Transcript 4 - Medicina

Assessment of Quality Of Life in patients
treated with Chemo and Radiotherapy
for Gastric Cancer: A Systematic Review
Authors: Turma 14
Supervisors: Mário Dinis Ribeiro
Cláudia Camila Dias
Professor Doutor Altamiro da Costa Pereira
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Gastric Cancer in the World
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850 000 deaths worlwide each year cause due to gastric cancer
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Men
Women
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Eucan - Database
World, age-standardized rates (per 100.000 persons.year)
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Gastric Cancer in Europe
Cumulative risk, 0-64 years
Female
Male
Eucan - Database
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Introduction
QoL after Chemo/Radiotherapy in Gastric Cancer
 Stomach
adenocarcinoma is the
most common form of
gastric cancer (95% of
the cases).1
 Stomach cancer is a
multifactorial disease:
diet, hereditary factors,
Helicobacter pylori
infection are possible
causes.
2-3
1- http://www. vidasaudavel.pt
2- http://cancer.healthcentersonline.com/gastrointestinalsystemcancer/stomachcancer.cfm
3- http://hcd2.bupa.co.uk/fact_sheets/html/stomach_cancer.html
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Introduction
QoL after Chemo/Radiotherapy in Gastric Cancer
 Treatment for gastric
cancer often involves
surgery, usually a
partial or a total
gastrectomy (removal
of stomach tissue).2
 Chemotherapy and
radiotherapy are
standard for some
stages of stomach
cancer.2
2- http://cancer.healthcentersonline.com/gastrointestinalsystemcancer/stomachcancer.cfm
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Introduction
QoL after Chemo/Radiotherapy in Gastric Cancer
 Chemotherapy is the
use of chemical agents
to stop cancer cells
from growing.
 Chemotherapy is
considered a systemic
treatment.2
 More than half of all
people diagnosed with
cancer receive
chemotherapy.2
2- http://cancer.healthcentersonline.com/gastrointestinalsystemcancer/stomachcancer.cfm
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QoL after Chemo/Radiotherapy in Gastric Cancer
 Radiotherapy uses high
energy x-rays to
destroy cancer cells.4
 A small dose of
radiotherapy may be
very helpful to relieve
pain.4
4- http://info.cancerresearchuk.org/cancerstats/types/stomach/?a=5441
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QoL after Chemo/Radiotherapy in Gastric Cancer
 These multiple
treatments have
different consequences
in de Quality of Life
 QoL cannot be yet
universally defined5,
however there are many
attempts to do so.
(QoL) in patients.
 Schipper et al. proposed:
“the functional effect of illness and its consequent
therapy upon a patient, as perceived by the patient”.6
5- Spilker B, ed. Quality of Life and pharmacoeconomics in clinical trials. Philadelphia:Lippincott-Raven, 1996
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6- Schipper H, Clinch J, Olweny LM. Definitions and conceptual issues. In: Spilker B, ed. Quality of Life and pharmacoeconomics
in clinical trials, Philadephia : Lippincott- Raven, 1996: 11-24
Aim
QoL after Chemo/Radiotherapy in Gastric Cancer
____________________________________________
• To review which instruments were used to measure
the QoL in patients with gastric cancer submitted to
chemo and radiotherapy.
• To summarize QoL measures across studies.
____________________________________________
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Methods:
QoL after Chemo/Radiotherapy in Gastric Cancer
 The MesH terms that we use were:
◊ ″Quality of Life And stomach Neoplasms
Not surgery. “
 Literature searches were conducted
in Medline.
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Limits:
 Publication Date till September 2005.
 Only items with an abstract.
 Humans.
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Methods
 Inclusion Criteria
o Articles in which QoL was evaluated in patients
with gastric cancer and were treated by chemo
and radiotherapy.
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Methods
QoL after Chemo/Radiotherapy in Gastric Cancer
• After searching in
Medline 45 articles were
found. Due to the
applying of the
inclusion and exclusion
criteria the number of
articles was reduced to
13.
Exclusion
critérium
Number of
articles
Patients with more
than one type of
cancer
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Patients with
another type of
cancer (not gastric
cancer)
4
Patients weren’t
treated with chemo
and radiotheraphy
5
QoL was not
measured
6
Other reasons
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Total of articles
excluded: 32
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Fluxogram
QoL after Chemo/Radiotherapy in Gastric Cancer
Beginning
Read title and
abstract
Excluded by 2
reviewers
Yes
No
Exclude
article
yes
Included by 2
reviewers
Include
article
no
Opinion of a
third reviewer
Read
complete
article
Discuss until
reviewers
agreement
Introduce data in
the SPSS
Include
article
Exclude
article
End
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