Gas Exchange and Smoking
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Transcript Gas Exchange and Smoking
Part 2
Non- Infectious
Diseases :
• Cardiovascular disease
• Lung Disease (COPD,
bronchitis,
emphysema)
• Cancer
NON-COMMUNICABLE!!!!
•
•
•
•
Infectious Diseases
caused by Pathogens:
Tuberculosis (bacteria)
Cholera (bacteria)
Malaria (protista)
HIV (virus)
COMMUNICABLE!!!!
Sign
Visible
expression of a
disease
Doctor can see
these through
examination or
testing
Ex.
Sign vs. Symptom Cannot be
Symptom
High
temperature
Rash
detected by
examination
Things a patient
feels but a doctor
cannot detect
Must be reported
by patient
Ex.
Headache
Dizziness
Smoking and Lung
Disease
Smoke contains substances that effect
Gas Exchange System and
Cardiovascular System
Small particles less than 2 um can
reach the alveoli
Filter system of respiratory system is
much slower in bronchioles
particles settle in alveoli settling of
particles leads to influenza,
pneumonia, allergies, asthma
Mainstream vs. side stream smoke
MS from filter end
SS more toxic to resp. system
Tar
• Mixture of
many
chemical
substances
• Carcinogens
Nicotine
• Additive
• Absorbed readily by blood and
travels quickly to brain
• Effects Nervous System
• binds to receptors on neurons in
brain
• Increase release of DOPAMINE
(pleasure
neurotransmitter=addiction)
• Effects Circulatory System
• Increases release of ADRENALINE in
blood stimulate DECREASE in
diameter of arteries
(VASOCONSTRICTION)= increase
in HR, BP, and BR = decrease in
blood supply to extremities
• Increase likelihood of blood clots
forming
Carbon Monoxide
• Combine
irreversibly with
haemoglobin
(carboxyhaemoglob
in) = decrease
amount of
haemoglobin
available for oxygen
to attach to =
decrease in
oxygen available
to tissues
• Damages lining of
arteries
Effects of Smoking
Gas Exchange System
Chronic Obstructive Pulmonary Disease (COPD)
Chronic Bronchitis
Emphysema
Lung Cancer
Cardiovascular System
Atherosclerosis
Coronary Heart Disease (CHD)
Carcinogens in Tobacco
Nicotine
Tar
carbon monoxide
Ammonia
Formaldehyde
Phenols
Creosote
Anthracene
Pyrene
hydrocyanic acid
Arsenic
lead
Tar
particulate matter derived from burning organic
compounds
Chronic Obstructive Pulmonary
Disease COPD
Chronic
bronchitis and
emphysema
Extremely
disabling
Causes:
Pollution
(indoor/outdo
or)
Smoking
(chemicals is
smoke)
Narrowing of Air Passageways
Bad!
2 main causes:
1. Inflammation
Immune response (inflammatory response)
Due to infection in respiratory tissue (from
bacteria/particles/pathogens in slow moving mucus)
2. Build up of scar tissue and smooth muscle
mucus sitting in passageways not being moved
causes constant cough causes damage to epithelium
need for more smooth muscle and build up of scar
tissue = narrowed lumen
Chronic Bronchitis
Increased mucus secretion
Goblet cells
Enlarged mucus glands
Ciliated epithelium weakened or
destroyed
Ciliated epithelial cells beat LESS
efficiently (cannot effectively move
mucus out)
Mucus contains dust particles;
become infected with
bacteria/viruses
Stimulates cough = damage to
airway tissue = airway stiffens and
narrows
Build up of mucus blocks
alveoli difficulty in gas exchange
(diffusion distance b/t air in alveoli
and blood in capillaries is greater)
Emphysema
Smoking causes Inflammation of lungs
Infection in lungs = inflammation = narrow
airways
Increase in WBC (phagocytes) in lung tissue
WBC leave blood and line airways
Secret enzyme ELASTASE to they can break
up elastic (elastin) fibers surrounding alveoli
and reach surface of alveoli to destroy bacteria
No more elastin = no stretching/relaxing of
alveoli when breathing
Bronchioles collapse during exhalation
Trap air in alveoli burst; larger air spaces
Decrease SA for gas exchange
Decrease # of capillaries
Blood vessels in lungs become resistant to blood
flow pressure in pulmonary artery
INCREASES to compensate for this
increase in size of RIGHT side of heart
Decrease oxygen absorbed in blood
Symptoms shortness of breath, wheezing
60 million people world wide effected
Asthma
Lung Cancer
Caused by carcinogens in TAR
Cause mutations to DNA
Effects genes that control cell division
Especially with epithelial cells of
respiratory tissue
DNA damage tumor formation
Forms in lungs AND other parts of gas
exchange system
Spreads from bronchial epithelium
lymphatic tissue metastasis
Secondary tumors form elsewhere
(malignant)
Symptoms: chest pain, fatigue and
weight loss
Lung Cancer
Methods to locate
Bronchoscopy
Chest x-ray
CT scan
Treatment
Surgery
Radiotherapy
chemotherapy
Cholesterol
Important in:
--cell membranes
--Vitamin D synthesis in skin
-Hormone synthesis in ovaries,
testes, adrenal gland
LDL
Low Density Lipoprotein
Transport cholesterol from
liver to tissues and artery
walls
Deposits cholesterol at
damaged site
HDL
High Density Lipoprotein
Removes cholesterol from
tissues
Transports cholesterol to
liver to be excreted
Protection against
atherosclerosis
Atherosclerosis
Definition: thickening and loss of
elasticity in walls of arteries
Caused by build up of plaque in blood
vessel walls
Plaque: rough patch of cholesterol rich
atheroma on artery walls
Reduces elasticity AND restricts blood
flow
Atheroma: fatty material containing
Platelets, Dead muscle cells, Cholesterol,
Fibers
Atheromatous streaks
Yellow streaks in artery caused by tobacco
smoke or High BP
Phagocytes rush to damaged area secrete
proteins to stimulate growth of smooth
muscle cells to repair damage
Cholesterol accumulate in area
Atherosclerosis
Effects of Plaque on artery wall
Growth pushes inwards towards lumen,
reducing blood flow
Ruptures through lining of artery creating
rough surface lining artery that stimulates
formation of clots forms THROMBUS
(clot )
THROMBOSIS formation of thrombus
that interrupts blood flow
Tissues starved of oxygen and nutrients
Especially dangerous in coronary artery
heart attack
Especially dangerous in brain stroke
Nicotine and CO increase risk of
developing atherosclerosis
Stroke
2 major causes
1. Artery in brain bursts and
blood leaks into brain tissue
(brain hemorrhage)
2. Blockage in brain artery due to
atherosclerosis or thrombosis
Cerebral Infraction
When brain tissue is starved of
oxygen and dies
Different degrees of severity
Different areas effected
Coronary Heart Disease CHD
Definition: atherosclerosis in coronary artery that supplies
heart muscle with oxygenated blood
Arteries narrow, heart has to beat harder to get blood to itself
increase in blood pressure
Harder for heart to get oxygen and nutrients it needs, esp. during
exercise
Three types
1. Angina pectoris
Symptom: severe chest pain during exertion
Caused by severe shortage of blood to heart muscle
No death of heart tissue
Heart Attack (myocardial infraction)
2.
When large branch of CA is obstructed by clot
Part of heart muscle starved of oxygen and dies
Symptoms: sudden and severe chest pain
Fatal unless treated immediately
Heart Failure
3.
Caused by blockage to major coronary artery
Gradual damage to heart muscle
Heart weakens and fails to pump effectively
Evidence for Effects of Smoking on Health
Epidemiological Evidence
Consists of data collected about people’s smoking habits and their
health
Large #s of people should be involved
Look for correlations b/t smoking and particular disease
Shows that there COULD be a causal relationship between smoking and a
disease (not definite)…ASSOCIATION
Must gather physiological evidence to state definite relationship
Experimental Evidence
Consists of carrying out experiments
1960s experiments with dogs and other animals
IV: whether person smokes of not (or how much they smoke)
DV: aspect of physiology
All other variables kept constant
Unethical in humans
Conclusion: smoking increases risk of developing cancer
More ethical experiments now
Carried out with lungs tissue cells grown in culture exposed to various cigarette
chemicals
Preventing and Treating
CHDs
Prevention
Lifestyle choices that reduce risk
factors
Screening
Factors that Increase Risk of CHD
Inheriting particular alleles of genes
Eating a diet high in saturated fats
and cholesterol
No exercise
Obesity
smoking
Treating CHD
Medication
Lower BP
Decrease clotting
Prevent abnormal heart rhythms
Reduce retention of fluid in blood
Decrease cholestreol concentration in blood
Coronary bypass
Piece of blood vessel is taken from another part of body and sewn in
place as alternate route for oxygen to flow from aorta to heart
muscle
Heart transplant
Must be heart from person who has just dies
Similar tissue type
Patient needs to take immunosuppressant drugs for rest of life to prevent
rejection
Know sequential events and link to
BIG picture!
Damage to endothelial lining caused by changing/high blood pressure
(nicotine) and by damaging chemical components (smoking) cause
plaque formation
Exposure of fibrous and smooth muscle tissue leading to increase in
tissue (may protrude into lumen)
Platelet damage and clot formation (nicotine effect plus non-smooth
lining causing turbulent blood flow)—thrombosis
Cholesterol deposition and macrophage attraction to damaged areaatheroma/atheromatous streaking
Overtime, calcium deposition (causes hardening and loss of elasticity)—
atherosclerosis (arteriosclerosis)
Above effects causing narrowing in lumen of coronary artery, reducing
blood flow to cardiac muscle = insufficient oxygen and glucose(angia,
heart attack)
Above effects in coronary artery = Coronary Heart Disease (CHD)
Above effects in arteries serving brain that lead to reduced blood supply
(thrombosis or aneurysm) = strokes