Transcript iucka-ncg-08-09-16 - open health systems laboratory

IUCKA
India-United States
Cancer Knowledge Alliance
Leveraging Community and
Connectivity to Improve
Cancer Outcomes
Ken Buetow, Ph.D.
Computational Science & Informatics
Complex Adaptive Systems
ARI ZONA STATE UNI VERSITY
Outline
• Introduce the India-US Cancer Knowledge Alliance
(IUCKA)
• Briefly describe activities currently in progress
• Describe collaborative opportunities with National
Cancer Grid
• Discussion
IUCKA
India-United States
Cancer Knowledge Alliance
Unique problems
require innovative
approaches
India-United States Cancer
Knowledge Alliance (IUCKA):
A collaborative coalition of international stakeholders
committed to Improving Cancer Outcomes
What is the India-United States
Cancer Knowledge Alliance (IUCKA)?
• Public-Private Partnership of ALL Stakeholders
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Academic
Government
Industry
• National and International
• Bridging/Enabling connections
IUCKA approach:
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Leverage unique assets
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Institutional
Data
Synergize
Exploit 21st Century
Information Technology
IUCKA provides:
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Facilitation
Consultation
Services
Support
IUCKA Platform Vision
Coordinated information technology
solutions that integrate biomedical and
hospital information systems for
transforming information into evidencebased treatment knowledge
• “Virtual” communities
• Enhanced, integrated cancer registries
Monitor trends, assess success
• “Smart” Electronic Health Record
• Common, shareable
aggregated/integrated molecular and
clinical data
Centered on understanding the
mechanisms of response and unique
Indian response
• National Clinical Trials Infrastructure
Building evidence for novel clinical
interventions
Genomics
data
Clinical
Records
Integrated
data
solutions
Radiotherapy
Imaging and
other
IUCKA bridges India’s world class
capabilities
• Tata Memorial Centre
• Tata Memorial Hospital
• Advanced Center for Treatment, Research,
Education in Cancer
• The National Cancer Grid of India
• All India Institutes of Medical Sciences
• group of autonomous public medical
colleges of higher education
IUCKA
India-United States
Cancer Knowledge Alliance
IUCKA leverages India’s world
class technology capabilities
• Centre for Development of Advanced
Computing
• Bioinformatic Resources & Applications
Facility
• National Knowledge Network
• Industry
• IT’s contribution to India's GDP grew from
1.2% in 1998 to 7.5% in 2012
• aggregated revenues of US$147 billion in
2015
IUCKA
India-United States
Cancer Knowledge Alliance
CDAC/BRAF
• Health Informatics
• MEGH SUSHRUT: open source Health Information System –
deployed at 28 institutions (24 public hospitals in Rajasthan)
• Distributed Health System (DHS): Clinical Integration Platform
• Mercury™ Nimbus: Comprehensive telemedicine platform
• Cognitive Systems
• Natural Language processing
• Feature recognition
• Expert Systems
• Digital Biology
• Pan-omics capabilities – genomics, structural biology
• Federated Computational and Storage Infrastructure
• “Genomic Rigs”
• Repository
Persistent Systems
• Digital Transformation
• Connected Healthcare
• Product Engineering
• Products and Solutions
Dr. Anand Deshpande
Founder, Chairman and
Managing Director
IUCKA’s international partners
complement Indian capabilities and
facilitate bridging and support
• Open Health Science Laboratory
• Arizona State University
• ICT BioMed
• Pozan Supercomputing and Networking
Center, Poland
• Chalmers University of Technology,
Sweden
• University of Notre Dame, USA
• Internet2
• US NCI Quantitative Imaging
Network
• Harvard/Massachusetts General
Hospital
• Industry
IUCKA
India-United States
Cancer Knowledge Alliance
OHSL bridges people, domains,
technologies, and continents
Founder and
President
IUCKA
India-United States
Cancer Knowledge Alliance
16
ASU contributes:
• 30+ years hands-on experience in diverse areas of
biomedical informatics
• Bioinformatics
• Clinical Research
• Health Informatics
• Experience in designing, implementing, and
executing a national informatics program
• Long Standing Global Health Program
ICTBioMed provides human and
computational capacity
IUCKA
India-United States
Cancer Knowledge Alliance
ICTBioMed Global Cloud
IUCKA
India-United States
Cancer Knowledge Alliance
Industry partners bring portfolios of
commercial-grade capabilities
• OncoPeer™
cloud community for oncology
• ARIA© Medical Oncology
• InSightive™ Analytics
- review, measure, evaluate
Cognitive Technology
IUCKA
India-United States
Cancer Knowledge Alliance
IUCKA fulfills its mission by
facilitating practical, value-added
projects that incrementally
create global capabilities
IUCKA
India-United States
Cancer Knowledge Alliance
IUCKA has tangible projects of
immediate importance to the Indian
Cancer Community
• Virtual Communities
• Access to International-Class Image
analysis tools
• “Smart” Electronic Clinical Management
• Common, shareable aggregated/integrated
molecular and clinical data
• Centered on understanding the mechanisms of
response and unique Indian response
IUCKA
India-United States
Cancer Knowledge Alliance
IUCKA is facilitating the
introduction of automated
feature analysis to extend
IUCKA
capacity
India-United States
Cancer Knowledge Alliance
Computer assisted evaluation
shows comparable performance
IUCKA
India-United States
Cancer Knowledge Alliance
Enhancing In Vivo Imaging capacity
• Enable use of State-of-the-Art
Image Analysis Capabilities
• E.g. automated segmentation
analysis
• Bring novel analytics to images
• Participants
• Tata Memorial Hospital
• Centre for Development of
Advanced Computing
• Massachusetts General
Hospital, Harvard
• Arizona State University
IUCKA
India-United States
Cancer Knowledge Alliance
Analytics brought to imaging data
using Docker payloads
Jayashree
Kalpathy-Cramer
MGH
1. Diffusion analysis
(single exponent, biexponent, stretched
exponent, NODDI)
2. DSC analysis
3. DCE analysis
4. Tumor segmentation
5. Multimodal
registration (single time
point)
6. Multimodal
registration (multiple
time points)
7. Voxel level analysis
(tissue classification)
image
resources
Amit Saxena
CDAC/BRAF
IUCKA
India-United States
Cancer Knowledge Alliance
IUCKA is facilitating the
generation of a “smart” clinical
information system that could be
used nationwide IUCKA
India-United States
Cancer Knowledge Alliance
“One Stop” Solution for Breast
Cancer Clinic Data Management
• Patient and Treatment Details database
• Proactive intelligent Database that learns
from each patient encounter
• Evidence-based Treatment guidance
• Results from Literature with a particular
treatment path
• Local patient experience
• National data
• Real time Statistical analysis for publications
• Platform for collecting national data
• Patient selection for trials/thesis enrollment
• Enrollment from time of screening
IUCKA
India-United States
28 Alliance
Cancer Knowledge
“One stop” Clinical Data
Management Platform Insights
• “Real time” effectiveness of interventions from
current data
• Assess differences in:
• Rural vs Urban rates of cancer?
• Age of onset?
• Triple-negative frequency?
• Validity of Gail-model risk assessment?
IUCKA
India-United States
Cancer Knowledge Alliance
IUCKA is participating in India-led
world-class translational research
activities
IUCKA
India-United States
Cancer Knowledge Alliance
Clinical research with Indian impact
11% improvement
in 5 year survival
IUCKA
India-United States
Cancer Knowledge Alliance
Understanding the molecular basis of
progesterone pre-treatment in breast
cancer
• Transcriptome analysis of progesterone pretreated breast cancer
• Understand molecular basis of treatment
• Assess the effects of hypoxia
• Participants
• Tata Memorial Hospital
• Advanced Center for Treatment, Research,
Education in Cancer
• National Cancer Institute Center for Biomedical
Informatics and information Technology
• Centre for Development of Advanced Computing
• Arizona State University
IUCKA
India-United States
Cancer Knowledge Alliance
Transcriptome analysis Use Case
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Data Samples generated at Tata Memorial Hospital Mumbai India
Sequencing done at NIBMG Kolkata India
Analyzed at
• BRAF C-DAC Pune India (using NCI pipeline)
• Advanced Center for Treatment, Research, Education in Cancer
• Arizona State University
IUCKA
India-United States
Cancer Knowledge Alliance
http://iucka.in
Indian National Cancer Grid
Srinagar
Jammu
IUCKA seeks to collaborate with
NCG members to better capture
the needs of the Indian Cancer
Community
IUCKA
Shimla
Chandigarh
Dehradun
New Delhi
Rohtak
Bareilly
Guwahati Naharlagun
Bikaner
Lucknow
Shillong
Jaipur
Varanasi
Kohima
Silchar
Gwalior
Jodhpur
Imphal
Allahabad Patna
Udaipur
Agartala
Satna
Ahmedabad Karamsad
Kolkata
Betul
Aizawl
Cuttack
Nagpur
Bhubaneshwar
Mumbai
Pune
India-United States
Hyderabad Vishakapatnam
Kolhapur
Cancer Knowledge Alliance
Kurnool
Tirupati
Bengaluru
Kancheepuram
Chennai
Vellore
Pondicherry
Thalassery
Coimbatore
Kochi
Thiruvananthapuram
IUCKA-NCG Collaborative Options
• Share needs of your organization
• Participate in developing projects
• Contribute capabilities that would enhance Alliance
• Share data with fellow NCG organizations
IUCKA
India-United States
Cancer Knowledge Alliance
Summary
• IUCKA is mobilizing stakeholder groups to work
together collaboratively to build knowledge so that all
cancer patients will benefit from uniformly high
standards of care, with continual science-based
progress that improves their clinical outcomes
• IUCKA leverages International Information Technology
capabilities to address challenges through practical
projects important to the Indian Cancer Community
• IUCKA is demonstrating its model through
International collaborative products
IUCKA
India-United States
Cancer Knowledge Alliance
Seeking Collaborators
and Partners
Come Join the Effort
[email protected]
[email protected]
IUCKA
India-United States
Cancer Knowledge Alliance