Transcript Blank Jeopardy

DEFINITIONS
NAME THAT
ANTIGEN
DISEASE
ASSOCIATION
KELL
SYSTEM
ENZYMES
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This is the ability of an antigen
to stimulate an antibody
response.
Immunogenicity
This is the term for
antigens that are present in
less than 10% of the
general population.
Low prevalence
Low frequency
Low incidence
Familial
Private
DAILY DOUBLE
This is a known failure of an
antigen-antibody reaction to
yield a positive test result as a
consequence of antibody excess.
Prozone
This is the term for a
reaction in which one cell
population is agglutinated,
but a second cell
population remains free.
Mixed-field
What term has been used to
denote those antibodies
which react weakly both
when diluted or undiluted,
but are present in high
concentration.
HTLA
(High Titer, Low Avidity)
After the ABO and Rh
antigens, this antigen is the
most immunogenic.
Kell
Name an antigen in the Kell
system that is high prevalence.
k (Cellano)
Kpb ( Rautenberg)
Jsb (Matthews)
This antigen is formed by a
non-secretor who has
inherited the genes lele.
c
Le
Anti-Tja is associated with this
blood group system.
P
Name one antigen that is part of
the C4 molecule of complement,
and therefore not an intrinsic
part of the RBC membrane.
(An example of an HTLA antibody)
Chido or Rodgers
This relatively uncommon
antibody is found in up to 80% of
patients with infectious
mononucleosis.
Anti-i
This antigen, related to the Kell
system, is associated with
Chronic Granulomatous
Disease.
Kx
The erythrocytes of
individuals with this
phenotype appear to resist
invasion by
Plasmodium vivax.
Fy (a-b-)
The Donath-Landsteiner
antibody that is present in the
serum of patients with
paroxysmal cold
hemoglobinuria (PCH) has this
specificity.
Anti-P
A patient with a Mycoplasma
pneumoniae infection will most
likely develop a cold
autoantibody with this specificity.
Anti-I
Antibodies of the Kell system
generally react at this phase of
testing.
AHG
Give two reasons a patient
who had anti-K two years ago
now appears to be compatible
with two random donor units
of red blood cells.
1.Both units are K negative.
2.The anti-K titer is too low
to be detected.
Name three pairs of antithetical
antigens at the Kell locus.
1.K and k (Kell and Cellano)
2.Kpa and Kpb (Penny and
Rautenberg)
3.Jsa and Jsb (Sutter and
Matthews)
Individuals of the Kell null
phenotype may only be
transfused with RBCs from
other Kell null individuals
because their plasma contains
this antibody.
Anti-Ku
A person with anti-K will be
compatible with approximately
this many random donors out of
ten.
9
This enzyme is the most
commonly used in routine Blood
Banking.
Ficin
Papain is derived from this
plant.
Papaya
Name 5 blood group antigens that
are enhanced by enzymes.
Kidd, Lewis , Rh, Ii, P,
ABO
(Kidd Lewis has Ripples
In his Pecs and Abs.)
DAILY DOUBLE
Name 5 blood group antigens that
are adversely affected by
proteolytic substances.
MNS, Fy,
a
Xg
(Many New Soldiers are destroyed
in the Field by eXplosions.)
Note: Sometimes Kell (Many New
Soldiers are Killed in the Field by
eXplosions)
These antigens of the
Duffy system are enzyme
resistant.
Fy3, Fy5 (and Fy4)