Transcript What is Active Surveillance?

Oncotype DX® Prostate Cancer Assay:
The Role of Genomics In Your Decision-Making
Is Active Surveillance Right For You?
Prostate Cancer Management:
A Guide for Patients and Caregivers
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Topics we will address today…
 Prostate Cancer Basics
 Understanding Your Treatment Options
 Active Surveillance
 Oncotype DX® Test Overview
 Additional Resources for Patients
 Next Steps
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Prostate cancer basics
What you and your loved ones need to know:
SOME
MOST
1 in 6
men will be
diagnosed with
prostate cancer
during their lifetime
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prostate cancers
are aggressive
and higher risk
prostate cancers
are not aggressive
and lower risk
(favorable pathology)
Low-risk prostate cancer is often over-treated
90%
OF MEN RECEIVE
IMMEDIATE TREATMENT
YET ONLY
3%
ARE AT RISK OF
PROGRESSION & DEATH
Grey bar represents 10% of patients who receive Active Surveillance
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A doctor’s perspective
“We desperately need the ability
to predict which patient has a
localized cancer that is going to
metastasize and cause suffering
and death, and which patient has
a cancer that is destined to stay
in the patient's prostate for the
remainder of his life.”
-Otis W. Brawley, MD
Chief Medical Officer
American Cancer Society
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Understanding your treatment options
IMMEDIATE
TREATMENT
OR
Potential Benefits
SURGERY
• Men may be cured if:
o Tumor has not spread
o All cancer is removed
o Radiation kills all
cancer
Potential Benefits
the
Potential Risks
•
•
•
•
•
ACTIVE
SURVEILLANCE*
Urinary incontinence
Erectile dysfunction
30-40% chance of recurrence
Use of a catheter for 1-2 weeks
Bowel control issues or rectal
bleeding (for radiation)
• Maintains window of cure
• Allows men with low-risk cancer to:
o Closely monitor their cancer
o Live out their entire lives without
surgery or radiation
o Avoid the side effects associated
with surgery and radiation
Potential Risks
• Slight risk that cancer may grow and
spread
• With a schedule of close monitoring it
should be caught before
it
spreads
RADIATION
*Includes biopsy; DRE (Digital Rectal Exam), PSA (Prostate-Specific
Antigen) testing, and MRI (Magnetic Resonance Imaging)
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What is Active Surveillance?
A program of closely monitoring and following your
prostate cancer avoiding surgery or radiation.
Periodic examinations may include*:
PSA Testing
Digital Rectal Exam (DRE)
Surveillance Biopsy
Magnetic Resonance Imaging(MRI)
If any changes are detected your doctor may recommend
additional treatment
* Timing and frequency of these examinations will be specified for you by your doctor
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Who is eligible for Active Surveillance?
Up to
HALF
of
men with low risk cancer
could be candidates for
Active Surveillance
Your doctor will assess your clinical risk
(an estimation of your cancer's aggressiveness)
to confidently recommend Active Surveillance
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10+ years of genomic experience
is a leading provider
of genomic cancer diagnostic tests:
Available TODAY
2004
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2010
2013
Principles of genomics
Genomics examines groups of genes and their
relationships in order to identify their combined
influence on your cancer’s behavior*
Oncotype DX® assay evaluates genes for:
Cell division
*At time of diagnosis
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Cell organization
Cell aggressiveness
The Oncotype DX® test provides
personalized information
Predicts the UNIQUE BIOLOGY of your tumor
based on biopsy tissue
Examines the expression of a panel of GENES
associated with prostate cancer pathology and
progression, a science known as “genomics”
Provides a more specific and PRECISE
risk assessment than clinical risk alone
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Quick facts about Oncotype DX®
Prostate Cancer Assay
GPS
Who is the test
for?
What is the
Genomic Prostate
Score (GPS)?
Patients with
very low to
low-intermediate risk
disease
Your Oncotype DX® results are
reported as a GPS, that when
combined with other clinical
factors, can further clarify your
risk
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What is
Favorable
Pathology?
Confirmation that the
tumor is low risk and
fully confined to the
prostate
Oncotype DX® along your prostate cancer journey
SCREENING
DIAGNOSIS
PSA
DRE
Biopsy
Gleason
Stage
TREATMENT
DECISION
Active Surveillance
OR
Immediate Treatment
It is a genomic test that gives you and
your doctor confidence to choose
the best management plan for your cancer
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GPS helps provide a precise risk assessment
GPS
VERY LOW
0
More
favorable
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LOW
INTERMEDIATE
Likelihood of favorable
pathology
100
Less
favorable
Know your score. Know your risk.
The LOWER
YOUR GPS,
The HIGHER
YOUR GPS,
the more favorable
your tumor biology,
and the more likely
you can safely
consider Active
Surveillance
the less favorable your
tumor biology, and the
more likely that you
should consider
Immediate Treatment
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A patient’s perspective
Choose with confidence
“I was determined to educate
myself about all of my options,
and thanks to Oncotype DX®, I
confidently chose Active
Surveillance based on my
GPS result.”
-Dan W.
Oncotype DX®
Prostate Cancer
Patient Ambassador
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Financial assistance is available
The Genomic Access Program (GAP) takes every
possible step to ensure that testing is:
Affordable
Available
• If your potential
out-of- • You are eligible
pocket costs exceed
regardless of your
$100, GAP will contact
insurance status
you by phone to help you
understand these costs
• Genomic Health
contracts directly with
most insurers or thirdparty payers to secure
the best coverage
possible
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Accessible
• GAP contacts your
insurance company to
determine whether you
are covered for the
Oncotype DX® test
• You can prequalify for
patient assistance on the
spot simply by providing
some basic financial
information
A patient’s perspective
Choose with confidence
“Gain as much
information as possible
to make the best
decision for yourself.”
-Dan W.
Oncotype DX®
Prostate Cancer
Patient Ambassador
”
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Your Prostate Your Decision
www.YourProstateYourDecision.com
Your Prostate Your Decision
is a national campaign to
educate patients and their
loved ones that every man is
different and every cancer is
unique, and a genomic test
can clarify the aggressiveness
of one’s disease prior to
invasive treatment.
Watch a public service announcement
Featuring baseball Hall-of-Famer &
prostate cancer survivor Joe Torre
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Joe Torre, Prostate Cancer Survivor,
4-time World Champion and Baseball Hall-of-Famer
Resources for your prostate cancer journey
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Next steps
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1
LEARN MORE
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CONSIDER YOUR OPTIONS
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ASK YOUR DOCTOR
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CALL
about your prostate cancer
you have time to choose with confidence
about the Oncotype DX® Prostate Cancer Assay
+1-855-6PROSTATE
Thank You
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