Transcript PNI:PPT

The Immune System - The Players (not to scale):
bacteria
Virally-infected
host cell
virus
The enemy:
neutrophils
The Defense:
Monocytes/
macrophages
T-cells
B-cells
M
Interleukins
Granules with
digestive enzymes
Foreign protein,
carbohydrate,
lipid
Fragment of enemy
after engulfment
M
T cell receptor
interleukins
antibodies
Ex: 1
Experiment - Hans Seyle
Inject:organic extract; formaldehyde;
Stimuli:
Response:↑ size adrenals
↓ size thymus
Response: ↑ size adrenals
↓ size thymus
crowding; noise
does increase cortisol from adrenals cause decrease immune response (IR)?
HPA AXIS
Fisher Rats: resistant to
arthritis/inflammation
Inject: strep cell walls
Lewis Rats: susceptible to
arthritis/inflammation
Ex: 2
Inject: strep. Cell walls
Response:
++++ IR, that does
not attenuate, giving
rise to arthritis
symptoms
Response:
normal IR, that does
attenuate, no arthritis
symptoms
Inject 1: strep cell wall plus
anti-inflammatory drug (stop CRH
release from hypothalmus),
Response: rats die
Why? ________________
Inject 2: as above but
then + cortisol
Response? _________
Conclusion: ______________________
Normal mice
Ex. 3
Inject: Day 0, horse RBC
Inject: then day 6, sheep RBC
Response: Normal IR
with antibody
and T cell
activation
Response: No IR
Why?
Adrenonectomized mice (remove adrenal glands)
Inject: Day 0, horse RBC
Inject: then day 6, sheep RBC
Response: normal IR
Response: normal IR
Conclusion:
Ex. 4
Inject: bacterial cell wall into belly
Inject: IL1 into belly or blood
Response: IL1 made in brain
Response: cortisol, ACTH increase
Conclusion:
Ex. 5
First remove adrenals then protein elicit MS symptoms
+ steroid pellet implants
Conclusion:
Inject: MS protein
Inject: MS protein
Response: extensive
MS symptoms
Response?