Transcript Treatment Options for Glioblastoma Multiforme

The Chain of Logic
► WHEN
a naturally induced vaccine occurs, the
response is powerful, immediate and of
therapeutic value – to eradication in some
cases – we call these cases “spontaneous
remissions”
► Extensive
circumstantial evidence supports this
thought
► There are soluble inhibitors of the immune response
► These inhibitors corrupt the natural endogenous anticancer vaccine process
Local Immunosuppression
Prostate Cancer
Normal
Breast Cancer
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting
Proteins :: Yong A Yu 1 '3 , Shahrokh Shabahang l , Tatyana M Timiryasova2 '3 , Qian Zhang3, Richard Beltz l, Ivaylo Gentschev4 ,
Werner Goebel 4 & Aladar A Szalay 1,4,5
Known Clinical Impact of
sTNFr Removal Therapy
►
6 of 16 patients had greater than 50%
tumor reduction using an ultrapheresis
(membrane-based separation) procedure
 Lentz 1989
►
5 of 9 late-stage breast cancer patient had
measurable response with 2 full remissions
 Lentz 1997
► Presently
in clinical trial in Germany
 Biopheresis Gmbh, 2009
A Different Philosophy
Drug-based Tx
Reveal Technology
[tm]
Supraphysiologic levels
Physiologic levels
Overrides a physiologic
mechanism
Unintended side-effects
Restoration of
homeostasis
Limited side-effects
Non-invasive
Minimally Invasive
Many drugs liver/kidney
toxic
No sustainable organ
toxicity