Transcript Rheumatoid arthritis - Sveučilište u Zagrebu Medicinski

Rheumatoid arthritis
Tena Trbojević
Mentor: A. Žmegač Horvat
Rheumatoid arthritis
chronic diesease
inflammatory disease
(inflammation of joint
lining)
autoimmune disease
(immune reaction against
joint tissues - synovial
membrane)
Rheumatoid arthritis
causes pain,
swelling, stiffness,
loss of function in
the joints
generally occurs in
a symmetrical
pattern
may also attack
tissue in the skin,
lungs, eyes, and
blood vessels
Rheumatoid arthritis
small joints of hands and feet
affected first, larger joints later
Rheumatoid arthritis
begins
during the
most
productive
years (30 –
60)
occurs much
more
frequently in
women than
in men
(w:m=3:1)
Rheumatoid arthritis
specific agent or agents are not
yet known
infectious agents, such as
viruses and bacteria, may
trigger RA in people with an
inherited tendency to develop
the disease
Rheumatoid arthritis
synovitis
fibrous ankylosis
bony ankylosis
osteoporosis
Rheumatoid arthritis
Rheumatoid arthritis - symptoms:
Around the joints
warmth
redness
swelling
pain
limitations in joint
motion
General
sickness
tiredness
fever
Rheumatoid arthritis
can be difficult to diagnose in its early stages
Patient history
- questions about the intensity of pain symptoms
- frequency of symptoms
- what makes the pain better or worse
RTG, MRI, arthrography, arthroscopy
Blood test (RF, CRP, SE)
RF→ Waaler- Rose test
1:32=normal
1:64≤ pathological
Rheumatoid arthritis
Treatments can:
relieve pain
reduce swelling
slow down or help
prevent joint damage
increase ability to
function
improve sense of wellbeing
Rheumatoid arthritis – treatment
options:
exercise
medication
stress reduction
DMARDs (disease-modifying antirheumatic drugs): methotrexate,
leflunomide, sulfasalazine,
cyclosporine
corticosteroids : cortisone,
hydrocortisone, prednisone
in some cases - surgery (joint
replacement and tendon reconstruction
- two types of surgery available to
patients with severe joint damage )
Rheumatoid arthritis
research efforts: focused on developing
drugs that can reduce inflammation and
slow or stop the disease with few side
effects; investigators trying to identify
the infectious agents and understand
how they work → new therapies
scientists are also examining why
rheumatoid arthritis often improves
during pregnancy
Rheumatoid arthritis
http://www.medicinenet.com/rheumatoid_arthritis_pictures_slideshow/
article.htm
http://video.about.com/arthritis/Chronic-Rheumatism-Hand.htm
http://nihseniorhealth.gov/videolist.html#rheumatoidarthritis
References:
http://nihseniorhealth.gov/videolist.html#rheumatoidarthritis
http://www.medicinenet.com/rheumatoid_arthritis_pictures_sl
ideshow/article.htm
http://video.about.com/arthritis/Chronic-RheumatismHand.htm