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Considering Honours in the Neuroendocrinology Research Group? The Neuroendocrinology Research Group provides a diverse range of projects embracing three main areas of research The Tilbrook Lab. Impact of Stress on Physiological Systems (click here) The Nichols’ Lab. Endocrine Control of Adult Neurogenesis (click here) The Clarke Lab. Regulation of Reproduction (click here) Contact us IMPACT OF STRESS ON PHYSIOLOGICAL SYSTEMS Reproduction Sex How does stress impact on fertility? Why do males and females have different incidences of stress-related diseases? How does reproductive experience affect learning and memory in the face of a stressor? Home Contact us Visceral Fat Does being lean make you less responsive to stress? Does being obese from an early age make you more susceptible to disease? Endocrine Control of Adult Neurogenesis • The Nichols’ lab is interested in regulation of adult neural stem cells by hormones and growth factors or cytokines • We use both in vivo (upper panel – brown cluster of proliferating nuclei) and in vitro approaches (lower panel – blue nuclei, red neurons, green glia) to study how neural stem cells develop into functional neurons • We are particularly interested in effects of stress and stress hormones (glucocorticoids) on neurogenesis during brain repair Home Contact us Regulation of Reproduction Professor Iain Clarke has built an internationally recognized group that has remained consistently competitive in the field of neuroendocrinology and brain mechanisms relevant to the control of reproduction. Most recently, his laboratory has made a major impact in the field of kisspeptin and their imperative role in regulating the GnRH system. Expression of KiSS-1 mRNA in the Arcuate Nucleus of the ewe. Detected by in situ hybridisation. Projects Available • Activation of the GnRH system by melanocortin agonists. • Processing of POMC peptides in the arcuate nucleus in different physiological states and the effects of leptin. • Role of Kisspeptin in the regulation of the GnRH system. • Effect of environmental pollutants and endocrine disruptors on the neuroendocrine systems. Immunohistochemisrty of Kisspeptin neurons (green cells) co-expressing Progesterone Receptor (red cells) in the Arcuate Nucleus. Home Contact us Contact Us Ass. Professor Alan Tilbrook Department of Physiology Building 13F Room F248, Clayton Campus Email: [email protected] Back to Alan’s lab. Dr Nancy Nichols Department of Physiology Building 13F Room F243, Clayton Campus Email: [email protected] Back to Nancy’s lab. Sheep Brain Image: http://www.msu.edu/user/brains/sheepatlas/index.html Supported by the U. S. National Science Foundation Professor Iain Clarke Department of Physiology Building 13F Room F228, Clayton Campus Email: [email protected] Back to Iain’s lab. Home Exit