Transcript cardiovascular6

Lab This Week:
EKGs and Blood Pressure
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Bring textbook
Bring calculator
Wear clothes and shoes for running stairs
Easy access to wrist and ankles for ECG
electrodes
• Easy access to arms for Blood Pressure
measurement
• Wear Wofford logo if you wanna be in Olencki pics
Revising Abstracts
Instructions forthcoming.
Due date to be announced.
Keep all papers together for resubmission!
For Friday Quiz
• Be prepared to draw and label
electrocardiograms for
– Normal
– 1st degree heart block
– 2nd degree heart block
• Be able to diagnose from an ECG
– Atrial fibrillation
– Ventricular fibrillation
– Premature ventricular systole
– 3rd degree heart block
1QQ#26 for 10:30
a) Catecholamines acting on beta-adrenergic
receptors cause arteriolar smooth muscles to
relax.
b) Vasopressin is a vasoconstrictor.
c) Of the several modes of exchange in capillaries,
diffusion is the most important for the delivery
of nutrients and removal of wastes.
d) There are five Starling forces.
e) For bulk flow, water and colloids move through
aqueous channels and intracellular clefts.
e) Was not graded. I intended the term to be intercellular clefts and I didn’t
do a good job of making a distinction.
1QQ#26 for 11:30
a) Catecholamines acting on alpha-adrenergic receptors
cause arteriolar smooth muscles to relax.
b) Endothelin-1 is a vasoconstrictor.
c) Of the several modes of exchange in capillaries, bulk
flow is the most important for the delivery of
nutrients and removal of wastes.
d) There are only three Starling forces.
e) During bulk flow in capillaries, water and crystalloids
move through aqueous channels and intracellular
clefts.
e) Was not graded. I intended the term to be intercellular clefts and I didn’t
do a good job of making a distinction.
S 10
Bulk Flow through aqueous channels and intracellular clefts
Figure 12.42
Regulated
by arterioles
Starling Forces
Net filtration = 4L/day
Main difference in the Pulmonary circuit?
Bulk Flow and Starling Forces
S 12
Who Cares?
Aunt Esther
Cancer of the liver;
Failure of hepatocytes to
produce plasma colloids
Aunt Ester
Pc
∏c
Hypotension
∏c
Pc
Actions of Histamine
and antihistamines
S 11
Fig. 12.43
Pc
Pc
Pc
S1
Figure 12.47
Fate of 4 L/d excess filtrate
Mode of propulsion?
Liver &
Bone Marrow
& Spleen
Filariasis in Haiti: Washington Post Article
S2
Veins are
Capacitance vessels
(high compliance)
with valves for
unidirectional flow
Figure 12.44
Arteries are
low compliance,
so any increase in
volume increases
pressure.
S3
MAP = CO x TPR
Fig. 12.53
Negative feedback control:
stimulus,
receptors,
afferent pathway(s),
integrator,
efferent pathway(s),
effector(s)
response(s)
S4
Fig. 12.54
What happens to the set point for MAP during exercise?
S5
Story Time
A Neuroscientist in New Orleans
S2
Mean Arterial Pressure = Cardiac Output x Total Peripheral Resistance
MAP = CO x TPR
MAP = (HR x SV) x TPR
Loss of 1 liter of blood from vein → ↓ blood volume → ↓ MAP → …..
Creating your Hemorrhage Diagram
Beginning with a loss of about 1 liter of blood from a vein, diagram the
early events associated with hemorrhage and the negative feedback
responses to hemorrhage in a well-organized diagram. Write legibly!
Completeness, accuracy, and detail, together with the proper
sequence earn maximal points.
The following abbreviations can be used: AI, AII, JGA, mAChR, Hct, Q, SV,
EF, RBC, HR, EDV, ACh, ANH, ADH, CO, TPR, EPO, VR, MAP, EPI, NE,
SAN, aAdR , bAdR, Symp (sympathetic), Parasymp (parasympathetic), PV,
r (radius), Pc, fAP (frequency of action potentials.) Any other abbreviations
must be defined. "If in doubt, write it out!" Use single headed arrows (→)
to indicate sequential relationships and doubled-stemmed arrows to
indicate increases or decreases.