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From: Differentially Expressed Genes in MHC-Compatible Rat Strains That Are Susceptible or Resistant to Experimental
Autoimmune Uveitis
Invest. Ophthalmol. Vis. Sci.. 2008;49(5):1957-1970. doi:10.1167/iovs.07-1295
Figure Legend:
Hierarchical clustering of gene expression levels in LN cells from LEW and F344 rats from induction to resolution of
EAU. RNA was isolated from the draining LNs of individual naïve or immunized LEW or F344 rats (n = 4 per time point).
For analysis, RNA samples were pooled in equal amounts within each group, and the cDNAs generated were used for
microarray analysis. Samples were analyzed on three different microarray membranes, each containing a duplicate set
of genes. The averages of the three z-normalized data sets per time point per strain were used for hierarchical
clustering. Different patterns of gene expression were evident in susceptible LEW and resistant F344 LN cells during the
timeofcourse
of the
disease development.
Red: genes
were upregulated
the LEW strain
in comparison
F344
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strain; green: downregulated genes. Genes showing major differences at days 0 and 3 are magnified. Blue outlines