Transcript Outline for Oncofertility Curriculum

ONCOFERTILITY
CURRICULUM
OREGON NATIONAL PRIMATE
RESEARCH CENTER
LYNDA JONES,MS
DIANA GORDON,MAT,MPH
MARY ZELINSKI,PHD
Oncofertility Curriculum
 Introduction to oncofertility –
define oncology, fertility, why this
new field is developing
 Mitosis – slides showing stages of
mitosis, cell size & rate of diffusion
lab
 Cancer – PowerPoint from
www.cancer.gov called
Understanding Cancer
Series:Cancer and other sources –
DNA structure and beta-globin
gene exercise using 3-D Molecular
Designs showing translation,
mutations, frameshifts, exons,
introns, BRCA gene activity, p53
tumor suppressor
 Cancer treatment and the
effect on reproduction– how
chemotherapies and radiation
affect reproductive tissues
 Meiosis – slides showing stages of
meiosis
 Female and male
reproductive system – ELISA
assays, staining of ovarian tissue,
and dissection of female and male
mice
 Pregnancy – what is normal,
what can go wrong, and how
can we assist infertile
couples? – ultrasound images,
sea urchin egg fertilization and
development, assisted reproductive
technologies (ART) - IVF, ICSI
 Cryobiology – slow freezing vs
vitrification, time reduced motility
by frozen and thawed sperm,
vitrification lab, compare
structures in fresh and frozen
tissue slides, unthawing of female
and male tissue
Oncofertility Curriculum, continued
 Fertility preservation options
for cancer patients under 40
years old– current technologies
for female and male cancer
patients under 40 years old prior
to receiving chemotherapy,
radiation therapy, and bone
marrow treatment, alginate lab,
implantation, S1P studies in nonhuman primates
 Stem Cells - application to
oncofertility, ethical issues
associated with stem cell research,
stem cell lab activities
 Ethical frameworks –
PowerPoint from ONSEN ethicist,
ethical issues of assisted
reproductive technologies (ART)
 Epigenetics – effect of
epigenetics on cancer and other
human diseases and inheritance
 Student case study and poster
presentations – suggestions for
patient profile and report, poster
topics, and web resources
 Biomedical Careers – explore
careers that support biomedical
research
 Additional teacher resources
– pre- survey, pre-and post-tests,
additional suggested equipment