Transcript EXTRINSIC INNERVATION OF THE HEART

CARDIAC REGULATION
EXTRINSIC AND INTRINSIC
MECHANISMS
Guido E. Santacana Ph.D.
Professor
Dept. of Physiology
Control of Cardiac Activity
CARDIAC OUTPUT = HEART RATE X STROKE VOLUME
Pacemaker
Activity
Myocardial
Performance
TWO POINTS TO REGULATE
EXTRINSIC REGULATION
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AUTONOMIC NERVES
BARORECEPTOR REFLEX
BAINBRIDGE REFLEX
RESPIRATORY EFFECTS
CHEMORECEPTOR REFLEXES
VENTRICULAR RECEPTOR REFLEX
HORMONAL REGULATION
EXTRINSIC REGULATION
HEART AND BLOOD VESSELS
EXTRINSIC INNERVATION OF THE
HEART
THORACIC
CERVICAL
MEDULLA OBLONGATA
R
VAGUS
SAN
EPICARDIAL PLEXUS
L
CORONARY
VESSELS
AVN
MYOCARDIUM
SYMPATHETIC VS VAGAL
STIMULATION AND DECAY
VAGAL
SYMPATHETIC
PARASYMPATHETIC / SYMPATHETIC
REASONS FOR STIMULATION/DECAY
DIFFERENCES
VAGUS
SYMP.
Ach
NPY
NE
K+
Ach
M
REUPTAKE
ATROPINE
NE
B BLOCKERS
AchE
DIFUSSION
B1
cAMP
EFFECTS OF
CATECHOLAMINES
EPINEPHRINE
NOREPINEPHRINE
BARORECEPTOR REFLEX
AORTIC ARCH
CAROTID SINUS
200
HEART
RATE
B/M
50
ARTERIAL PRESSURE
mmHg
150
BAINBRIDGE VS BARORECEPTOR
REFLEXES
VOLUME LOAD
INCREASED RA PRESSURE
+
CO
+
ARTERIAL
PRESSURE
+
ATRIAL RECEPTORS
BARORECEPTOR
REFLEX
+
BAINBRIDGE
REFLEX
+
+
HEART RATE
RESPIRATORY REGULATION
OF CARDIAC ACTIVITY
INSPIRATION
BARORECEPTOR REFLEX
+
+
ARTERIAL PRESSURE
INTRATHORACIC
PRESSURE
CO
+
+
VENOUS RETURN
BAINBRIDGE
PERIPHERAL CHEMORECEPTORS AND
HEART RATE
PERIPHERAL
CHEMORECEPTORS
+
MEDULLA
+
RESPIRATORY
ACTIVITY
DAMPENING OF
CARDIAC EFFECT
HEART
RATE
VENTRICULAR RECEPTOR
REFLEX
VASOVAGAL SYNCOPE
STANDING
VENTRICULAR CONTRACTION
VENOUS POOLING
VENOUS RETURN
SYMPATHETIC
ACTIVITY
CO
MAP
BARO
REFLEX
HUMORAL REGULATION
INSULIN
THYROID
GLUCAGON
dP/dt
CATECHOLAMINES
POTENTIATION
STEROIDS
RENIN-ANGIOTENSIN
ATRIAL NATRIURETIC PEPTIDE
ENDOTHELIN
ANTIDIURETIC HORMONE
INTRINSIC REGULATION
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FRANK STARLING
HEART RATE AND FORCE
INTRINSIC REGULATION
OF THE HEART
FRANK STARLING LAW OF THE HEART
AND BACK TO THE VENTRICULAR FUNCTION CURVE :>)
LVP
EDV
FORCE DEVELOPED(G)
FORCE DEVELOPMENT
.32
1.6
180
INTERVAL BETWEEN CONTRACTIONS(SEC)
REGULATION OVERVIEW