Transcript Inflammation

Inflammation
What is it?
What are the stages, and
occurrences in those
stages?
Extensions?
Human Biology
Inflammation
 Attempt
to restore homeostasis
in an area.
 Injury…the inflammatory
response is initiated. Protective,
defensive.
Inflammation
 Etiologies:
Mechanical
Trauma
MVC
(collisions), Knife Wounds,
Gunshots, Surgery, twisting an
ankle, knee.
Foreign
invaders (like bacteria)
Toxins.
Entrance though skin
breaks (burn, splinter, wounds)
Inflammation
 Symptoms
Erythema
Redness,
heat
Pain
Edema
(swelling)
www.nlm.nih.gov/.../ ency/imagepages/2774.htm
Inflammation due to gout
http://www.whathealth.com/gout/picture-3.html
www.mf.uni-lj.si/.../ mullegger-4.jpg
Lyme Disease
medstat.med.utah.edu/.../ mml/hrob_99502.html
Lymphedema
Damaged, absent, malformed vessels
Note: This is
showing you an
illustration of
edema, and not
the entire
inflammatory
response.
http://meded.ucsd.edu/isp/1994/im-quiz/images/primedema.jpg
Inflammation has five basic stages:
Vasodilation
Phagocyte Migration
Nutrient/Metabolic Increase
Fibrin Formation
Pus Formation
Inflammatory Stages
1) Vasodilation and increased
permeability of blood vessels.
 Histamine
release does this at the site of
damage. Pain from damages nerve
endings.
 Chemical
released during allergy,
inflammatory response.
 Causes
redness and swelling
Inflammatory Stages
2) Phagocyte migration
White
Blood cells engulf and
destroy bacteria and dead tissue.
http://pathmicro.med.sc.edu/ghaffar/neutrophil.jpg
http://www.sirinet.net/~jgjohnso/macrophagephago3.jpg
Inflammatory Stages
3) Release of nutrients/Metabolic
increase
 Need
more energy to fight
infection/wounds.
 Cellular respiration increase
Need more energy
To deal with this
Mechanically wounded epithelium forming
New junctions (arrow). (false color)
ls.berkeley.edu/bio/ gallery_mcb/wound.html
Inflammatory Stages
4) Fibrin Formation
 Soluble
protein called fibrinogen coverts
to fibrin.
 Traps bacteria at the site to isolate
infected/damaged area.
http://www.chestpainperspectives.com/images/cpp_images/Fibrin.jpg
Inflammatory Stages
5) Pus Formation
Thick
fluid containing live cells,
dead cells, bacteria, white blood
cells.
192.107.108.56/.../ pictureglossary.htm
www.lhsc.on.ca/ wound/wounds.htm
http://www.larve.com/Images/images_legulcers/magots_small-cavity_wound.jpg
Maggot Therapy
Do you doubt the effectiveness of
this treatment??

The pictures you will see are proof that maggot
therapy can help patients that have not
responded to conventional therapy.
Gangrenous
ulcerations
Patient was in
hospital
for 5 weeks,
receiving IV
antibiotics and
surgery.
Doesn’t look too
good.
Two weeks later,
after maggots
have been applied.
See the healthy
tissue? It is red
and bloody, but
healthy.
3 Months later…
An excellent
result.
The scarring will
fade
over the coming
months.
Surgeons had a tough
time figuring out which
was good tissue and bad
tissue, due to the
advanced nature of the
ulceration. They didn’t
want to cut too much
away.
3 years of foot ulcers in
this 70 yr. old patient.
After maggots were
applied, the wound
was cleaned, and the
dead tissue was
removed. As you
can tell, the maggots
did a much better job
than the surgeons
could.
After healing, the
wound looks
fantastic.
Two years
afterwards, the
wound had not
reoccurred.
www.ucihs.uci.edu/com/ pathology/sherman/cases.htm
Last 7 slides are from Maggot Therapy Project, University of California, Irvine.
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http://www.youtube.com/watch?v=bAY7OKp
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http://www.youtube.com/watch?v=QYhQ1Nrp
w_s&NR=1
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http://www.youtube.com/watch?v=6Xt6NWkg
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