Transcript This type of genetic disorder requires both parents to *donate* a

This type of genetic disorder
requires both parents to “donate” a
defective gene
Autosomal recessive (2 little letters:
aa, bb, ff) found on 1 of the first 22
chromosomes
What is it called when an offspring is
heterozygous for a recessive genetic
disorder?
A carrier (Dd, Hh, Aa)
There are no carriers for these fatal
diseases. If you have one copy of this
gene then you HAVE the disease
Autosomal Dominant
Give an example of 1 autosomal
dominant disease
1- Huntington’s Chorea
- like Parkinson’s
where physical and mental abilities
deteriorate
2 - Marfan’s syndrome – Lincoln was
thought to have this (very tall – usually
die of heart problems)
the most common genetic disorder
among black people. Red blood cells
are abnormally shaped
Sickle cell anemia
This genetic disorder is seen in all
races of people and animals where
pigment (color) is missing
Albinism
X-linked genetic disorders are carried
on the X chromosome
Sex linked genetic disorder
With sex linked genetic disorders, why
is it that boys are mostly affected?
Girls have XX so if 1 X is damaged, the
other chromosome dominates
BUT
boys have XY so if the X is damaged,
the Y cannot compensate
Who is the carrier for sex linked
disorders?
Women are carriers of the disease –
They DO NOT have it, but with each
pregnancy they have a 50-50 chance
of passing it on to their sons – those
sons are NOT carriers
Give 1 example of a sex linked disorder
hemophilia (The Royal Disease of
Europe), color blindness, Duchenne’s
Muscular Dystrophy and
Adrenoleukodystrophy (ALD)
the most commonly inherited genetic
disorder among Caucasian people. It
produces a great deal of phlegm build
up.
Cystic fibrosis
The universal blood donor
Type O
Aside from taking blood, where else
can your blood type be found?
Bodily fluids such as saliva, semen and
vaginal secretions
What are the 4 different blood types?
A = IA IA or IAi
B = IBIB or IBi
AB = IAIB
O = ii
The universal blood recipient
Type AB
These genetic disorders are most
common among people of Eastern
European origin – both parents must
be carriers
Jewish genetic disorders such as:
Tay-Sachs, Niemann-Pick, Canavan’s
Disorder, Bloom’s Disease, Familial
Dysautonomia and Fanconi Anemia
A diagram that shows the occurrence
or appearance of a particular gene or
organism from 1 generation to the
next
Pedigree chart
Name common pedigree symbols
Interpret the following pedigree chart:
1 – autosomal dominant disease
because the chart shows no carriers
2- in generation II, three out of the 5
siblings have the disease
3 – out of the generation II sibling that
got married (2) who have the disease,
they passed the disease to 50% of
their offspring
Interpret this chart:
Sex linked trait (for color blindness)
because most of the females are
carriers and most of the males get the
disorder
Cross an male with type AB blood with
a female who is heterozygous type A
Female: IAi
Male: IAIB
Result:
2 type A offspring: IAIA, Iai
1 type AB: IAIB
1 type B: IBi