Transcript Tetanusx

Tetanus
Tetanospasmin Toxin
Causative Agent
Clostridium tetani
No known useful function to the bacteria
Key Points
1. Functions at the Neuro-Muscular
Junction
2.
Toxin blocks vesicles releasing GABA
(Inhibitory NT)
3. Result: Muscles do not receive the
signal to stop contraction.
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Mode of Action
NORMAL: Muscles contract and relax
based on balance between excitatory and
inhibitory neurotransmitter
“communication”.
Neurotransmitters involved: GABA
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Tetanus PSA
• Toxin Name
• Where is toxin found? (Organism? Manmade?, etc.)
Requirements
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Upload to CANVAS by Thursday AM
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You are not sitting and presenting your
disease, so if someone is looking at your slides,
everything should be clear.
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Don’t put any words on your slides that you
can’t explain if asked.
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The simpler and clearer, the better.
You should have minimal words and more
images!
Cite all your resources including images!
• Purpose of Toxin to organism
• Target Site in Humans
• What normal function is being interrupted?
(Cited Image)
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What is the altered function?
What NT’s are involved
Altered Function with cited Image
Any other cool facts?