Transcript Chlamydia trachomatis.

Designer :
徐安涛、徐滔、钊超
张慧慧、吴瑕、吴珍
A 19-year-old woman presents for the evaluation of pelvic
pain. The pain has progressively worsened over the past
week. She has also sexually active, has had 4 lifetime
partners, takes oral contraceptive pills, and occasionally
uses condoms. On examination, she appears in no acute
distress and does not have a fever. Her abdomen is soft
with moderate lower abdominal tenderness. On pelvic
examination, she is noted to have a yellow cervical
discharge and significant cervical motion tenderness. No
uterine or adnexal masses are palpated, but mild
tenderness is also noted.
A Gram stain of the cervical
discharge reveals only multiple
polymorphonuclear leukocytes.
A direct DNA probe test subsequently
comes back positive for Chlamydia
trachomatis.
Rabies virus（Negri body）
Cytomegalovirus
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TE8
TE55
1、filterable 120—200nm
2、obligate intracellular
parasite
3、a unique life cycle
Elementary body（EB) ：
extracellular ； nondividing
300nm infectious particle;
stain –gymsa blue ,macchiavello red
Initial body (reticulate
body，RB): intracellular ;0.51.2µm , binary fission , noninfectious， gymsa and
macchiavello blue , no densible
nuclear substance ,but has reticular
structure
Join the bacteria in 1973
1、contain DNA and RNA
2、cell wall
G-， similar to G- bacteria
LPS：contain genus specific epitope
MOMP: Species specific & Type specific
epitopes
encoding gene and sequence、vaccine
HSP60
Species : C.trachomatis C. pneumoniae C. psittaci C.pecorum
subspecies :Biovar trachoma LGV Biovar mouse
Types :C T (A-K, 14) LGV(L1,L2a,L2b L3;4)
No peptidoglycan but sensible to penicillin
Resistance :sensible to heat 60℃ 510min,-70℃several years; antibiotics
Endotoxoid substance
MOMP : avoid the fusion of
lysosome and vacuole of
elementary body ; HSP60
Inflammation :
necrosis
exudation
proliferation
1)Trachoma （A、B 、Ba 、C ）
Acute inflammation : weeping,viscous
suppurative secretion , conjunctival conjestion
Chronic inflammation : scarring , entropion
trichiasis etc.
2)urogenital-tract infection,
It is the main causative agent of
nongonococcal urethritis(NGU)
In men , urethritis ,epididymitis ,
In women , urethritis ,cervicitis , pelvic
inflammatory disease (PID)
3)Inclusion Conjunctivitis
newborn,adult
4)Lymphogranuloma
Venereum(LGV)
Main invade lymph tissue
A painless papule on the
genitalia that heals
spontaneously
Designer :
徐安涛、徐滔、钊超
张慧慧、吴瑕、吴珍
Polymorphonuclear
leukocyte
Extracelluar gramnegative diplococci
Intracelluar
gram-negative
diplococci
EB
Exocytosis
Heparan sulfate ;Major
outer membrane protein
(MOMP)
Phagosome
16—24 per ER
AAs &ATP etc
Primary
differentiation
EB→RB
Secondary
differentiation
RB→EB
Binary fission
RB