Transcript PPT Version - OMICS International

Denis Hadjiliadis MD, MHS, FCCP, FRCP(C)
Paul F Harron Jr, Associate Professor of Medicine
Division of Pulmonary, Allergy and Critical,
Perelman School of Medicine, University of Pennsylvania
Director, Adult Cystic Fibrosis Program
Member, Lung Transplantation Program
Biography
• Denis Hadjiliadis did his undergraduate studies at McGill University
in Montreal, Canada and completed his MD at the University of
Toronto, in Canada in 1995.
• He subsequently pursued training in Internal Medicine at the Mayo
Clinic and Pulmonary and Critical Care Medicine at Duke University,
where he also completed a Master’s of Health Sciences in 2001.
Further training was pursued in Lung Transplantation and Cystic
Fibrosis at the University of Toronto, completed in 2002.
• He joined the faculty at the University of Toronto in 2001 as an
instructor and as Assistant Professor in 2003, where he was also the
Medical Director of the B4 hospitalist unit (included chronic
ventilators).
Biography
• He joined the University of Pennsylvania in 2005 as the Associate
Medical Director of the Lung Transplant Program (a position he
stepped down from in 2012, but he remains an active member).
• He has been the Adult Program Director of the Cystic Fibrosis
Program since 2009 and the local Principal Investigator for the
Cystic Fibrosis Therapeutic and Development Network and the
medical lead for the Advanced Lung Disease Clinical Research
group.
• He is currently the Paul F Harron Jr Associate Professor of Medicine,
at the Perelman School of Medicine of the University of
Pennsylvania.
Biography
• Dr Hadjiliadis has a very active practice in one of the largest Adult
Cystic Fibrosis Programs in the country and also manages patients
before and after lung transplantation, mainly with cystic fibrosis. He
also sees patients with bronchiectasis
• He is part of multidisciplinary teams in treating all the above
conditions and is very experienced in providing multidisciplinary
care
• He is involved in the education of medical students, residents,
fellows and allied health professionals (including nurses and nurse
practitioners) in many ways including, clinical teaching, didactic
lectures and small group sessions
Biography
• He has been the local PI for many clinical trials mainly in
the disease areas of CF and bronchiectasis, including
antibiotic and anti-inflammatory trials for these diseases
(inhaled aztreonam, levofloxacin, ciprofloxacin and
vancomycin are some of the agents studied)
• He also has been involved in many investigator initiated
clinical trials in areas of susceptibility to Pseudomonas
infection, inspiratory muscle strength and training in CF,
use of flaxseed in CF and many others, some of them as a
PI and others as a collaborating physician
Research interests
• Susceptibility of CF patients to Pseudomonas acquisition
• Prediction of outcomes in patients with advanced CF requiring
lung transplantation
• Variation of CF mucous and lung disease during menstrual
cycle
• Inspiratory muscle strength in patients with CF; implications
for prediction of weakness and training
Research interests
• CF related diabetes; pathogenesis and mechanisms of
progression as well as treatment
• Anti-inflammatory and anti-oxidant diet, in patients with CF,
more specifically flaxseed
• Pregnancy in cystic fibrosis
• New CF modifier treatments in patients with rare mutations
Research interests
• Transition of care of young adults with CF from pediatric to
adult hospitals
• Use of voriconazole after lung transplant
• Development of immunity against wild-type CFTR in aptients
with CF
Selected references
•
Martine Loeve, Wim C. J. Hop, Marleen de Bruijne, Peter Th. W. van Hal, Phil
Robinson, Moira L. Aitken, Jonathan D. Dodd, Harm A. W. M. Tiddens, on behalf of
the Computed Tomography Cystic Fibrosis Survival study group: Chest Computed
Tomography scores are predictive of survival in CF patients awaiting lung
transplantation. American Journal of Respiratory and Critical Care Medicine 2012
Notes: I am part of the Cystic Fibrosis CT Survival Study Group.
•
Rebecca E. Colman; J. Randall Curtis; Judith E. Nelson; Linda Efferen; Denis
Hadjiliadis; Deborah J. Levine; Keith C. Meyer; Maria Padilla; Mary Strek; Basil
Varkey; Lianne G. Singer: Barriers to Optimal Palliative Care of Lung Transplant
Candidates. Chest Page: doi:10.1378/chest.12-0830, 2012 Notes: online first.
•
Lipson David A, Holsclaw Douglas, Imbesi Giovanna, Ferrin Marianne, Sims
Michael, Miller Sam, Tal-Singer Ruth, Hadjiliadis Denis2: Evidence of Elevated
CXCR2 Agonists in Stable Outpatients with Cystic Fibrosis Compared with Healthy
Controls. Journal of Pulmonary and Respiratory Medicine 3: 149, 2013.
Selected references
•
Monica Ahluwalia, Jeffrey B. Hoag, Anas Hadeh, Marianne Ferrin, Denis Hadjiliadis:
Cystic fibrosis and pregnancy in the modern era: A case control study. Journal of
Cystic Fibrosis 2013.
•
Kreider ME, Hadjiliadis D, Kotloff RM: Candidate Selection, Timing of Listing, and
Choice of Procedure for Lung Transplantation Clinics in Chest Medicine 32(2): 199211, Jun 2011 Notes: Accepted for publication.
•
Mogayzel PJ Jr. Naureckas ET. Robinson KA. Mueller G. Hadjiliadis D. Hoag JB.
Lubsch L. Hazle L. Sabadosa K. Marshall B. Pulmonary Clinical Practice Guidelines
Committee.: Cystic fibrosis pulmonary guidelines. Chronic medications for
maintenance of lung health. American Journal of Respiratory and Critical Care
Medicine 187(7): 680-9, April 2013.
Selected references
•
Hadjiliadis D: Why should we bother diagnosing cystic fibrosis in adult patients?
Journal of Pulmonary and Respiratory Medicine(1), e102, 2011.
•
Morales P, Santos M, Hadjiliadis D, Aris RM: Mycobacterial Infections in
Cardiothoracic Transplantation Diagnosis and Management of Infectious Diseases
in Cardiothoracic Transplantation and Mechanical Circulatory Support. Martha L.
Mooney, Margaret M. Hannan,and Shahid Husain (eds.). International Society for
Heart and Lung Transplantation, Page: 161-173, 2011.
•
Hadjiliadis D: Expert Commentary for "A CFTR potentiator in patients with cystic
fibrosis and the G551D mutation" N Engl J Med. 2011;365:1663-72. ACP Journal
Club, 2012.
•
•
Hadjiliadis D: Are Macrolides the Pulmonologists' "Statin"? Journal of Pulmonary
and Respiratory Medicine