Transcript Complex Lipid Metabolism

Functions of Phospholipids and Glycolipids
1. Transport of lipids in the blood.
2. Formation of tissue fat.
3. Anchoring certain cell surface proteins like, alkaline
phosphatase, lipoprotein lipase and acetylcholine
esterase.
4. Antigenic determinant and cell interactions.
5. Source of arachidonic acid.
6. Hormone second messenger.
7. Hypersnsitivity and inflammatory reactions.
8. Blood clotting.
9. Solubility of cholesterol in bile.
Phospholipids
Glycerophospholipids
Phosphatidic acid
Lecithins
Cephalin
Cardiolipin
Sphingophospholipids
Plasmalogens
PAF
Ceramide
Sphingomyelins
Platelet Activating Factor (PAF)
*It is a choline plasmalogen with palmityl alcohol In
position 1 and acetyl radical in position 2 of glycerol.
*It is synthesized and liberated by granulocytes and
macrophages in response to specific stimulation by
the specific antigen.
Functions Of PAF
1- It is a mediator of acute inflammatory
reactions, hypersensitivity reactions and
anaphylactic shock.
2- It produces edema, vasodilatation and
bronchospasm.
3- It activates neutrophils and macrophages to
produce superoxide radicals that help in killing
bacteria.
4- It causes platelet aggregation as low as 10-11
mol/l