Human African Trypanosomiasis

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Transcript Human African Trypanosomiasis

Human African
b
Trypanosomiasis
Human African Trypanosomiasis (HAT)
is commonly known as sleeping sickness
HAT proceeds rapidly from lethargy
through coma to death
HAT is caused by a parastic protozoan
HAT is spread by the tsetse fly
or through contaminated blood
Life Cycle
There are two Types of HAT
• Trypanosoma brucei
rhodesiense
• Trypanosomoa brucei
gambiense
• Acute -- can cause
death in weeks or
months
• Chronic --lasts years
The two types
of HAT affect
different parts
of Africa
The major risk Factor I, once again…
exposure to these little bugs!
100%
Fatal if left untreated
cardiac failure or from the infection itself
Past epidemics have left their mark on
Africa.
Blood Smears can be used to
diagnose HAT
Cerebrospinal Fluid Tests can also be
used.
• Look for presence of trypanosomes
• High levels of CSP protein and WBCs
Complete Blood Count (CBC) are
another test used.
• Look for high levels of immunoglobulin
protein M
• Anemia
• High levels of White blood cells
Melarsoprol used to be the most
common treatment.
• Arsenic based
• Kills 5% of patients
“Like fire in the veins”
Eflornithine had less side effects but
was far too costly and inconvenient
• 1 hour infusions, every 6 hours for 2 weeks
• $655
Nifurtimox-Eflornithine Combination
Therapy (NECT) is the first new
treatment in 25 years
• On WHO’s Essential Drugs List (2009)
• $330
NECT has considerably less side
effects.
• 86% Experienced Side effect
• 37.9% Mild
• 54.7% Moderate
Work to find new treatments is being
done right here in North Carolina
“it will be the first new, orally active treatment
for sleeping sickness in the past 30 years”
Currently, the PATTEC is attempting to
eradicate HAT.
Resources
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"About Us." Open Positions. N.p., n.d. Web. 01 Nov. 2012. <http://www.scynexis.com/about-us/life-at-scynexis/open-positions/>.
"Www.africa-union.org." Www.africa-union.org. African Union, Feb. 2007. Web. 07 Nov. 2012. <http://www.africa-union.org/root/au/index/archive_February_2007.htm>.
Alirol, E., D. Shrumpf, JA Heradi, C. De Patoul, M. Quere, and F. Chappuis. "Result Filters."National Center for Biotechnology Information. U.S. National Library of Medicine, 12 Oct. 2012.
Web. 01 Nov. 2012. <http://www.ncbi.nlm.nih.gov/pubmed/23074318>.
"Children's Health." Cerebrospinal Fluid (CSF) Analysis. Encyclopedia of Children's Health, n.d. Web. 01 Nov. 2012. <http://www.healthofchildren.com/C/Cerebrospinal-Fluid-CSFAnalysis.html>.
"DPDx - Trypanosomiasis, African." DPDx - Trypanosomiasis, African. Centers For Disease Control, n.d. Web. 01 Nov. 2012.
<http://www.dpd.cdc.gov/dpdx/HTML/TrypanosomiasisAfrican.htm>.
"Improved Treatment for Sleeping Sickness Now Available." Doctors Without Borders. Drugs for Neglected Diseases Initiave, n.d. Web. 01 Nov. 2012.
<http://www.doctorswithoutborders.org/press/release.cfm?id=4029>.
Leslie, Mitch. "Hitting Sleeping Sickness Where It Lives." - ScienceNOW. ScienceNOW, 28 June 2011. Web. 01 Nov. 2012. <http://news.sciencemag.org/sciencenow/2011/06/hittingsleeping-sickness-where-.html>.
Moore, Anne. "Chapter 3Infectious Diseases Related To Travel." Trypanosomiasis, African (Human African Trypanosomiasis, African Sleeping Sickness). Centers For Disease Control, n.d.
Web. 01 Nov. 2012. <http://wwwnc.cdc.gov/travel/yellowbook/2012/chapter-3-infectious-diseases-related-to-travel/trypanosomiasis-african-human-african-trypanosomiasis-africansleeping-sickness.htm>.
N.p., n.d. Web. <http://drugline.org/img/ail/3204_3227_2.jpg>.
N.p., n.d. Web. <http://wiki-images.enotes.com/thumb/0/02/Melarsoprol.png/280px-Melarsoprol.png>.
Odero, Randy O. "African Trypanosomiasis (Sleeping Sickness)Â Workup." African Trypanosomiasis (Sleeping Sickness) Workup. Medscape, 11 Jan. 2012. Web. 01 Nov. 2012.
<http://emedicine.medscape.com/article/228613-workup>.
"Pan African Tsetse and Trypanosomiasis Eradication Campaign - PATTEC | African Union."Pan African Tsetse and Trypanosomiasis Eradication Campaign - PATTEC | African Union.
African Union, Web. 01 Nov. 2012. <http://au.int/en/dp/rea/RO/PATTEC>.
"Parasite Museum." Trypanosome. N.p., n.d. Web. 01 Nov. 2012. <http://www.parasitemuseum.com/trypanosome/>.
"Seattle BioMed." African Sleeping Sickness. Seattle Biomed, n.d. Web. 01 Nov. 2012. <http://www.seattlebiomed.org/disease/african-sleeping-sickness>.
"Sleeping Sickness." Sleeping Sickness. U.S. National Library of Medicine, 18 Nov. 0000. Web. 01 Nov. 2012. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002338/>.
"Tarangire." Tarangire. N.p., n.d. Web. 01 Nov. 2012. <http://www.marlaine.com/personal/africa/Tanz/tarangir.htm>.
"Trypanosomiasis, Human African (sleeping Sickness)." WHO. World Health Organization, Oct. 2012. Web. 01 Nov. 2012. <http://www.who.int/mediacentre/factsheets/fs259/en/>.
"Tsetse Fly (insect)." Encyclopedia Britannica Online. Encyclopedia Britannica, n.d. Web. 01 Nov. 2012. <http://www.britannica.com/EBchecked/topic/607699/tsetse-fly>.
"WHO Report on Global Surveillance of Epidemic-prone Infectious Diseases - African Trypanosomiasis." WHO. World Health Organization, n.d. Web. 01 Nov. 2012.
<http://www.who.int/csr/resources/publications/CSR_ISR_2000_1tryps/en/index.html>.
McCann, Peter M., and Anthony E. Pegg. "Ornithine Decarboxylase as an Enzyme Target for Therapy." Science Direct. N.p., n.d. Web.
<http://www.sciencedirect.com/science/article/pii/016372589290032U>.