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Using Davis to Compare Neural Models CAJAL NEUROSCIENCE RESEARCH CENTER The University of Texas at San Antonio E. Pilipaviciute1, K. A. Robbins1,3, D. M. Senseman2,3 1Department of Computer Science 2Department of Biology 3Cajal Neuroscience Research Center University of Texas at San Antonio, San Antonio, TX 78249 Direct view comparison Davis (Data Viewing System) is a general-purpose data viewer designed for the simultaneous display and comparison of dynamic data sets. Inspired by the need to explore data from imaging experiments and large computational models of the cerebral cortex, Davis allows scientists to study the detailed behavior of individual elements and the interaction of these elements to achieve cortical function. Davis provides direct views that animate activity over time. Davis also supports parallel coordinate latency visualizations, remapped space-time activity diagrams, and low dimensionalprojections of correlated behavior that facilitate comparison of structure across data sets. We demonstrate Davis by comparing two versions of the NGU. Space-time activity diagrams Modified model Stellate time line at 0.341 seconds Modified model Original model GabaA Soma voltage 122 Modified model AMPA Original model Modified model 122 Original model in gray with magenta dot, modified model in black with red dot, t = 150 ms. Conclusions NGU model of turtle visual cortex Parallel coordinate latency view time line at 0.444 seconds Half-height latency ordering for lateral voltage (original versus modified) Original model Original model Modified model NMDA Original model Medial AMPA Original model Davis interface is built automatically from user XML files The NGU model [2] has 4 types of neurons (lateral, medial, horizontal and stellate neurons). LGN HH neurons deliver the input. A modified NGU model adds inhibitory subpial neurons [3]. The models are run under Genesis [1] using diffuse flash stimuli. Lateral Soma Voltage Soma voltage Original model Low-dimensional projections NMDA Introduction Modified model Davis is a freely available data viewer that supports multiple simultaneous views of data with spatial and temporal dependencies. We illustrate the use of Davis here by comparing two models of the turtle visual cortex. Shown are direct views, parallel coordinate views of orderings, space time activity diagrams with overlays and KL caricatures [4, 5, 6]. The Davis website is http://vip.cs.utsa.edu/research/Davis/index.html. Acknowledgements Modified model Neurons: Excitatory: Inhibitory: Lateral Horizontal Medial Stellate LGN Subpial Lateral neurons Medial neurons GabaA We are grateful to our collaborators on the turtle brain project, Philip Ulinski and Bijoy Ghosh, for sharing their models and insight. This work was partially supported by NIH (G12 RR13646) and NSF EIA-0217884, NSF-NIH collaborative research in neuroscience. References [1] J. M. Bower and D. Beeman, The Book of Genesis: Exploring Realistic Neural Models with the General Neural Simulation System, 2nd Ed, Springer-Verlag, 1998. [2] Z. Nenadic, B. Ghosh, and P. Ulinski, Propagating waves in visual cortex: A large-scale model of turtle visual cortex, J. of Computational Neuroscience, 14(2):161-184, 2003. [3] W. Wang, B. Ghosh, and P. Ulinksi, Integrative physiology of subpial cells, submitted. [4] K. Robbins, M. Robinson and D. Senseman, Visualizing cortical waves and timing from data, IEEE Visualization ‘2004, 401-408, 2004. [5] K. Robbins and D. Senseman, Extracting wave structure from biological data with application to responses in turtle visual cortex, J. Computational Neuroscience, 16:267-298, 2004. [6] K. Robbins, I. Grinshpan, K. Allen and D. Senseman, Synchronized views for exploring populations of neurons, Proc. SPIE (Papers selected from Visualization and Data Analysis 2004, Eds R. F. Erbacher, P. C. Chen, J. C. Roberts, M. T. Gröhn, K. Börner), 5295:235-245, 2004. time line at 0.074 seconds