Transcript NCBI: what is new?

NCBI: something old, something new
What is NCBI?
On November 4, 1988 that President Ronald
Reagan signed the Health Omnibus Extension
Act to create The National Center for
Biotechnology Information as part of National
Library of Medicine at NIH.
• Create automated systems for knowledge
about molecular biology, biochemistry, and
genetics.
• Perform research into advanced methods of
analyzing and interpreting molecular
biology data.
• Enable biotechnology researchers and
medical care personnel to use the systems
and methods developed.
The National Center for
Biotechnology Information (NCBI)
Bethesda,MD
Part of
National Library of Medicine (NLM) at
National Institutes of Health (NIH)
NCBI: down on the farm
• Genome assembly and
annotation
• Pre-computed relationships
for:
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Protein clusters
“Nearby” nucleic acid
EST unigene clusters
Putative homologous genes
Conserved protein domains
SNPs
Reciprocal links
NCBI Daily Users
3,000,000
2,500,000
Web page views: 26 million per day
Web users: 2.7 million per day
2,000,000
Data downloaded: 23 TB per day
Peak web hits: 7,000 per second
1,500,000
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NCBI: Integrated platform for data
analysis and visualization
Primary Data sets: BioProject, BioSample,
Genome, Assembly, Annotation
Curated data sets: Refseq genomes, Gene,
Protein Clusters, Pathogenic Factors, Targeted
Loci
Entrez search and retrieval system
Analysis Tools: Annotation pipeline, genome
alignments, protein clustering, multiple
alignments, (assembly, SNP)
Validation Tools: assembly and annotation
quality assesment
Visualization Tools: genomeMap, distance
tree, proteinMap, Genome Comparison
How to navigate through NCBI
resources
Text search in Entrez
Search in MapViewer
All databases
Specialized databases
Use limits page
Sequence search
BLAST
Genome BLAST
Splign/ProSplign
Marker/gene name
Accession #
Organism name
Pre-computed similarities
Blink
CDD
TaxPlot
Use Genome specific resources
Getting Started: NCBI Home Page
Search resources by
name
http://www.ncbi.nlm.nih.gov
Search All
Databases in
Entrez
Learn more:
Newsletter
Education
mailing lists
NCBI Resources by name
How to: NCBI help pages
The NCBI Handbook
Keeping up with what’s new
NCBI News on Bookshelf
www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi
Genetic Testing Registry (GTR)
BLAST
Entrez Assembly
Entrez Genome redesign
Microbial Genome Resources
NCBI on Facebook and Twitter
David Lipman on GenBank 25th
Anniversary