Transcript and genomics - FISH-BOL

Fish Genomics in Canada
Christian Burks
[email protected]
www.OntarioGenomics.ca
Fish Genomics in Canada
• Ontario Genomics Institute
• Fish Genomics
Fish Barcode Workshop, 7 June ‘05, page 2
From Central Dogma to Discovery Platforms
genes
proteins
holistic, high-throughput & systematic approaches to building resources
genomics
proteomics
Fish Barcode Workshop, 7 June ‘05, page 3
Ontario Genomics Institute (OGI)
Building a globally-competitive life sciences industry in Ontario
• Fund top tier science & technology
• Fund best organized projects
• Facilitate & precipitate commercialization
• Focus on societal outcomes
• 50% co-funding requirement (international collaborations count)
Fish Barcode Workshop, 7 June ‘05, page 4
OGI R&D Project Portfolio
• $320M portfolio of 24 projects to date led by Ontario scientists
• $3M - $30M per program ($10M average)
• human health, tech development, agriculture, forestry & environment
• examine associated impact: ethics, environment, economic, legal & social
• 2 “platform” projects: proteomics (PTCF) and genomics (GRC)
Fish Barcode Workshop, 7 June ‘05, page 5
International Programs
Structural Genomics Consortium
• Led by Aled Edwards @ University of Toronto
• Detailed three-dimensional structure of 350 proteins (starting point for drug discovery)
• $115M
• ICI: work being done in and funded by Canada, United Kingdom & Sweden
Segmented DNA Duplications
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Ontario work led by Steve Scherer @ Hospital for Sick Children
Duplicated DNA in neurodevelopmental-diseases and evolution
$6M
work being done in and funded by Canada & Spain (Genoma España)
International Regulome Consortium (in planning & development)
• Led by Michael Rudnicki @ Ottawa Health Research Institute
• map the mechanisms and networks that control the genes that comprise the genome
• $$$ to be determined …. ultimately, $50M - $100M; program development funds from MEDT
• potential ICI: Canada, Australia, France, Germany, Italy, Netherlands, Singapore, UK & USA
Fish Barcode Workshop, 7 June ‘05, page 6
Fish Genomics in Canada
• Ontario Genomics Institute
• Fish Genomics
Fish Barcode Workshop, 7 June ‘05, page 7
Atlantic Salmon Genomics
Leads:
Willie Davidson (Simon Fraser U.) &
Ben Koop (U. Victoria)
Collaboration:
Bjorn Hoyheim (Norwegian School of Veterinary Science)
Sharing BAC libraries, ESTs, QTL markers, etc.
Funding:
$6M (Genome Canada & others) & $6M (Norway)
Focus:
Integrate genetic and physical maps
Identify genes ( > 16,000)
 linked to disease, stress, growth, and development
 use variation for identifying conservation units
Characterize gene regions relevant to aquaculture
 immune system genes
 stress and disease
 sex determination
Fish Barcode Workshop, 7 June ‘05, page 8
Aquaculture Disease Management
Lead:
Laura Brown (NRC Institute for Marine Biosciences)
Consortium:
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Funding:
$9M (NRC’s Genomics and Health Initiative & others)
Focus:
genomics, proteomics & metabolomics
 to produce vaccines & vaccine delivery systems
for Aeromonas salmonicida
 to understand the effects of husbandry stressors
on vaccine efficacy
NRC Institute for Marine Biosciences, Halifax
NRC Institute for Biological Sciences, Ottawa
Dalhousie University, Department of Microbiology
Fisheries and Oceans Canada
Fish Barcode Workshop, 7 June ‘05, page 9
Flatfish Genomics
Leads:
Susan Douglas (NRC IMB, Canada) &
Joan Cerda Luque (IRTA, Spain)
Consortium:
Genome Canada (NRC IMB, Dep’t of Fisheries and
Oceans, Scotian Halibut Ltd.)
Genoma España (Nine academic & government
organizations, Oryzon Genomics)
Funding:
$5M ($2M from Genome Canada)
Focus:
Large-scale genomics and proteomics approaches
to enhance the commercial culture of Atlantic
Halibut and Senegal Sole.
 gene sequencing
 expression arrays
 genetic linkage maps
Fish Barcode Workshop, 7 June ‘05, page 10
Zebrafish Functional Genomics
Lead:
Marc Ekker (CAREG, U. Ottawa)
Funding:
CIHR, NSERC
Focus:
environment - impact of environmental stressors on
genome expressivity
 identification of novel biomarkers
human health - screens for novel mutations
 model Parkinson’s disease, heart arrhythmia &
sexual differentiation
 reporter transgenic zebrafish for functional
assays
Fish Barcode Workshop, 7 June ‘05, page 11
Ontario Genomics Institute
Christian Burks
[email protected]
www.OntarioGenomics.ca