Transcript Folie 1

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IOM3 9.11. 2009
Ultra thin ,prophylactic, “Liquid
Glass” coatings (SiO2) for use
in Health Care and associated
environments.
Neil McClelland
UK Project Manager
Nanopool GmbH
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Key areas covered in this presentation
• Description of the technology
• Test data associated with the
technology
• Areas of application
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• Nanopool are currently regarded as
world leaders in the field of Si02 ultra
thin layering technology.
• We supply our multi award winning
technology to a very wide range of
markets, including the retail sector.
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Introduction
• NP coatings are nano scale ( 80100nm +/-) but do not contain
discrete or engineered nano
particles.
• A nanometre is equivalent to a
millionth part of a millimetre = 10-9 m
• A human hair is approximately
50,000 nm thick, therefore our
coatings are approximately 500
times thinner than a human hair.
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So what is in the bottle?
Molecules of SiO2 and water
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Molecules of SiO2 and ethanol
SiO2 is a well understood in the macro world . It consumed daily by humans and whales!
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NP-Nano Layers
• By applying a modified SolGelprocess we generate ultra thin SiO2coatings
• SiO2 is pristine glass. One of its
really exciting characteristics is an
extremely low surface tension
• It is very hydrophobic and
simultaneously oleophobic. (We use
the term super-phobic.)
np-nano coating
Organized, webstructured
SiO2-molecules
Substrate
Some further characteristics of nanopool’s
easy to clean protective coatings
•The coatings are easy to apply via -wiping, spraying or
dipping.
•Re application is very simple.
•The coatings can be applied to almost any surface,
including skin. All coatings are breathable (allow diffusion).
•Super-phobicity ensures stain protection. Soiling agents
are unable to adhere to the surface.
•The coatings are highly durable, lasting years in many
instances. Our coatings will withstand tens of thousands of
wiping actions
•All coated surfaces can, in most instances, be cleaned
with water alone. (This observation is supported by a range
of test data.)
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NP-Nano Layers
• The SiO2 skin is enormously
flexible, acid and alkaline resistant
and withstands extreme
temperature changes -150 to +450C
• Resistant to Acid and Alkali
• ph-Value 0.5 – 12 (14 depending on
type of substrate)
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•All of Nanopool’s coatings are “cationic” and
therefore provide biostatic characteristics.
•We also offer an Anti Bacterial range of
coatings which contain triclosan within the
matrix. These products conform to ASTMs e
2180
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Fabric Treatment
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This image shows the coating on a micro fibre. (The fissure was
induced.)The corrugated appearance indicates the flexibility of the
coating
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AFM Images showing topography of coated surface
Uncoated surface scale 2.0µm
Coated surface . Scale 1 µm
Glass substrate
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NP-Nano Layers
Ultra thin Layer on a metal substrate
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Flexibility
• coated polypropylene . 90 degree bend indicating flexibility
• Our coatings are flexible ( 200%)
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Antimicrobial Characteristics
• The hydrophobic and oleophobic function
of the SiO2-coating impedes the
colonization of surfaces
• The strongly cationic characteristic of the
SiO2-Triclosan (or Chitosan under
development )-Matrix results in enormous
weakening of the cell walls through ion
exchange reactions.
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Antimicrobial Characteristics
• The cytoplasm and its membrane are
encapsulated in an inflexible cell wall.
• Bacteria are classified into two different
categories – gram-positive and gram-negative.
• Gram-positive bacteria have a thick, simple cell
wall structure (20-80 nm), consisting of
peptidoglycan; opposed to this ,gram-negative
bacteria have a thin but complex cell wall
structure consisting of an outer membrane (7,5-10
nm) and underneath a thin layer of peptidoglycan
(5-10 nm).
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Antimicrobial Characteristics
• The cationic ( pos. charged) “donatingagent” is absorbed on the negative
charged surface of the bacteria.
• Then it diffuses through the cell wall
• It bonds to the cytoplasm membrane.
• This causes the decomposition of the
cytoplasm membrane.
• This leads to the disintegration of the
cytoplasm components.
• The cell dies. Ref ASTM e2180
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Antimicrobial Characteristics
• Contributes to Hygiene and Cost
Savings
– Easy-to-Clean-characteristic = easier
and faster cleaning (audited figures
suggest an overall saving of 35%)
– Actively and constantly reduces the
microbial level
– Prevents or inhibits microbial growth
– Has a bactericidal, fungicidal and
algaecide function
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Certificates and Expertises
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anti bacterial effect -fabric coated in SIO2
Hemmhof protocol - conducted by the IBFE organisation
This image shows the effect on Staphylococcus aureus bacteria
around a sample fabric coated with NP Fabric Protect anti-bac
(right) and a sample coated with NP 12 anti-bac variant(left), after
a 24 hour incubation at 36°C.
“As a result it can be stated that there is a diffusion of
antibacterially effective compounds on the coated samples”
PD Dr. Thomas Jahns /Dr.Heiko Ewen
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Certificates and Expertises
EU VO 1935/2004
Food safety.
• Ultra thin layers generated with
nanopool products are according to
EU 1935/2004 applicable in food and
beverage production processes
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ASTM s E 2180
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Quantitative definition of the antimicrobial effects
according to ASTM Standard E2180
Institut Fresenius
Product: np liquid glass antibac
Sample denomination: ceramic disc covered with np liquid glass
antibac
Incubation tempertaure: bacteria 36°C ± 2°C
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Expert assessment:
• “The product has significant, strong bactericide
effects on the implemented testing germ( after 5
days residence time) Escherichia Coli,
Staphylococcus aureus and Salmonella
aeruginosa.”
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EN 1040
The results show living organism number after 60 minutes 0/0
“ Reduction of living germ number > 105””
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Anti microbial effect of “standard” coatings
Nanopool GmbH provided two cooking pot samples (one untreated, one treated with
“Die Nanoexperten – pot and oven protect”). The pots were tested for
antimicrobial effectiveness by being contaminated artificially with a suspension
of Staphylococcus aureus , residual bacteria were recovered from the surfaces by adhesive film
tests
Cooking pot treated with “Die Nanoexperten – Cooking pot
and oven protect”
Bacteria re-extracted by adhesive film tests ( each in parallel) of a
treated and untreated cooking pot
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coated
uncoated
• T0
260/244
284/302
• T1
154/140
225/222
The tests for the antimicrobial effectiveness have been carried out at room
temperature (23°C). 100 ml of the bacteria suspension was placed in each
cooking pot (germ density about 2,8 x 106/ml) and was incubated for 5 min. with
gentle shaking. Afterwards the pots were cleared and after drying of the surface
at 36°C two adhesive film tests on yeast extract-peptone-media (YEP) taken (point of time T0). Then the pots have been rinsed out each one time with
100ml de-ionised water (5 min. with gentle shaking) and again cleared.
After drying of the surfaces two adhesive film tests were taken once more on
the yeast extract-peptone-media (point of time T1). Table 1 shows the values gained
at the respective points of time for the re-extracted germs of the treated resp.
untreated pot.
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Issues
• Preparation
• Applying in a busy working
environment
• Cleaning regimes.
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Preparation
• Almost all surfaces can be coated with great
ease but…
• the surface to which the coating is applied
has to be completely clean. A fingerprint
can be 100 times thicker than the coating.
• Application to surgical devices and stand
alone equipment is straight forward.
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Uses within Healthcare
• The potential uses within Health Care are
almost endless. The following images are
from Health care environments
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Cleaning equipment with water
The left hand side of this equipment is coated with SiO2 and it
is cleaned daily with water. The right hand side is not coated ; it
is also cleaned daily with water.
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On going trials
Stents
General medical
instruments
Clothing and special fabrics
Endoscopes -SiO2
coatings inhibit the
adhesion of prions
Suture materials coated to inhibit infection
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Application within “Live” working environments
• Coating surfaces within a busy
hospital presents issues re cleaning
and post application drying times for
thicker coatings. EG flooring/fabrics.
• Thinner coatings can be handled in 2-3
minutes.
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Cleaning Regimes
• The SiO2 coatings can be cleaned efficiently with
warm water. Test data available
• Many cleaning products deposit surfactants and
residues on the coating and thus limit the efficacy of
the coating.
• Coated surfaces can be rejuvenated after prolonged
use by wiping with alcohol.
• We suggest that NP coatings are used as part of a
cleaning and disinfection regime. We do not suggest
that disinfection is no longer required in Healthcare
environments after surfaces have been coated with
SiO2.
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Summary
• There are only a few companies world-wide
which are involved in developing this form of
technology . Of these few only nanopool
offers a full range of finished products
• Our products are certified as being
environmentally friendly , and physiologically
harmless.
• This is a “low cost high benefit” technology.
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Thank you very
much for your
attention!