Functional Human Physiology for the Exercise and Sport Sciences
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Transcript Functional Human Physiology for the Exercise and Sport Sciences
Functional Human Physiology
for the Exercise and Sport Sciences
The Nervous System
Jennifer L. Doherty, MS, ATC
Department of Health, Physical Education, and
Recreation
Florida International University
Overview of the Nervous System
Two major anatomical divisions
The central nervous system (CNS)
1)
2)
Brain
Spinal Cord
The peripheral nervous system (PNS)
1)
2)
Afferent Division
Efferent Division
Somatic Nervous System
Autonomic Nervous System
Overview of the Nervous System
Functional Divisions of the PNS
Afferent = Sensory
1) Somatic sensory
2) Visceral sensory
Efferent = Motor
1) Somatic motor
2) Visceral motor
Overview of the Nervous System
Divisions of the PNS according to type of
control
Somatic nervous system
1) Voluntary
Autonomic nervous system
1) Involuntary
2) Further divided according to the overall effect on
the organs:
Sympathetic division = “Fight or Flight”
Parasympathetic division = “Rest and Repair”
Functions of the Nervous System
Collecting information
Peripheral Nervous System
1) Sensory or afferent input
Evaluation and decision making
Central Nervous System
Integration and comparison to:
Homeostatic ranges
Previous or learned experiences
Elicits responses
Peripheral Nervous System
1) Motor or efferent output
General Anatomy of the CNS
Glial Cells
Supporting cells for neurons in the CNS
5 types
1)
2)
3)
4)
5)
Oligodendrocytes = form myelin in the CNS
Schwann Cells = form myelin in the PNS
Microglia Cells = macrophages of the CNS
Ependymal Cells = line cerebral ventricles
Astrocytes = develop neuronal connections
General Anatomy of the CNS
Cranium/Skull
Protects this soft tissue of the brain
Vertebral Column
Protects the spinal cord
Meninges
Connective tissue membranes that separate the
soft tissue of the CNS from surrounding bone
1) Dura Mater
2) Arachnoid mater
3) Pia Mater
General Anatomy of the CNS
Cerebrospinal Fluid (CSF)
Clear, watery fluid that bathes the CNS
Acts as a shock absorber to prevent injury
Provides nutrients to glial cells
Removes waste products
Maintains normal ionic concentrations
surrounding neurons
General Anatomy of the CNS
The CNS requires an abundant blood
supply due to the high metabolic rate of
neuronal tissue
Brain accounts for 20% of all O2 used
Brain accounts for 50% of all glucose used
Blood-Brain Barrier
A physical barrier between the CSF and blood
This semi-permeable membrane functions to
protect the environment surrounding the neurons
in the CNS
General Anatomy of the CNS
Classification of Neurons
Classified according to the direction that the nerve
impulse travels in relation to the central nervous system.
Sensory / Afferent Neurons
Receptors: located in the periphery
1) sensitive to changes inside or outside of the body
Nerve impulses: travel toward the CNS
General Anatomy of the CNS
Interneurons
Also call Association / Internuncial neurons
Function: link between afferent and efferent
neurons
1) Relay information from one part of the CNS to
another for processing, interpreting, and eliciting a
response
Motor / Efferent Neurons
Nerve impulses: travel away from the CNS toward
effector organs
General Anatomy of the CNS
Gray Matter
Areas of the CNS consisting primarily of:
1) Cell bodies
2) Dendrites
3) Axon terminals
Area where synaptic transmission and neural integration
occurs
White Matter
Areas in the CNS consisting primarily of myelinated axons
1) Function to rapidly transmit action potentials over relatively
long distances
The Spinal Cord
Cylinder of nervous tissue
Continuous with the lower portion of the brain
Branches into 31 pairs of spinal nerves
Cervical nerves (C1 – C8)
Thoracic nerves (T1 – T12)
Lumbar nerves (L1 – L5)
Sacral nerves (S1 – S5)
Coccygeal nerve (C0)
The Spinal Cord
Gray matter: concentrated in the butterflyshaped interior region of the spinal cord
Ventral Horn
Contains Efferent Neurons
1) Interneurons
2) Cell bodies
3) Dendrite
Dorsal Horn
Contains Afferent Neurons
1) Axon terminals
The Spinal Cord
Afferent Nerve Fibers
Cell bodies are located outside the spinal cord in
clusters called dorsal root ganglia
These fibers form the dorsal roots
Efferent Nerve Fibers
Cell bodies are located in the spinal cord
These fibers for the ventral roots
The Spinal Cord
Spinal Nerves
Contain both afferent and efferent axons
Joining of the dorsal root and the ventral root
Called Mixed Nerves
Spinal Cord
White Matter: consists of Tracts providing
communication between
1) Different levels of the spinal cord, or
2) The brain and various levels of the spinal cord
Ascending Tracts
Transmit information from the spinal cord to the
brain
Descending Tracts
Transmit information from the brain to the spinal
cord
The Brain
Forebrain
Largest and most superior portion of the brain
Divided into right and left hemispheres
Consists of the Cerebrum and Diencephalon
Cerebellum
Located inferior to the forebrain
Functions include motor coordination, balance, and
feedback systems
Brainstem
Connects the forebrain and cerebellum to the spinal cord
Consists of the Midbrain, Pons, and Medulla Oblongata
The Brain – Cerebrum (Forebrain)
Cerebral Cortex
Thin, highly convoluted layer gray matter
Responsible for conscious initiation of voluntary
movements
Regions of the Cerebral Cortex
Frontal Lobes
Parietal Lobes
Temporal Lobes
Occipital Lobe
The Brain – Cerebrum (Forebrain):
Areas of Specialized Function
Primary Somatosensory Cortex
Involved in processing somatic sensory
information associated with:
1) Somesthetic sensations such as touch, temperature
and pain perception
2) Proprioception which is the awareness of muscle
tension, joint position, and limb position
Primary Motor Cortex
Initiates voluntary movement
The Brain – Cerebrum (Forebrain)
The cerebral cortex is topographically organized
Areas may be mapped according to function
Called somatotopic organization
Motor and Sensory Homunculi
Map of the cerebral cortex corresponding to the part of
the body served by a particular region
The size of the body part on the homunculus is
proportional to the amount of brain dedicated to that body
part
1) For Example, the hand is very large on both the sensory and
motor homunculus because it has many sensory receptors
and requires very fine motor control.
The Brain – Cerebrum (Forebrain)
Subcortical Nuclei
Regions of gray matter within the cerebrum
Includes the Basal Nuclei (Basal Ganglia)
Masses of gray matter scattered deep within the
cerebral hemispheres
Components of the basal nuclei include:
1) The caudate nucleus
2) The putamen
3) The globus pallidus
Important role in modifying movement
The Brain - Basal Nuclei
Normally inhibit motor function thereby
controlling muscle activity
Receive input from:
The entire cerebral cortex
Other subcortical nuclei
1) Such as the subthalamic nucleus of the diencephalon,
substantia nigra, and the red nucleus
No direct connections with the motor
pathways
Send information to the Primary Motor Cortex through the
thalamus
The Brain - Basal Nuclei
Complex role in motor control
Important in starting, stopping, and monitoring
movements executed by the primary motor cortex
It is particularly involved in slow, sustained, or stereotyped
movements
1) Examples: arm swing during gait, riding a bicycle, or eating
Inhibit antagonistic (unnecessary) movements
Enhances the ability to perform several tasks at once
Impairment results in:
Disturbances in muscle tone and posture
Tremors
Abnormally slow movement
The Brain – Diencephalon
(Forebrain)
The diencephalon includes two structures:
1) Thalamus
2) Hypothalamus
Thalamus
Referred to as the “gateway” to the cerebral
cortex
Most afferent neurons synapse with at least
one of the thalamic nuclei
The major relay station for all sensory input
(except smell)
A relay station for impulses that regulate emotion
Also a relay station for motor impulses from the
cerebellum and basal ganglia
Thalamus
Consists of many separate groups of nuclei
Each receiving a certain kind of information
Information is sent from the thalamic nuclei to a
particular region of the cortex
Nuclei of the Thalamus
Ventral Posterolateral Nucleus
Ventral Lateral Nucleus
Medial and Lateral Geniculate Bodies
Thalamus
The Ventral Posterolateral Nucleus
Receives somatic sensory information (touch, pressure, pain)
Relays information to the somatosensory region of the cerebral
cortex
The Ventral Lateral Nucleus
Receives motor information from the basal nuclei and
cerebellum
Relays information to the motor region of the cerebral cortex
The Medial and Lateral Geniculate Bodies
The medial geniculate body sends auditory information from the
auditory receptors to the auditory region of the cerebral cortex
The lateral geniculate body sends visual information to the
occipital region of the cerebral cortex
Hypothalamus
Located inferior to the thalamus and superior to
the brain stem
It is interconnected to the cerebral cortex,
thalamus, and other parts of the brain stem
It consists of a collection of many different
nuclei.
The Supraoptic Nucleus
The Paraventricular Nucleus
The Preoptic Nucleus
The Ventromedial Nucleus
Hypothalamus
The hypothalamus has many roles in regulating
homeostasis
It senses the chemical and thermal qualities of the
blood
It is involved in:
Regulation of heart rate and arterial blood pressure;
Control of movements and glandular secretions of the
stomach and intestines;
Regulation of respiratory rate;
Regulation of water and electrolyte balance; and
Control of hunger and regulation of body weight.
Limbic System
A diverse collection of closely associated cerebral
cortical regions
Encircle the upper part of the brain stem lending is name,
limbus (refers to ring)
The structures of the limbic system include:
The hippocampus
The mammillary bodies of the diencephalon
The hypothalamus
The anterior nucleus of the thalamus
The amygdaloid body
Several gyri and fiber tracts (fornix) that have not yet been
specifically identified
Limbic System
Controls the emotional aspects of behavior
Connected to the cerebral cortex and brain stem
Allows for perception and response to a wide variety of
stimuli
Communicates with the prefrontal lobes to elicit a
relationship between feelings and thoughts.
This explains why emotions sometimes override thoughts
and why reason can override emotion when an emotional
response would be inappropriate.
Part of the system, the hippocampus and the
amygdaloid body are involved in memory
The Brain - Cerebellum
Located inferior to the forebrain and posterior
to the brainstem
Functions:
Coordination of muscular activity
1) Skilled movements, posture, and balance
Regulate muscle tone
The cerebellum has no direct connections
with muscles
It functions at an unconscious level
The Brain - Cerebellum
Receives a variety of information
Information about voluntary muscle activity from the motor
region of the cerebral cortex
Sensory information from proprioceptors throughout the body
Information from the visual and equilibrium pathways
Integrates this information and determines how to
integrate the sensory information with the motor
functions to elicit a coordinated response
Sends its coordination plan to the primary motor cortex
The primary motor cortex then signals the muscles to elicit
the desired response
The Brain - Cerebellum
Cortical Control of Voluntary Movement
Pyramidal Tracts
Direct pathways from the primary motor cortex to the
spinal cord, called Corticospinal tracts
Control small groups of muscles that contract
independently of each other
Extrapyramidal Tracts
Indirect connections between the brain and spinal cord
Includes all motor control pathways outside the pyramidal
system
Control large groups of muscles that contract together to
maintain posture and balance
Pyramidal Tracts
Axons of neurons in these tracts terminate
in the ventral horn of the spinal cord
Called Upper Motor Neurons
Axons of neurons in these tracts cross over
to the opposite side of the CNS in the area
of the medulla
Called Medullary Pyramids
Pyramidal Tracts
Lateral and Ventral Corticospinal Tracts
Carry nerve impulses for skilled, voluntary
contraction of the skeletal muscles
Large motor pathways that descend from
the cerebral motor cortex to the motor
neurons in the ventral horn of the spinal
cord
The largest and most important motor tracts in
the body
Pyramidal Tracts
The Lateral Corticospinal tracts cross over
in the region of the medulla, called the
medullary pyramids
The Ventral Corticospinal tracts cross over
in the spinal cord
Pyramidal Tracts
From the medulla, the corticospinal tracts
descend to the spinal cord level of the muscle
to be innervated
Both lateral and ventral corticospinal tracts synapse
with either:
1) Interneurons, or
2) Motor neurons in the ventral horn of the spinal cord
Interneurons synapse with lower motor
neurons that travel directly to the
neuromuscular junction of the skeletal muscle
the CNS wants to activate
Pyramidal Tracts
The Corticospinal Tracts connect the left cerebral
motor cortex with the muscles on the right side of the
body and vice versa
For example:
The brain has received and processed sensory information that
causes it to direct the biceps muscles to contract to lift a weight
The brain sends impulses down the corticospinal tracts to the
C5-C7 levels of the spinal cord to synapse with the appropriate
motor neurons
The nerve impulse is propogated along the ventral roots of the
brachial plexus, to the musculocutaneous nerve, which
innervates the biceps
The biceps muscle contracts to lift the weight
Extrapyramidal Tracts
Motor control pathways outside of the
pyramidal system
Indirect connections between the brain and
spinal cord
Neurons in these tracts do NOT form
synapses with motor neurons
Include two tracts
Reticulospinal tracts
Rubrospinal tracts
Extrapyramidal Tracts
Reticulospinal Tracts
The Lateral, Anterior, and Medial Reticulospinal tracts
are motor (efferent, descending)
Descend from the reticular formation, which is located in the
pons and medulla
Elicits involuntary motor responses
Functions:
Facilitate extensor motor neurons (promotes muscle tone)
Facilitate visceral motor function, and
Control unskilled movements
Extrapyramidal Tracts
Rubrospinal tracts
Motor (efferent, descending) tracts descending from the
red nucleus (rubro-) of the midbrain
These tracts cross over in the brain stem
Elicits involuntary motor responses
Functions:
Synapse with motor neurons that will transmit impulses to
the neuromuscular junction of the muscle that will contract
Result in muscle contractions that maintain muscle tone in
the flexor muscles on the opposite side of the body
Functional Human Physiology
for the Exercise and Sport Sciences
The Nervous System: Sensory Systems
Jennifer L. Doherty, MS, ATC
Department of Health, Physical Education, and
Recreation
Florida International University
Sensory Receptors
Specialized neuronal structures that detect
a specific form of energy in either the
internal or external environment
Energy is detected by the dendritic end organs of
sensory (afferent) neurons
This information is transmitted to the CNS
Receptors may change one form of energy
to another
For example, chemical to electrical at the NMJ
Types of Sensory Receptors
Chemoreceptors
Sensitive to chemical concentrations such as in smell and taste
Nociceptors or pain receptors
Thermoreceptors
Sensitive to tissue damage
Sensitive to temperature, either to heat or cold
Mechanoreceptors
Sensitive to changes in mechanical energy such as pressure or the
movement of fluids
1)
2)
3)
Baroreceptors detect the blood pressure in certain arteries and veins.
Stretch receptors are sensitive to changes in the amount of inflation in the
lungs.
Proprioceptors are sensitive to changes in tension in the muscles, tendons,
and ligaments.
Photoreceptors
Sensitive to light intensity and are found only in the eyes.
Sensory Transduction
Sensory impulses are generated by receptors
The energy of the stimulus is absorbed
The energy is then transduced into an electrical signal
Receptor potential
A stimulus that exceeds the threshold intensity
Graded potential
The electrical signal that is produced when threshold is
reached
Propagation of a nerve impulse
Sensation
The awareness of a stimulus
Perception
The brain’s interpretation of the sensory information provided by
the sensory receptors
Since all nerve impulses are the same, the only differences
are:
The type of receptor that was stimulated, and
The region of the brain to which the receptor is connected.
For example,
1) When heat receptors in the 2nd finger of the right hand are
stimulated by a lit match, the region of the brain corresponding to
that part of the body will perceive pain
2) If light receptors were transplanted to the region of the brain that
senses smell, then stimulation of the light receptors would result in
an odor being perceived
Sensory Adaptation
Sensory adjustment that occurs when
receptors are continuously stimulated
Sensory Coding
Receptors respond to continuous stimulation by firing at slower
and slower rates
Eventually the receptors may fail to send any signal at all
The sense of smell is particularly subject to sensory
adaptation
For example
When you are in a room with a strong odor you will notice
that soon you cannot smell the odor, or it is much reduced
The smell receptors have adapted and are not stimulated
again until the stimulus changes
Clothing against skin is another example
The Somatosensory System
The Somatosensory Cortex
Postcentral Gyrus of Cerebrum
1) Sensory homunculus
2) Somatic sensory and proprioception
The Somatosensory System
Somatosensory Pathways
Dorsal Column-Medial Lemniscus
1) Transmit sensory impulses from mechanoreceptors and
proprioceptors to the thalamus
2) Crosses over in the region of the medulla
Spinothalamic Tract
1) Transmits sensory impulses from thermoreceptors and
nocioceptors to the thalamus after crossing to the other side
in the spinal cord
2) Crosses over in the spinal cord
Spinothalamic Tracts
The Lateral and Anterior Spinothalamic
Tracts are sensory (afferent, ascending)
Travel from the spinal cord to the thalamus
Receive sensory input from the receptors
for:
Pain (from free nerve endings)
Temperature (from Pacinian corpuscles)
Deep pressure (from Meissners corpuscles)
Touch (from End bulbs of Krause )
Spinothalamic Tracts
Sensory information crosses to the opposite
side in the spinal cord
The sensory information ascends to the
thalamus
A synapse occurs with one of the thalamic nuclei
The sensory information is sent from the
thalamus to sensory cortex of the cerebrum
Located in the post central gyrus
For example:
A heat receptor (free nerve ending) located in the L3
dermatome on the anterior thigh is stimulated by the heating
pad you have put on the quadriceps muscle group of your sore
right thigh
The impulse travels along the peripheral nerve through the
sensory neuron in the dorsal root ganglion and on to a synapse
with an internuncial neuron in the dorsal horn of segment L3
From there the fiber carrying the next impulse crosses over to
the left side of the spinal cord to the lateral spinothalamic tract,
and ascends to the thalamus.
Another synapse occurs in the thalamus and the next impulse is
sent to the sensory cortex of the cerebrum where the brain will
perform its integrative and decision making functions.
A decision will be made whether to instruct the muscles of your
hands and arms to remove the heating pad because it is too hot
or leave it in place.
Pain Perception
Mediated primarily through free nerve endings
Sensitive to a variety of painful or noxious stimuli
Changes in chemical composition of body fluids,
such as decreased pH or accumulation of
metabolic wastes can stimulate pain receptors.
Adaptation to pain is practically non-existent
Pain sensation can be triggered by a single stimulus and
is longer lasting than many other types of stimuli, such as
hot, cold, or smell
Pain Pathways
Pain impulses are transmitted through the ascending pathways
of the spinal cord, primarily the lateral spinothalamic tracts to
the brain
Nocioceptors (pain receptors) located in the skin
When stimulated, send pain information along a first order
neuron
First order neurons
Deliver sensory impulses from the receptor to the dorsal horn of
the spinal cord where it synapses on a second order neuron
Second order neruons
Travel in the spinothalamic tract to the thalamus which relays
the information to the appropriate area of the primary
somatosensory cortex
Pain Pathways
Within the brain most of the pain sensation
terminates in the reticular formation and are
processed by the thalamus, hypothalamus
and the cerebral cortex
The brain, after evaluating the extent of the
pain, sends information back along a
designated motor tract to the muscles that
require contraction to move the limb away
from the source of pain
Visceral Pain
Usually not very well localized
It may feel as though it is coming from another part of the body
than from the organ actually affected
Referred pain
Results from common nerve pathways that bring sensory
information from skin or muscles of another part of the body in
addition to that of an organ.
For Example,
Pain impulses from the heart are conducted along the same
neural pathways as pain from the left arm and shoulder
Thus, the brain interprets heart pain as the more familiar
shoulder and arm pain
Modulation of Pain Signals
In cases of extreme pain, impulses are capable of
stimulating the release of biochemicals that can
block pain impulses
Among these biochemicals are:
Neuropeptides
Serotonin
Enkephalin
Endorphins
These biochemicals can bind to pain receptors and
block the sensation of severe or acute pain
The Nervous System:
Autonomic and Motor Systems
Jennifer L. Doherty, MS, ATC
Department of Health, Physical Education, and
Recreation
Florida International University
The Autonomic Nervous System
Peripheral Nervous System
Somatic NS
Autonomic NS
1) Sympathetic
2) Parasympathetic
The involuntary part of the PNS
Operates without conscious control
Primary function is to maintain homeostasis
The Autonomic Nervous System
Controls the following:
Smooth muscle of the blood vessels;
Abdominal and thoracic viscera;
Certain glands; and
Cardiac muscle.
Serves an important role in maintaining:
Heart rate
Blood pressure
Breathing
Body temperature
The Autonomic Nervous System
Dual Innervation of the ANS
The sympathetic division of the ANS is
responsible for readying the body for
strenuous physical activity or emotional
stress
Fight or Flight Response
Prepares the body to deal with disturbances
to homeostasis (threatening situations)
Anatomy of the ANS
The ANS consists of efferent pathways
Each efferent pathway contains 2 neurons
that are arranged in series to each other
Provides communication between the CNS
and the effector organ
Anatomy of the ANS
Autonomic Ganglia
Provide communication pathways via synapses between
neurons
Preganglionic Neurons
Travel from the CNS to the ganglia
1) Sympathetic chain ganglion,
2) Collateral ganglion, or
3) Parasympathetic ganglion
Postganglionic Neurons
1) Neurons that travel from the ganglion to the effector
organ
Sympathetic Nervous System
Thoracolumbar Division
Preganglionic Neurons
Arises from the ventral roots of all thoracic spinal nerves
Arises from the ventral roots of lumbar spinal nerves 1-3
Originate in the Lateral Horn of the spinal cord
Cell bodies are located in the thoracic and upper lumbar regions
of the spinal cord
Short Myelinated Axons
Postganglionic Neurons
Synpase with preganglionic neurons in the Sympathetic
Chains (Trunks)
Long Unmyelinated Axons
Sympathetic Nervous System
Sympathetic Chains (Trunks)
Where preganglionic and postganglionic neurons
synapse in the Sympathetic NS
Comprised of sympathetic nerves that are
connected to a string of nerve cell bodies
Called the Sympathetic (Paravertebral) Chain
Ganglia
These interconnected ganglia are located close
to the spinal cord
Far away from the structures it innervates
Parasympathetic Nervous System
Craniosacral Division
Preganglionic Neurons
Arises from the cranial nerve nuclei in the brain stem
Arises from the ventral roots of sacral spinal cord
Those originating in the cranial nerve nuclei travel with axons of
cranial nerves and terminate in ganglia near the effector organ
Those originating in the sacral spinal cord synapse with other
parasympathetic preganglionic neurons to form pelvic nerves
that terminate near the effector organ
Long Myelinated Axons
Postganglionic Neurons
Travel to the effector organ
Short Unmyelinated Axons
Mixed Composition of ANS Nerves
Both systems function utilizing two neurons that
communicate through a ganglion
Preganglionic nerve fibers arise in the CNS
Myelinated axon leaves the CNS as part of a cranial
nerve or spinal nerve
Travels to an autonomic nervous system ganglion
Preganglionic nerve fibers synapse with the
postganglionic nerve fibers in the ganglion
Postganglionic nerve fibers travel to the
appropriate effector organ
Effects of the ANS
The two divisions have opposite effects
on the organs and structures innervated
Sympathetic Nervous System
Acetylcholine = neurotransmitter at the synapse
with the ganglion
Norepinephrine = neurotransmitter at the
synapse with the effector organ
Parasympathetic Nervous System
Acetylcholine = neurotransmitter at both
synapses
Effects of the ANS
Cholinergic Neurons
Adrenergic Neurons
Release Acetylcholine
Cholinergic Receptors
Nicotinic receptors
1) Excitatory
2) Opens Na+ and K+
channels
Muscarinic receptors
1) Excitatory or Inhibitory
2) Uses G-proteins to open
specific ion channels
Release
Norepinephrine
Adrenergic Receptors
Alpha receptors
1) Excitatory
Beta receptors
1) Excitatory or Inhibitory
Effects of the ANS
The sympathetic division generally
produces a whole body response when
stimulated.
The overall function of the sympathetic division is
the fight or flight response.
The parasympathetic division generally
produces a single response at a specific
effector organ.
The overall function of the parasympathetic
division is rest and repair.
Comparison: Somatic and Autonomic
Nervous Systems