Transcript ppt - Clayton Foundation for Research

Alexandra Richardson, PhD, CLP
April 2015
Clayton Biotechnologies, Inc. is a for-profit company which facilitates
the commercialization of medical discoveries made by the Clayton
Foundation for Research and its supporting entities.
The Clayton Foundation for Research is a nonprofit medical
research organization in Houston, Texas established in 1933 by
Benjamin Clayton.
The two-fold mission of the Foundation is to:
► conduct medical research for the purpose of discovering the cause,
prevention and cure of diseases for the benefit of mankind, and
► transfer the resulting medical research discoveries from the laboratory to
the use of the general public by patenting and licensing such technology
for development into drugs or other products.
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Medical Research at Leading Research Institutions
U. of Geneva
North Carolina State
UCSD
Salk
UT-Austin
UT-Southwestern
MD Anderson
UTHSC-San Antonio
Baylor College of Medicine
UT-Medical Branch
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Medical research for the
purpose of discovering the
cause, prevention and cure
of diseases for the benefit of
mankind
Medical Research to Develop Cures
Cancer
Immunotoxins for targeted cancer therapy
CNS &
Ophthalmology
Stem Cell Therapy for Parkinson’s Disease
Metabolic Diseases
Urocortin peptides for diabetes
Avicin to treat Mantle cell Lymphoma
Monoclonal antibodies targeting angiogenesis
Engineered proteases
Modulation of brain stress in neurological
diseases
GLP-1 combination therapy
Genetic disease models for neurological diseases
Molecular switches in glucose control
Gene therapy and peptide therapeutics for AMD
Serum oxysterols as biomarkers of disease
Next generation anti-mitotic drugs
Fc engineered aglycosylated antibodies
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Medical Research to Develop Cures
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Infectious
Diseases
Autoimmune &
Inflammation
Cardiology
Endometriosis
Vaccines for Dengue and
Chinkungunya
Engineered proteases
Urocortin peptides and
gene therapy for congestive
heart failure
Small molecules targeting
SRC
Vaccines and diagnostics
for Ehrlichioses
Fc engineering of
aglycosylated antibodies
OCT-TPL diagnostics of
human vascular plaques
OCT Image Guided Laser
knife for diagnosis and
treatment
Leaders in Innovation and Technology
Stem Cell
Therapy
Examples
Gene
Therapy
Neuropeptides
Protein Engineering,
Antibodies and
Immunotoxins
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Transforming Research Into Products
Mission Two:
To transfer the resulting medical research discoveries from the
laboratory to the use of the general public by patenting and licensing
such technology for development into drugs or other products.
• Collaborations
• Spin-out companies
• Licensing
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Portfolio of Start-up Companies
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Some of Our Other Licensees
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Marketed Products
Exparel
DepoDur
• Morphine liposome injectable suspension
• Post-operative pain
Depocyt
• Cytarabine liposomes injectable suspension
• Lymphomatous and solid tumor meningitis
Attrius
Retcam
AccuPlex 4
SCA6 Diagnostic tests
FIA
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• bupivacaine liposome injectable suspension
• Pain
• Cardiac PET Imaging
• Medical imaging systems for private practices
• Neonatal and pediatric imaging system
• Wide-field digital imaging system for the hospital and clinic
• Ehrlichoisis canine
• Assay for canine vector borne diseases
• Ataxia diagnostic
• Assay for Spinocerebellar ataxia type 6 (SCA6)
• Functional Intracellular analysis
• Assay for intracellular function of essential micronutrients
Clinical Pipeline
Candidate
compound
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Indication
Partner
Development Stage
Lenti-D
Childhood
ALD
Pre-clinical
Phase I
LentiGlobin
Betathalassemia
Pre-clinical
Phase I/II
LentiGlobin
Sickle cell
anemia
Pre-clinical
Phase I
Retinostat
AMD
Pre-clinical
Phase I
Urocortin
Congestive
Heart Failure
Pre-clinical
Phase I
VC-01
Type I
Diabetes
Pre-clinical
Phase I
a-TEA
Breast cancer
Pre-clinical
Phase I
Phase II/III
Phase II
Available to Partner
A Cancer Research Hospital
Advanced Pre-clinical Pipeline
Candidate
compound
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Indication
Development Stage
Encorstat
Corneal
graft
rejection
Pre-clinical
Avicin
Mantle Cell
Lymphoma
Pre-clinical
Dengue
tetra vaccine
Dengue
Fever
IND package
VEGF-rGel
Solid
Tumors
IND package
VEGF-rGel
AMD
Partner
IND
IND
Available to Partner
Advanced
pre-clinical
Available to Partner
Collaboration and Licensing Opportunities
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Urocortins and analogues for Diabetes
GLP-1 agonist combination therapies for Diabetes
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Alk4-Fc, a Cripto antagonist for Cancer
Granzyme B - a potent payload for antibody drug conjugates (ADC)
YESS - engineering of proteases
Fc engineered antibodies with specific effector function
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Filaggrin to treat dermatological disorders
TEAD gene and peptide therapies for ocular neovascular disease
CRFR1 antagonists - therapeutic for early onset AD
Stem cell therapy program for Parkinson's Disease
Vaccines and Diagnostics for Ehrlichioses
OCT guided laser knife for surgery in small spaces
Conducting and funding research
Transferring research into products
One Riverway, Suite 1520
Houston, Texas 77056
713.963.5860
www.claytonbiotech.com
[email protected]