Bacterial Infections
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Transcript Bacterial Infections
Bacterial Infections
HB6
2010
Bacteria are:
Unicellular
Small (1-4mm)
Prokaryotes- no nucleus or membrane bound
organelles
Different metabolic reactions to us (peptidoglycan
cell wall)
Different sources of energy
Photosynthetic
bacteria
Chemosynthetic bacteria
Pathogenic bacteria are heterotrophs- get energy from
other organisms
Generalised bacterial cell
Escherichia coli
Bacterial shapes
Bacterial naming
Bacteria are usually referred to by
their binomial name:
Genus species
e.g. Escherichia coli
This may include Latin words referring to
the shape, disease caused by the
bacterium, or other properties
Some examples:
Helicobacter pylori
Staphylococcus aureus
Staphylococcus epidermis
Streptococcus pneumoniae
Vibrio cholerae
Neisseria meningitidis
Neisseria gonorrhoeae
Mycobacterium tuberculosis
Mycobacterium leprae
Gram positive
Thick cell wall containing
mostly peptidoglycan
Gram negative
Cell wall contains less peptidoglycan
& more lipid
Aerobic
Use oxygen for metabolism
Anaerobic
Don’t use oxygen for metabolism,
oxygen may be highly toxic to them
Bacterial
reproduction
Bacteria have a short
generation time (as short as
20min)
Bacteria reproduce binary
fission:
The DNA is replicated
The cell elongates in the middle
The cell wall & cell membrane
pinch inwards
Two cells separate
Why are bacteria so successful?
They reproduce quickly
They evolve quickly (e.g. antibiotic
resistance)
They can live in extreme environments (e.g.
in hot pools- 90oC)
Some can form endospores, which can
survive for many years (e.g. anthrax)
Not all bacteria are bad!
Lactobacillus- ferment milk to make
yoghurt and cheese
Bacteria are decomposers- break
down dead organisms and sewage
and recycle the nutrients
There are millions of bacteria in our
digestive systems- these produce
vitamin K (needed for blood clotting)
Bacteria as pathogens
Some bacteria which gain their energy
from other organisms can act as
pathogens
The negative effects on the host are
generally either from toxins produced by
the bacteria or from chemicals released
by damaged cells
Tetanus
Wound infection by Clostridium tetani
Produces a neurotoxin which causes a
prolonged muscle contraction
Death due to spasm of the breathing
muscles
About 10 cases each year in Australia, of
which one will die
Neonatal tetanus (often infection of the
umbilical stump) has a death rate of
approximately 75%
Gram positive
Obligate anaerobe
Forms spores which can be found in soil
Rod-shaped (‘tennis racket’)
Some pathogenic cocci
Streptococcus
pyogenes
Causes skin
infections
Chains of cocci
Staphylococcus
aureus
Causes wound
infections
Groups of cocci
Neisseria
gonorrhoeae
Causes gonorrhoea
Diplococci (pairs)
Neisseria meningitides
Causes meningococcal
disease
Diplococci
Some pathogenic spirilli
Treponema pallidum
Causes syphilis
Spirochetes (long spiral shape)
Bacterial pneumonia
Anthrax forms
spores which
remain dormant
in the ground
until they are in
hospitable
surroundings.
Some bacterial diseases
Pneumonia
Appendicitis
Meningococcal disease
Skin infections
Food poisoning
Some pathogenic bacilli
Escherichia coli
Normally found in
human intestines &
faeces
Some strains cause
severe food poisoning
Haemophilus influenzae
Causes some types of
pneumonia