Transcript HH

Answer the following questions with your
elbow partner:
 What physical traits did you inherit and from
whom?
 What traits can be inherited?
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Definition – diagram of family relationships that
use symbols to represent people and lines to
represent genetic relationships. (genotypes &
phenotypes)
Example :
Sentence – Write a sentence using the word
pedigree on your graphic organizer.
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Definition – a genotype is the genetic make
up of a cell, or the alleles
Example – AA (homozygous dominant) Aa
(heterozygous) aa (homozygous recessive)
Non-Example – Freckles
Sentence
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Definition – is an organisms observable traits,
or physical characteristics.
Example – Blue eyes, Freckles, Brown Hair
Non-Example – Aa, AA, aa
Sentence
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Read pages 396-397 out of your textbook.
Answer the following questions with your
elbow partner.
◦ What are pedigree charts?
◦ What are the symbols and what do they mean?
◦ In the sample pedigree pictured on page 397, what
are the genotypes of both parents on the left in the
second generation?
◦ How do you know?
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Males & females are equally likely to have the
trait
Traits DO NOT skip generation
Males can transmit to both sons and
daughters
The trait is present whenever the
corresponding gene is present
Parent 1 = Huntington’s Disease
Parent 2 = Normal
H
h
h
Hh (Huntington’s)
hh
h
Hh (Huntington’s)
hh
Parent 1 = Normal
Parent 2 = Normal
h
h
h
hh
hh
h
hh
hh
Parent 1 = Huntington’s Disease
Parent 2 = Huntington’s Disease
H
h
H
Hh (Huntington’s)
Hh (Huntington’s)
h
Hh (Huntington’s)
Hh (Huntington’s)
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Partner 1, tell Partner 2 some of the
characteristics of an Autosomal Dominant
disorder.
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Males & females are equally likely to have the
trait
Trait often skips generations
Only homozygous individuals have the trait
Parents who have children with the trait must
be heterozygous
If a parent has the trait, their offspring who
do not have it are heterozygous carriers for
the trait
Parent 1 = Carrier
Parent 2 = Normal
F
f
F
FF
Ff (Carrier)
F
FF
Ff (Carrier)
Parent 1 = Carrier
Parent 2 = Carrier
F
f
F
FF
Ff (Carrier)
f
Ff (Carrier)
ff (Cystic Fibrosis)
Parent 1 = Cystic
Fibrosis
Parent 2 = Carrier
f
f
F
Ff (Carrier)
Ff (Carrier)
f
ff (Cystic Fibrosis)
ff (Cystic Fibrosis)
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Partner 2, tell Partner 1 what some
characteristics of Autosomal Recessive
disorders are.
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Trait is coded for on the X chromosome
All sons of a male who has the trait will also
have the trait
A father can not pass the trait on to their
daughter
A female who has the trait may or may not
pass the gene for that trait to her son or
daughter
Mom = Carrier
Dad = Normal
X0
X
X
X0X (CL
Syndrome)
XX
Y
X0Y (CL
Syndrome)
XY
Mom = Normal
Dad = Normal
X
X
X
XX
XX
Y
XY
XY
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Partner 1, tell Partner 2 explain some of the
characteristics of an X-link Dominant
disorder.
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Trait is coded for on the X chromosome
Trait more common in males than females
If a male has the trait, all of his daughters will be
heterozygous carriers
Sons of female carriers have a 50% chance of
having the trait
Males can not pass the trait to their sons
A male inherits the trait from his mother who is a
carrier
Daughters of female carriers have a 50% chance
of being a carrier
Mom=Carrier
Dad = Normal
X0
X
X
X0X (Carrier)
XX
Y
X0Y (DMD)
XY
Mom = Normal
Dad = Normal
X
X
X
XX
XX
Y
XY
XY
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Partner 2, tell Partner 1 some characteristics
of an X-link Recessive disorder.
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With a partner, determine whether the
pedigree is an example of a AR, AD, XR, or
XD.
Write the answers in on your graphic
organizer.
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Does alkaptonuria
appear to be caused by a
dominant or recessive
allele?
What are the genotypes
of the following
individuals?
◦
◦
◦
◦
◦
George
Carla
Tom
Arlene
Michael
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Work through question 18 with your elbow
partner. Be prepared to share your answers
with the class.
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Bob = Aa
Barb = aa
Charlie = Aa
Ethan = aa
Candice = Aa
Isabelle = aa
Candice =
Huntington’s
Parker = Normal
A
a
a
Aa
aa
a
Aa
aa
50% Chance
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Answer the questions for question 19
individually. Be prepared to share out to the
class.
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Edward VII = XY
Alice = XhX
Queen Victoria = XhX
Leopold = XhY
Beatrice = XhX
Henry of Prussia = XY
Leopold =
Hemophilia
Wife = Non-Carrier
Xh
Y
X
XhX
XY
X
XhX
XY
0% Chance of
Hemophilia
100% Chance o
being a carrier
Working with a partner, read through the case
study of the Grouch family.
 Answer 20 a and 20 b with your partner.
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Hemoglobin is the ironcontaining oxygentransport protein in red
blood cells.
Methemoglobin is a form
of a hemoglobin that
can’t bind oxygen. When
excess methemoglobin is
present, the blood
becomes abnormally
dark and can cause some
skin discoloration.
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Read paragraphs 1-20. Stop and write a
short summary.
Read paragraphs 21-40. Stop and write a
short summary.
Read paragraphs 41-58. Stop and write a
short summary.
Answer the following questions about your reading
with your partner on your graphic organizer:
 What is the name of the disorder described in the
article?
 Describe the group of people effected by this
disorder.
 Is the disorder autosomal or x-linked?
 Is the disorder recessive or dominant?
 Where did this population reside?
 Describe the symptoms of the disorder?
 How was this disorder inherited?
 Why was the disorder isolated to this population?
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Draw a pedigree chart of your family
including yourself, your parents and siblings,
your parents.
◦ Identify and color the symbols accordingly for one
of the following traits:
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Right or left handed
Freckles
Free/attached earlobes
Widows peak
Tongue roller/non-roller