Dengue fever - Farmasi Unand
Download
Report
Transcript Dengue fever - Farmasi Unand
Dengue fever
Dengue fever
Pengertian dengue fever
Dengue (DF) and dengue hemorrhagic fever
(DHF) are caused by one of four closely related,
but antigenically distinct, virus serotypes (DEN1, DEN-2, DEN-3, and DEN-4), of the genus
Flavivirus.
Infection with one of these serotypes provides
immunity to only that serotype for life, so
persons living in a dengue-endemic area can
have more than one dengue infection during
their lifetime.
DF
and DHF are primarily diseases of
tropical and sub tropical areas, and the
four different dengue serotypes are
maintained in a cycle that involves
humans and the Aedes mosquito.
However, Aedes aegypti, a domestic, day-biting
mosquito that prefers to feed on humans, is the
most common Aedes species.
Infections produce a spectrum of clinical illness
ranging from a nonspecific viral syndrome to
severe and fatal hemorrhagic disease.
Important risk factors for DHF include the strain
of the infecting virus, as well as the age, and
especially the prior dengue infection history of
the patient.
No
dengue vaccine is available.
Beberapa pengertian
Endemic - means a disease occurs continuously
and with predictable regularity in a specific area
or population .
Epidemic - a widespread outbreak of an
infectious disease where many people are
infected at the same time.
Outbreak - an epidemic limited to localized
increase in the incidence of a disease, e.g., in a
village, town, or closed institution
Pandemic - an epidemic occurring worldwide, or
over a very wide area, crossing international
boundaries, and usually affecting a large number
of people.
Recombinant vaccine - using the technique of
recombination to create an attenuated virus
which elicits an immune response against the
viral strain of interest in order to use as a
vaccine in humans.
Seroytpe - a closely related set of viruses that
can be differiented by the immune response they
produce.
Viral envelope gene sequence - the nucleic acid
composition in the envelope gene