd, 2004
The Insect Sensory Epithelium
OB Intrinsic (local) and Principle (output) Neurons
Synaptic interactions within the OB glomeruli
Synaptic interactions within the AL glomeruli
AL’s
cholinergic
ORN input
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GABAergic
LN’s
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AL glomerulus
BMI-sensitive
Receptors: D.2.2.1
D.2.3.1
D.2.3.3
PN (output)
AL Intrinsic (local) and Principle (output) Neurons
AL
MB
http://www.biozentrum.uni-wuerzburg.de/fileadmin/REPORT/GENET/genet010.htm
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LH