Transcript FY02 Business Strategy

Dr. Peter J.E. Verdegem
Chief Science Officer
Cellular Essentials
™
Causes of Death in South East Asia
Liver
Respiratory
External
Suicide
MVA
Homicide
Infections
Stroke
Digestion
Cancer
Cardiovascular
Cardiovascular Disease
• Cardiovascular disease - the single leading cause of death
in South East Asia
• Millions of individuals in South East Asia have have
angina, have had a heart attack or other forms of
cardiovascular disease.
• Most women have a fear of breast cancer, yet are actually
ten times more likely to die from cardiovascular disease.
Causes of Cardiovascular Disease
Genetics
Smoking
Atherosclerosis
Myocardial Ischemia
Arythmia, Angina, Heart Attacks
Heart Failure
High Cholesterol is a Major Culprit for
Cardiovascular Risk
MECHANISM
Mechanism: how cholesterol is deposited into the arterial wall
Starts with
LDL
Endothelial
cell
When LDL is able
to attach itself
into the arterial
wall it initiates
Lumen
Cross section of an artery
Cholesterol
deposits
•
99% of all individuals regardless of age and
sex have cholesterol plaque in the arterial
wall
Lumen
Cholesterol plaque
Atherosclerosis Timeline
Endothelial Dysfunction
Foam
Cells
Fatty
Streak
Intermediate
Lesion
Atheroma
From first decade
From third decade
Growth mainly by lipid accumulation
Stary et al. Circulation. 1995;92:1355-1374.
Fibrous Complicated
Plaque Lesion/Rupture
From fourth decade
Smooth muscle
and collagen
Thrombosis,
hematoma
Recent advances in modern
technology
•
Recent advances in modern technology such as:
(1) UltraFast Computed Tomography (CT)
(2) Ultrasound
We are now able to detect the presences of
cholesterol plaque in the arterial wall even before it
causes obstruction
 80% of males at the age of 40 have cholesterol
deposit causing luminal obstruction of about
50%
Endothelial Cell
Lumen
Cholesterol plaque
extending into the
arterial lumen 
causing obstruction
LDL  MAIN CULPRIT
Causing
Endothelial
cell dysfunction
Causing
Lumen
cholesterol
plaque rapture
Resulting in
Endothelial Cells
dysfunction
Blood clot  sudden
complete occlusion of
the blood vessels 
result: sudden death
or acute heart attack
Aggressive Modification of Risk
Factors
•
Cholesterol; triglyceride; LDL blood level
•
Age in males (80% at age 40 have cholesterol plaque – with 50%
occlusion). In females after menopause the incidence is the same as
in males. However females have a higher incidence of sudden death.
•
Family history  homocysteine – predisposes to early development
CHD (Kilmer McCully, 1969)
•
Diabetes Mellitus – better control of blood sugar
•
Hypertension – better control of blood pressure
•
Smoking – stop smoking reduce risk to about 10%
Primary Prevention
•
Cellular Essentials when used at an early age prior to cholesterol plaque
extending into the arterial lumen has been shown to dissolve or reverse
cholesterol deposition
Primary
prevention:
Lumen
Secondary prevention: Cellular
Essential can prevent progression of
arterial narrowing
(Soft
cholesterol
plaque)
Cellular Essential can maintain
endothelial cell function
Lumen
CardioBasics
A blend of vitamins, minerals and amino acids formulated
to promote supple, more reactive blood vessels.
CardioBasics
The B vitamins
Contents:
• B1 (Thiamin)
• B2 (Riboflavin)
• B3 (Niacin)
• B5 (Pantothenic Acid)
• B6 (Pyridoxine)
• B7 (Biotin)
• B9 (Folic Acid)
• B12 (Cyanocobalamin)
B-vitamins are responsible for:
•
•
•
•
•
•
Energy metabolism
Cellular replication
Homocysteine reduction
Immune system function
Synthesis of biomolecules
Detoxification & Liver support
CardioBasics
The other vitamins and
minerals
•Vitamin A
•Vitamin C
•Vitamin D
•Vitamin E
•Calcium
•Phosphorus
•Magnesium
•Zinc
•Selenium
•Copper
•Manganese
•Chromium
•Molybdenum
•Potassium
Vitamins and minerals are
responsible for:
• Ensuring optimal nutrition levels
for the heart
• Ensuring optimal protection levels
for the heart
CardioBasics
The amino acids
Proline
Lysine
Arginine
Carnitine
Cysteine
Amino acids are responsible for:
• Protein synthesis
• Selection known to strengthen the
heart muscle
L-Carnitine
• Amino acid, although strictly speaking not
• Belongs more to the B vitamins
• Body can synthesize if enough iron, vitamin B1,
vitamin B6, lysine, and methionine are present
• Dietary source is meat
L-Carnitine
• Transfers long-chain fatty acids into the
mitochondria
• Fuels the energy factories of the heart
• 70% of the heart energy comes from fatty acid
breakdown
• In 1978, the first cardiovascular anti-ischemic
effect was demonstrated and improvements in
Electrocardiogram measurements
Mitochondria
Mitochondria
CardioBasics
The other ingredients
Inositol
Coenzyme Q10
Pycnogenol
Other ingredients are responsible
for:
• Prevent hardening of the arteries
(inositol)
• Boost cardiac energy (CoQ10)
• Antioxidant protection
(Pycnogenol)
Coenzyme Q10
• Small fat soluble molecule with three distinct functions:
• Transport of electrons to mitochondria, essential for
energy production
• Fat soluble antioxidant protecting a.o. LDL particles
• A high concentration of Co Q10 is found in the heart muscle
Coenzyme Q10
• Functions in energy production within the mitochondria
• Deficiency states have been demonstrated in the research
to be associated with many diseases, primarily
cardiovascular
(Bliznakow EG, et al. Adv in Ther. 1998;15(4):218-228)
Coenzyme Q10
• Over 40 human clinical trials have been conducted in
relation to cardiac parameters
• Meta-analysis on 8 studies showed significant effects for
ejection fraction, cardiac output, stroke volume, enddiastolic volume (Soja, 1997)
• Although statin drugs are used to reduce cardiovascular
morbidity and mortality, they consequently lower Co Q10
levels
Bio-C
Ascorbic Acid
(Vitamin C)
Ascorbic acid can be bound to the
long-chain fat, palmitic acid to
form Ascorbyl palmitate. A fatsoluble form of Vitamin C. This
is stored in the body and allows
Vitamin C to get into fatty tissue.
This includes atheromas.
Vitamin C is usually known as
a water-soluble vitamin. The
body does not store it and any
excess is removed from the
body through urine.
Ascorbyl
Palmitate
Cellular Essentials™
• Clinical Study with Nutritional supplement
Program in Coronary Atherosclerosis cases
• Niedzwiecki, et al. J. of Applied Nutrition (48)
1996.
• After 12 months of supplementation:
– 15% reduction in further calcification of the
coronary arteries
– in a subgroup of early CAD cases complete
stop of further calcification and even reversal
Multi Action System
Improving
heart
function
Reduction of
cholesterol
Giving more
energy